diff --git a/CHANGELOG.md b/CHANGELOG.md
index ec1bf1e8..4ce8c73a 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,5 +1,12 @@
 # Changelog
 
+## [1.6.1](https://github.com/googleapis/java-iam/compare/v1.6.0...v1.6.1) (2022-09-21)
+
+
+### Dependencies
+
+* Update dependency com.google.protobuf:protobuf-java to v3.21.6 ([#425](https://github.com/googleapis/java-iam/issues/425)) ([61cbdf4](https://github.com/googleapis/java-iam/commit/61cbdf4c4ad3c559670cc39c864dfd03f8303667))
+
 ## [1.6.0](https://github.com/googleapis/java-iam/compare/v1.5.2...v1.6.0) (2022-09-20)
 
 
diff --git a/google-iam-policy/pom.xml b/google-iam-policy/pom.xml
index e7bb9c3e..58b22ae7 100644
--- a/google-iam-policy/pom.xml
+++ b/google-iam-policy/pom.xml
@@ -3,7 +3,7 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.cloud</groupId>
   <artifactId>google-iam-policy</artifactId>
-  <version>1.6.0</version><!-- {x-version-update:google-iam-policy:current} -->
+  <version>1.6.1</version><!-- {x-version-update:google-iam-policy:current} -->
   <packaging>jar</packaging>
   <name>Google IAM Policy</name>
   <url>https://github.com/googleapis/java-eventarc</url>
@@ -11,7 +11,7 @@
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-iam-parent</artifactId>
-    <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v1:current} -->
+    <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v1:current} -->
   </parent>
   <properties>
     <site.installationModule>google-iam-policy</site.installationModule>
diff --git a/grpc-google-iam-v1/pom.xml b/grpc-google-iam-v1/pom.xml
index 6e2d58a9..4f94210d 100644
--- a/grpc-google-iam-v1/pom.xml
+++ b/grpc-google-iam-v1/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>grpc-google-iam-v1</artifactId>
-  <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v1:current} -->
+  <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v1:current} -->
   <name>grpc-google-iam-v1</name>
   <description>GRPC library for grpc-google-iam-v1</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-iam-parent</artifactId>
-    <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v1:current} -->
+    <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v1:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/grpc-google-iam-v2/pom.xml b/grpc-google-iam-v2/pom.xml
index 77dbe5bb..fe517252 100644
--- a/grpc-google-iam-v2/pom.xml
+++ b/grpc-google-iam-v2/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>grpc-google-iam-v2</artifactId>
-  <version>1.6.0</version><!-- {x-version-update:grpc-google-iam-v2:current} -->
+  <version>1.6.1</version><!-- {x-version-update:grpc-google-iam-v2:current} -->
   <name>grpc-google-iam-v2</name>
   <description>GRPC library for proto-google-iam-v2</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-iam-parent</artifactId>
-    <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v1:current} -->
+    <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v1:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/grpc-google-iam-v2beta/pom.xml b/grpc-google-iam-v2beta/pom.xml
index 2f0729e7..f9031c53 100644
--- a/grpc-google-iam-v2beta/pom.xml
+++ b/grpc-google-iam-v2beta/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>grpc-google-iam-v2beta</artifactId>
-  <version>1.6.0</version><!-- {x-version-update:grpc-google-iam-v2beta:current} -->
+  <version>1.6.1</version><!-- {x-version-update:grpc-google-iam-v2beta:current} -->
   <name>grpc-google-iam-v2beta</name>
   <description>GRPC library for proto-google-iam-v1</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-iam-parent</artifactId>
-    <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v1:current} -->
+    <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v1:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/pom.xml b/pom.xml
index 0ce6d7c9..bd1216d2 100644
--- a/pom.xml
+++ b/pom.xml
@@ -4,7 +4,7 @@
   <groupId>com.google.cloud</groupId>
   <artifactId>google-iam-parent</artifactId>
   <packaging>pom</packaging>
-  <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v1:current} -->
+  <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v1:current} -->
   <name>Google IAM Parent</name>
   <url>https://github.com/googleapis/java-iam</url>
   <description>
@@ -77,37 +77,37 @@
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-iam-v2</artifactId>
-        <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v2:current} -->
+        <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v2:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>grpc-google-iam-v2</artifactId>
-        <version>1.6.0</version><!-- {x-version-update:grpc-google-iam-v2:current} -->
+        <version>1.6.1</version><!-- {x-version-update:grpc-google-iam-v2:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.cloud</groupId>
         <artifactId>google-iam-policy</artifactId>
-        <version>1.6.0</version><!-- {x-version-update:google-iam-policy:current} -->
+        <version>1.6.1</version><!-- {x-version-update:google-iam-policy:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-iam-v2beta</artifactId>
-        <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v2beta:current} -->
+        <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v2beta:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>grpc-google-iam-v1</artifactId>
-        <version>1.6.0</version><!-- {x-version-update:grpc-google-iam-v1:current} -->
+        <version>1.6.1</version><!-- {x-version-update:grpc-google-iam-v1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>grpc-google-iam-v2beta</artifactId>
-        <version>1.6.0</version><!-- {x-version-update:grpc-google-iam-v2beta:current} -->
+        <version>1.6.1</version><!-- {x-version-update:grpc-google-iam-v2beta:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-iam-v1</artifactId>
-        <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v1:current} -->
+        <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v1:current} -->
       </dependency>
 
       <dependency>
diff --git a/proto-google-iam-v1/build.gradle b/proto-google-iam-v1/build.gradle
index be64827e..4faf2f70 100644
--- a/proto-google-iam-v1/build.gradle
+++ b/proto-google-iam-v1/build.gradle
@@ -18,7 +18,7 @@ repositories {
 }
 
 dependencies {
-  compile 'com.google.protobuf:protobuf-java:3.21.5'
+  compile 'com.google.protobuf:protobuf-java:3.21.6'
   compile 'com.google.api:api-common:2.2.1'
   compile project(':proto-google-common-protos')
 }
diff --git a/proto-google-iam-v1/pom.xml b/proto-google-iam-v1/pom.xml
index 001d49a3..2c05a7fa 100644
--- a/proto-google-iam-v1/pom.xml
+++ b/proto-google-iam-v1/pom.xml
@@ -3,13 +3,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>proto-google-iam-v1</artifactId>
-  <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v1:current} -->
+  <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v1:current} -->
   <name>proto-google-iam-v1</name>
   <description>PROTO library for proto-google-iam-v1</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-iam-parent</artifactId>
-    <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v1:current} -->
+    <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v1:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/proto-google-iam-v2/pom.xml b/proto-google-iam-v2/pom.xml
index fe8d2030..f461670a 100644
--- a/proto-google-iam-v2/pom.xml
+++ b/proto-google-iam-v2/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>proto-google-iam-v2</artifactId>
-  <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v2:current} -->
+  <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v2:current} -->
   <name>proto-google-iam-v2</name>
   <description>Proto library for proto-google-iam-v1</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-iam-parent</artifactId>
-    <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v1:current} -->
+    <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v1:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/proto-google-iam-v2beta/pom.xml b/proto-google-iam-v2beta/pom.xml
index c6d63a0a..2954a33e 100644
--- a/proto-google-iam-v2beta/pom.xml
+++ b/proto-google-iam-v2beta/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>proto-google-iam-v2beta</artifactId>
-  <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v2beta:current} -->
+  <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v2beta:current} -->
   <name>proto-google-iam-v2beta</name>
   <description>Proto library for proto-google-iam-v1</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-iam-parent</artifactId>
-    <version>1.6.0</version><!-- {x-version-update:proto-google-iam-v1:current} -->
+    <version>1.6.1</version><!-- {x-version-update:proto-google-iam-v1:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/versions.txt b/versions.txt
index 5d8698a5..e1f86383 100644
--- a/versions.txt
+++ b/versions.txt
@@ -1,10 +1,10 @@
 # Format:
 # module:released-version:current-version
 
-proto-google-iam-v1:1.6.0:1.6.0
-grpc-google-iam-v1:1.6.0:1.6.0
-proto-google-iam-v2beta:1.6.0:1.6.0
-grpc-google-iam-v2beta:1.6.0:1.6.0
-google-iam-policy:1.6.0:1.6.0
-proto-google-iam-v2:1.6.0:1.6.0
-grpc-google-iam-v2:1.6.0:1.6.0
+proto-google-iam-v1:1.6.1:1.6.1
+grpc-google-iam-v1:1.6.1:1.6.1
+proto-google-iam-v2beta:1.6.1:1.6.1
+grpc-google-iam-v2beta:1.6.1:1.6.1
+google-iam-policy:1.6.1:1.6.1
+proto-google-iam-v2:1.6.1:1.6.1
+grpc-google-iam-v2:1.6.1:1.6.1