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Ventures in AI: Discover 7 trends shaping startup AI according to leading VCs

April 28, 2025
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Darren Mowry

Vice President, Worldwide Startups Organization, Google Cloud

Our new guide for startups has the latest trends that more than a dozen top VCs see driving the future of, and with, AI.

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Building a successful startup demands more than just a great product, a passionate team, and a proven market. It’s as much about staying ahead of the curve, understanding the forces shaping the venture funding landscape, and positioning your startup for sustainable growth.

At Google Cloud, we want to provide startups not only with the technical innovations that can drive their business but also the connections and insights to the world of venture capital. This unique combination can help founders navigate the complexities of the funding world and build truly impactful companies.

Take our new report, The AI Road Ahead: 7 Game-Changing VC Trends.

This comprehensive guide distills specific insights on the future of generative AI and its intersections in the startup world from the Google Cloud VC AMA Series. For years, we’ve been gathering leading venture capital investors to share the latest strategies and perspectives on building, fundraising, and growing a venture-backable startup. To meet the AI moment, we wanted to capture their views on where the technology is taking their portfolio companies — and companies across industries and across the world.

After all, gen AI is transforming the startup landscape both as a tool and as a foundational technology that powers innovation. As a horizontal technology, AI impacts every vertical we discuss in the report and enables founders to innovate faster and smarter. At Google Cloud, we're equipping startups with cutting-edge AI infrastructure like Vertex AI and our powerful multimodal model, Gemini, to help them bring their AI-powered visions to life.

So how exactly are technologies like these having an impact? You can get the highlights of all seven trends below, or download the report to go even deeper.

Trend #1: Powering the future of work

Venture capitalists are increasingly focused on AI-driven solutions that enhance efficiency, productivity, and decision-making across organizations.

Patrick Chase, partner at Redpoint Ventures, notes, “In enterprise, generative AI and large language models (LLMs) are still in their early stages of adoption.” Similarly, Monica Saggioro, general partner at MAYA Capital, states, “AI is here to stay. It’s no longer a vertical.”

Jessica Leão, partner at Decibel, emphasizes that AI allows humans to focus on “strategic thinking and next-step analysis” instead of mundane tasks. The shift towards autonomous AI agents that work alongside humans is gaining momentum, making this a pivotal area for investment.

VCs want to see AI that is integrated into core business functions, automating repetitive tasks to improve operational efficiencies and enhancing decision-making among knowledge workers.

Trend #2: Transforming traditional industries

AI is now reshaping industries that previously may have been considered resistant to technological disruption, including manufacturing, agriculture, legal, and education.

Anna Barber, investing partner at M13, points to opportunities in the legal and accounting fields, where AI can deliver personalized services directly. Similarly, Susli Lie, partner at Monk's Hill Ventures, emphasizes AI’s role in enhancing crop yields and optimizing resource utilization in agriculture.

Startups that identify untapped opportunities in sectors traditionally averse to breakthrough tech and find ways to address industry-specific challenges with deeply specialized AI have a high ceiling for success.

Trend #3: Redefining global finance

Fintech is revolutionizing financial services by making them more accessible, convenient, and personalized. Angela Strange, general partner at a16z, famously stated, “Every company is going to be a fintech company.” This prediction is materializing as companies integrate financial services into their ecosystems.

Lie of Monk’s Hill Ventures sees “fintech 2.0” driving a new era of specialized financial solutions, particularly in open banking, insurance tech, and real-time settlements.

Specialized solutions focused on subsectors like blockchain and embedded finance and methods to penetrate previously underserved markets are increasingly attractive to VCs.

Trend #4: Enhancing patient care and healthcare outcomes

Healthcare stands to gain much from AI, especially if it can “put patients back at the center” says Gabby Contro, partner at Crosslink, who sees streamlining clinical workflows and reducing administrative burdens as major opportunities.

M13’s Barber points to companies which use AI to detect chronic diseases earlier, improving patient outcomes and lowering healthcare costs.

Startups that find ways to uncover actionable insights, accelerate drug discovery, and optimize clinical workflows will play a pivotal role in healthcare’s seismic transformation.

Trend #5: Protecting data and privacy in a digital world

Cyber threats are growing more sophisticated and regulation — as well as traditional security techniques and technologies — are struggling to keep up. Alex Szapiro, managing partner at SoftBank Latin America Fund, emphasizes that cybersecurity solutions must evolve faster than regulations.

Fresh ideas and creative solutions are plentiful in the startup space, and will be vital to the health of the world’s digital assets and systems. Founders that wield AI to further automate threat detection, surpass compliance requirements, and make zero-trust frameworks more accessible will attract VCs focused in this growing area.

Trend #6: Building a greener future

The climate crisis is accelerating investment in sustainable startups. MAYA Capital’s Saggioro, spotlights NotCo, a plant-based food company leveraging AI to optimize plant-based ingredient combinations.

Lie of Monk’s Hill Ventures highlights Southeast Asia’s emerging green tech sector, particularly in hydro-related renewable energy and sustainable supply chains.

The world needs integrated and scalable solutions that can drive sustainability in food, energy, transportation, and other high-impact industries. Keeping AI tools lean and affordable through specialized, climate-friendly innovation will help more companies in these industries succeed well into the future.

Trend #7: A global investment shift beyond Silicon Valley

Startups are no longer confined to Silicon Valley. Vibrant innovation hubs are emerging worldwide, creating a truly borderless ecosystem of opportunity.

Mish Mashkautsan, general partner at LocalGlobe, emphasizes the importance of global reach. Softbank’s Szapiro points to Brazil’s advancements in fintech, fraud control, and payments as examples of regional innovation with global relevance.

This means startups have an ever-growing ecosystem of new hubs and global talent through which they can solve regional problems with diverse teams.

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Opening image created with Imagen 3 in Vertex AI Studio using the prompt: This is intended as an illustration for a smart weekly business and technology publication. The article is about seven trends for AI driving startups. Can you create an isometric view of a city, and at its center is a stack of seven block-shaped buildings coming together to form an interconnected pyramid-like structure? Don't make the image look too sci-fi or futuristic, just conventional contemporary buildings with this big pyramid structure in the center of the frame. It should look peaceful and inspiring, not ominous. // Can you make it look like the central structure's pieces are more in motion, clicking together, and maybe glowing a bit, so they stand out more from the whole? Maybe make them slightly different colors, too, so they look more individual but coming together.

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