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Accesos Vasculares por Ultrasonografia
Accesos Vasculares por Ultrasonografia
Accesos Vasculares por Ultrasonografia
Accesos Vasculares por Ultrasonografia
Parienti JJ. Et al .N Engl J Med 2015;373:1220-9.
15%
Accesos Vasculares por Ultrasonografia
Accesos Vasculares por Ultrasonografia
CHEST 2016; 149(1):166-179
Riesgos y ventajas asociadas a la inserción de
línea arterial por el método de palpación vs US
20 estudios
N = 1990
2003 al 2015
RR: 0.68
US Disminuye el numero de intentos
CHEST 2016; 149(1):166-179
CHEST 2016; 149(1):166-179
CHEST 2016; 149(1):166-179
7 Estudios
289 pacientes
US vs método tradicional
Aumenta
probabilid
ad de éxito
107/136 US
vs 84/136 a
ciegas
OR 2.42
Intensive Care Med (2012) 38:1105–111
La
Lamperti M et al
Intensive Care Med (2012) 38:1105–111
• Debe ser usado rutinariamente (A)
• PICC se debe colocar con eco (A)
• Si se anticipa una línea arterial difícil, se debe considerar US (B)
• La línea arterial con eco mejora el éxito de la anulación (A)
• Si hay sospecha de neumotórax post punción, realizar US de
pulmón (B)
• Es costo efectivo (A)
La
Lamperti M et al
Critical Care Medicine.1996; 24(12):2053-2058
8 estudios
247Y 255
US vs técnica con referencia anatómica
-Yugular
-Subclavio
• Intentos fallidos
• Complicaciones
Accesos Vasculares por Ultrasonografia
REDUCE EL RIESGO DE
INTENTOS FALLIDOS
DISMINUCION DE LAS
COMPLICACIONES
9 seg mas rápido la US
18 estudios
1646 pacientes
US vs técnica con referencia anatómica
-Yugular
-Subclavio
-Femoral
Hind D, Calvert N, McWilliams R, Davidson A, Paisley S, Beverley C, Thomas S (2003) Ultrasonic
locating devices for central venous cannulation: meta-analysis. BMJ 327:361
REDUCE EL RIESGO DE
INTENTOS FALLIDOS EN
86%
DISMINUCION EN 57% DE
LAS COMPLICACIONES
DISMINUCION EN EL
NUMERO DE INTENTOS
41%
Hind D, Calvert N, McWilliams R, Davidson A, Paisley S, Beverley
C, Thomas S (2003) Ultrasonic locating devices for central venous
cannulation: meta-analysis. BMJ 327:361
DISMINUCION EN EL
NUMERO DE INTENTOS
Anaesthesia, 200 4, 59, pages 1116–1120
HealthTechnology Assessment 2003;Vol. 7: No. 12
Equipo para US: 7000-15.000 Libras
Materiales para el procedimiento 1 libra
Costo procedimiento 10 L
1 maquina = 15 procedimientos semanales
90 complicaciones menos
2001
13 ECC
Modelo análisis económico
US vs técnica anatómica
X cada 1000
procedimiento se ahorran
2000 libras
(pesos 7.186.631)
Accesos Vasculares por Ultrasonografia
Karakitsos et al. Critical Care 2006,
Estudio prospectivo
Us yugular interna vs referencia anatómica
Aleatorizado 1:1
900 pte vmi uci (450 en cada grupo)
Se estratificaron en grupos Según edad, genero
IMC
5 años de experiencia
Accesos Vasculares por Ultrasonografia
Infecciones asociadas al catéter : mayor en el grupo de CVC por referencia
anatómica, se correlaciónó con el numero de punciones r= 0.65
1966 a 2013
35 ECC
5.108 pacientes
Cochrane Database Syst Rev. 2015
US Reduce el riesgo de
complicaciones 71%
(14 estudios, 2.406 pte RR 0.29 IC 0.17-0.52)
US Reduce el riesgo punciones arteriales
inadvertidas 72%
(22 estudios, 4.388 pte RR 0.28 IC 0.18-0.44)
Y la probabilidad de hematomas en 73%
(13 estudios, 3233 pte RR0.27 IC 95% O.13-0.55)
Cochrane Database Syst Rev. 2015
US Aumenta la probabilidad de
éxito en el primer intento 57%
(18estudios, 2681 pte, RR 1.57 IC 95% 1.36-
1.82)
Cochrane Database Syst Rev. 2015
US Aumenta la probabilidad de
éxito en el primer intento 57%
(18estudios, 2681 pte, RR 1.57 IC 95% 1.36-
1.82)
Cochrane Database Syst Rev. 2015
US Disminuye el tiempo 30.52
seg (-30.52 seg IC 55.2 a 5.8 seg P 0.02 )
Cochrane Database Syst Rev. 2015
Disminuye
Punción arterial
Formación de hematoma
El numero de intentos no exitosos
Tiempo de inserción del catéter
Cochrane Database Syst Rev. 2015
Br J Anaesth (2016) 116 (2): 215-222
• Estudio prospectivo aleatorizado
• 463 vmi en UCI
• Us cvc subclavio (200) vs referencia anatómica (201)
• Infraclavicular
Crit Care Med 2011; 39:1607–1612
2006-2010
Evaluaron la percepción de dificultad de los operadores.
6 años de experiencia
Accesos Vasculares por Ultrasonografia
DISMINUCION EN LAS
COMPLICACIONES
DISMINUCION EN EL
NUMERO DE INTENTOS
US 100%
LM 87.5%
Cochrane Database Syst Rev. 2015
1966 A 2013
Evaluar la efectividad y seguridad de la US para el cvc
subclavio /axilar o femoral l
Vena subclavia :
Calidad de la evidencia: Baja
9 estudios : 2030 pacientes y 2049 procedimientos
Cochrane Database Syst Rev. 2015
Reducción de punción arterial: 3 estudios 498 pacientes
RR 0.21 (0.06 a 0.82 P= 0.02 , I² = 0%).
Reducción en la formación de hematomas:
RR 0.26, 95% CI 0.09 to 0.76; P valor 0.01, I² = 0%).
No diferencias en el numero de intentos
Cochrane Database Syst Rev. 2015
4 estudios 311 procedimientos /pacientes
No diferencias en la punción inadvertida arterial
Inserción del catéter en primer intento fue mayor que con la
técnica de referencia anatómica en 3 estudios 224 pacientes
RR 1.73, 95% CI 1.34 to 2.22; P < 0.0001, I² = 31%
Ann Ernerg Med March 1997;29:331-337
Prospectivo aleatorizado
20 pacientes en paro
Ann Ernerg Med March 1997;29:331-337
Éxito: 90% vs 65%
En menor tiempo
Menos #punciones : 2.3 vs 5
Ninguna punción arterial vs 20
Guidance on the use of ultrasound locating devices for placing central venous catheters . NICE 2002
Anesthesiology 2012; 116:539 –73
Yugular interna A1
Subclavio A2
Femoral A3
Nivel A
Accesos Vasculares por Ultrasonografia

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Accesos Vasculares por Ultrasonografia

  • 5. Parienti JJ. Et al .N Engl J Med 2015;373:1220-9. 15%
  • 8. CHEST 2016; 149(1):166-179 Riesgos y ventajas asociadas a la inserción de línea arterial por el método de palpación vs US 20 estudios N = 1990 2003 al 2015
  • 10. US Disminuye el numero de intentos CHEST 2016; 149(1):166-179
  • 13. 7 Estudios 289 pacientes US vs método tradicional
  • 14. Aumenta probabilid ad de éxito 107/136 US vs 84/136 a ciegas OR 2.42
  • 15. Intensive Care Med (2012) 38:1105–111 La Lamperti M et al
  • 16. Intensive Care Med (2012) 38:1105–111 • Debe ser usado rutinariamente (A) • PICC se debe colocar con eco (A) • Si se anticipa una línea arterial difícil, se debe considerar US (B) • La línea arterial con eco mejora el éxito de la anulación (A) • Si hay sospecha de neumotórax post punción, realizar US de pulmón (B) • Es costo efectivo (A) La Lamperti M et al
  • 17. Critical Care Medicine.1996; 24(12):2053-2058 8 estudios 247Y 255 US vs técnica con referencia anatómica -Yugular -Subclavio • Intentos fallidos • Complicaciones
  • 19. REDUCE EL RIESGO DE INTENTOS FALLIDOS DISMINUCION DE LAS COMPLICACIONES 9 seg mas rápido la US
  • 20. 18 estudios 1646 pacientes US vs técnica con referencia anatómica -Yugular -Subclavio -Femoral
  • 21. Hind D, Calvert N, McWilliams R, Davidson A, Paisley S, Beverley C, Thomas S (2003) Ultrasonic locating devices for central venous cannulation: meta-analysis. BMJ 327:361
  • 22. REDUCE EL RIESGO DE INTENTOS FALLIDOS EN 86% DISMINUCION EN 57% DE LAS COMPLICACIONES DISMINUCION EN EL NUMERO DE INTENTOS 41%
  • 23. Hind D, Calvert N, McWilliams R, Davidson A, Paisley S, Beverley C, Thomas S (2003) Ultrasonic locating devices for central venous cannulation: meta-analysis. BMJ 327:361 DISMINUCION EN EL NUMERO DE INTENTOS
  • 24. Anaesthesia, 200 4, 59, pages 1116–1120 HealthTechnology Assessment 2003;Vol. 7: No. 12 Equipo para US: 7000-15.000 Libras Materiales para el procedimiento 1 libra Costo procedimiento 10 L 1 maquina = 15 procedimientos semanales 90 complicaciones menos 2001 13 ECC Modelo análisis económico US vs técnica anatómica X cada 1000 procedimiento se ahorran 2000 libras (pesos 7.186.631)
  • 26. Karakitsos et al. Critical Care 2006, Estudio prospectivo Us yugular interna vs referencia anatómica Aleatorizado 1:1 900 pte vmi uci (450 en cada grupo) Se estratificaron en grupos Según edad, genero IMC 5 años de experiencia
  • 28. Infecciones asociadas al catéter : mayor en el grupo de CVC por referencia anatómica, se correlaciónó con el numero de punciones r= 0.65
  • 29. 1966 a 2013 35 ECC 5.108 pacientes Cochrane Database Syst Rev. 2015
  • 30. US Reduce el riesgo de complicaciones 71% (14 estudios, 2.406 pte RR 0.29 IC 0.17-0.52)
  • 31. US Reduce el riesgo punciones arteriales inadvertidas 72% (22 estudios, 4.388 pte RR 0.28 IC 0.18-0.44) Y la probabilidad de hematomas en 73% (13 estudios, 3233 pte RR0.27 IC 95% O.13-0.55) Cochrane Database Syst Rev. 2015
  • 32. US Aumenta la probabilidad de éxito en el primer intento 57% (18estudios, 2681 pte, RR 1.57 IC 95% 1.36- 1.82) Cochrane Database Syst Rev. 2015
  • 33. US Aumenta la probabilidad de éxito en el primer intento 57% (18estudios, 2681 pte, RR 1.57 IC 95% 1.36- 1.82) Cochrane Database Syst Rev. 2015
  • 34. US Disminuye el tiempo 30.52 seg (-30.52 seg IC 55.2 a 5.8 seg P 0.02 ) Cochrane Database Syst Rev. 2015
  • 35. Disminuye Punción arterial Formación de hematoma El numero de intentos no exitosos Tiempo de inserción del catéter Cochrane Database Syst Rev. 2015
  • 36. Br J Anaesth (2016) 116 (2): 215-222
  • 37. • Estudio prospectivo aleatorizado • 463 vmi en UCI • Us cvc subclavio (200) vs referencia anatómica (201) • Infraclavicular Crit Care Med 2011; 39:1607–1612 2006-2010 Evaluaron la percepción de dificultad de los operadores. 6 años de experiencia
  • 39. DISMINUCION EN LAS COMPLICACIONES DISMINUCION EN EL NUMERO DE INTENTOS US 100% LM 87.5%
  • 40. Cochrane Database Syst Rev. 2015 1966 A 2013 Evaluar la efectividad y seguridad de la US para el cvc subclavio /axilar o femoral l Vena subclavia : Calidad de la evidencia: Baja 9 estudios : 2030 pacientes y 2049 procedimientos
  • 41. Cochrane Database Syst Rev. 2015 Reducción de punción arterial: 3 estudios 498 pacientes RR 0.21 (0.06 a 0.82 P= 0.02 , I² = 0%). Reducción en la formación de hematomas: RR 0.26, 95% CI 0.09 to 0.76; P valor 0.01, I² = 0%). No diferencias en el numero de intentos
  • 42. Cochrane Database Syst Rev. 2015 4 estudios 311 procedimientos /pacientes No diferencias en la punción inadvertida arterial Inserción del catéter en primer intento fue mayor que con la técnica de referencia anatómica en 3 estudios 224 pacientes RR 1.73, 95% CI 1.34 to 2.22; P < 0.0001, I² = 31%
  • 43. Ann Ernerg Med March 1997;29:331-337 Prospectivo aleatorizado 20 pacientes en paro
  • 44. Ann Ernerg Med March 1997;29:331-337 Éxito: 90% vs 65% En menor tiempo Menos #punciones : 2.3 vs 5 Ninguna punción arterial vs 20
  • 45. Guidance on the use of ultrasound locating devices for placing central venous catheters . NICE 2002
  • 46. Anesthesiology 2012; 116:539 –73 Yugular interna A1 Subclavio A2 Femoral A3 Nivel A

Notas del editor

  • #3: Ultrasound-guided procedures are performed by visualizing the target structure with ultrasound before beginning the procedure, followed by real-time ultrasound visualiza- tion of the needle during the procedure (dynamic guidance). Ultrasound-assisted pro- cedures are performed by visualizing the target structure with ultrasound before the procedure, and marking the site where the needle will be inserted (static guidance). The procedure is then performed without direct ultrasound visualization.1 Visualuzar la aguja como una linea o punto ecogenico brillante con ventana acustica y artefacto en anillo
  • #5: Multiple studies have shown that the use of ultrasound increases success rates and improves patient safety during central venous access attempts. Ultrasound can be used to help guide cannulation of the internal jugular (IJ) vein, femoral veins, and subclavian veins.1,12,13 When performing a central venous cannulation, ultrasound guidance with direct visualization of the needle in the vein is recommended rather than ultrasound assis- tance
  • #6: 3SITES study
  • #7: . Complications of central venous cannulation include hematoma formation, air embolism, thoracic duct fistula, pneumothorax or hemothorax, venous thrombosis, infection, catheter embolism, myocardial puncture, hydromediastinum, and hydrotho- rax. Performing the procedure under dynamic guidance greatly reduces some of these complication rates.1,12–15 Despite advances with ultrasound guidance, accidental arterial puncture can still occur. Performing the procedure in a dynamic fashion in the long-axis approach can help reduce the chances of accidental arterial puncture.
  • #8: success significantly depends on patient anatomy, comorbid conditions and operator skill
  • #9: Potential benefits and possible risks associated with ultrasound guidance compared with traditional palpation for radial artery catheterization are not fully understood. METHODS: We searched PubMed, Embase, and the Cochrane Library through July 2015 to identify randomized controlled trials that evaluated ultrasound guidance compared with traditional palpation for radial artery catheterization. Primary outcome was first-attempt failure. Secondary outcomes included mean attempts to success, mean time to success, and hematoma complications. A random-effects model was used to estimate relative risks (RRs) with 95% CIs. RESULTS: Twelve trials used dynamic two-dimensional (2-D) ultrasound guidance (N = 1,992) and two used Doppler ultrasound guidance (N = 666). Compared with traditional palpation, dynamic 2-D ultrasound guidance was associated with a reduced first-attempt failure (RR, 0.68; 95% CI, 0.52-0.87). Trial sequential analysis showed that the cumulative z curve crossed the trial sequential monitoring boundary for benefit establishing
  • #10: Primary Outcome: First-Attempt Failure: Twelve trials totaling 1,992 patients provided data on first-attempt failure.9,11-17,21-24 Compared with traditional palpation, dynamic 2-D ultrasound significantly reduced first-attempt failure (RR, 0.68; 95% CI, 0.52-0.87; P ¼ .003) (Fig 2), with significant heterogeneity (I 2 ¼ 72%). TSA showed that the cumulative z curve crossed both the conventional boundary for benefit and the
  • #11: Secondary Outcomes: Compared with traditional palpation, dynamic 2-D ultrasound guidance for radial artery catheterization further reduced mean attempts to success (MD, –1.26 times; 95% CI, –1.58 to –0.94 times; P < .00001) (Fig 4), mean time to success (MD, –43.18 s; 95% CI, –80.22 to –6.13 s; P ¼ .02) (Fig 5), and hematoma complications (RR, 0.39; 95% CI, 0.16-0.95; P ¼ .04) (Fig 6).
  • #12: ), mean time to success (MD, –43.18 s; 95% CI, –80.22 to –6.13 s; P ¼ .02) (Fig 5), and hematoma complications (RR, 0.39; 95% CI, 0.16-0.95; P ¼ .04) (Fig 6).
  • #14: trials were identified (289 participants). Ultrasound guidance increases the likelihood of successful cannulation (pooled OR 2.42; 95% CI 1.26 to 4.68; p1⁄40.008). There were no differences in time to successful cannulation, or number of percutaneous skin punctures.
  • #15: Primary outcome: successful cannulation Six out of the seven studies3 22e26 reported on cannulation success using Ultrasound guidance versus the standard tech- nique. Ultrasound-guidance was found to increase the likelihood of successful cannulation (107/136 Ultrasound group vs 84/136 ST group; pooled OR 2.42; 95% CI 1.26 to 4.68; p1⁄40.008). There was no evidence of heterogeneity (Cochran’s Q 1.79, 5 df, p1⁄40.144) or bias (Egger test 1⁄4 0.25 p1⁄40.69). The funnel plot was symmetrical overall (figures 1e4)
  • #29: Average access time and number of attempts were both significantly reduced using ultrasound compared with the landmark technique (p < 0.001) It is of note that the number of CVC-BSIs was positively correlated to the number of needle passes in the total study population (r = 0.65, p < 0.001).
  • #30: Use of two-dimensional ultrasound reduced the rate of total complications overall by 71% (14 trials, 2406 participants, risk ratio (RR) 0.29, 95% confidence interval (CI) 0.17 to 0.52; P value < 0.0001, I² = 57%), and the number of participants with an inadvertent arterial puncture by 72% (22 trials, 4388 participants, RR 0.28, 95% CI 0.18 to 0.44; P value < 0.00001, I² = 35%). Overall success rates were modestly increased in all groups combined at 12% (23 trials, 4340 participants, RR 1.12, 95% CI 1.08 to 1.17; P value < 0.00001, I² = 85%), and similar benefit was noted across all subgroups. The number of attempts needed for successful cannulation was decreased overall (16 trials, 3302 participants, mean difference (MD) -1.19 attempts, 95% CI -1.45 to -0.92; P value < 0.00001, I² = 96%) and in all subgroups. Use of two-dimensional ultrasound increased the chance of success at the first attempt by 57% (18 trials, 2681 participants, RR 1.57, 95% CI 1.36 to 1.82; P value < 0.00001, I² = 82%) and reduced the chance of haematoma formation (overall reduction 73%, 13 trials, 3233 participants, RR 0.27, 95% CI 0.13 to 0.55; P value 0.0004, I² = 54%). Use of two-dimensional ultrasound decreased the time to successful cannulation by 30.52 seconds (MD -30.52 seconds, 95% CI -55.21 to -5.82; P value 0.02, I² = 97%). Additional data are available to support use of ultrasound during, not simply before, line insertion.
  • #32: and reduced the chance of haematoma formation (overall reduction 73%, 13 trials, 3233 participants, RR 0.27, 95% CI 0.13 to 0.55; P value 0.0004, I² = 54%). Use of two-dimensional ultrasound decreased the time to successful cannulation by 30.52 seconds (MD -30.52 seconds, 95% CI -55.21 to -5.82; P value 0.02, I² = 97%). Additional data are available to support use of ultrasound during, not simply before, line insertion.
  • #33: Overall success rates were modestly increased in all groups combined at 12% (23 trials, 4340 participants, RR 1.12, 95% CI 1.08 to 1.17; P value < 0.00001, I² = 85%), and similar benefit was noted across all subgroups. The number of attempts needed for successful cannulation was decreased overall (16 trials, 3302 participants, mean difference (MD) -1.19 attempts, 95% CI -1.45 to -0.92; P value < 0.00001, I² = 96%) and in all subgroups. Use of two-dimensional ultrasound increased the chance of success at the first attempt by 57% (18 trials, 2681 participants, RR 1.57, 95% CI 1.36 to 1.82; P value < 0.00001, I² = 82%) and reduced the chance of haematoma formation (overall reduction 73%, 13 trials, 3233 participants, RR 0.27, 95% CI 0.13 to 0.55; P value 0.0004, I² = 54%). Use of two-dimensional ultrasound decreased the time to successful cannulation by 30.52 seconds (MD -30.52 seconds, 95% CI -55.21 to -5.82; P value 0.02, I² = 97%). Additional data are available to support use of ultrasound during, not simply before, line insertion.
  • #34: Use of two-dimensional ultrasound increased the chance of success at the first attempt by 57% (18 trials, 2681 participants, RR 1.57, 95% CI 1.36 to 1.82; P value < 0.00001, I² = 82%) The number of attempts needed for successful cannulation was decreased overall (16 trials, 3302 participants, mean difference (MD) -1.19 attempts, 95% CI -1.45 to -0.92; P value < 0.00001, I² = 96%) and in all subgroups. Use of two-dimensional ultrasound increased the chance of success at the first attempt by 57% (18 trials, 2681 participants, RR 1.57, 95% CI 1.36 to 1.82; P value < 0.00001, I² = 82%) and reduced the chance of haematoma formation (overall reduction 73%, 13 trials, 3233 participants, RR 0.27, 95% CI 0.13 to 0.55; P value 0.0004, I² = 54%). Use of two-dimensional ultrasound decreased the time to successful cannulation by 30.52 seconds (MD -30.52 seconds, 95% CI -55.21 to -5.82; P value 0.02, I² = 97%). Additional data are available to support use of ultrasound during, not simply before, line insertion.
  • #35: Use of two-dimensional ultrasound decreased the time to successful cannulation by 30.52 seconds (MD -30.52 seconds, 95% CI -55.21 to -5.82; P value 0.02, I² = 97%). Additional data are available to support use of ultrasound during, not simply before, line insertion.
  • #36: . Based on available data, we conclude that two-dimensional ultrasound offers gains in safety and quality when compared with an anatomical landmark technique. Because of missing data, we did not compare effects with experienced versus inexperienced operators for all outcomes (arterial puncture, haematoma formation, other complications, success with attempt number one), and so the relative utility of ultrasound in these groups remains unclear and no data are available on use of this technique in patients at high risk of complications. The results for Doppler ultrasound techniques versus anatomical landmark techniques are also uncerta
  • #41: Altogether 13 studies enrolling 2341 participants (and involving 2360 procedures) fulfilled the inclusion criteria. The quality of evidence was very low (subclavian vein N = 3) or low (subclavian vein N = 4, femoral vein N = 2) for most outcomes, moderate for one outcome (femoral vein) and high at best for two outcomes (subclavian vein N = 1, femoral vein N = 1). Most of the trials had unclear risk of bias across the six domains, and heterogeneity among the studies was significant.For the subclavian vein (nine studies, 2030 participants, 2049 procedures), two-dimensional ultrasound reduced the risk of inadvertent arterial puncture (three trials, 498 participants, risk ratio (RR) 0.21, 95% confidence interval (CI) 0.06 to 0.82; P value 0.02, I² = 0%) and haematoma formation (three trials, 498 participants, RR 0.26, 95% CI 0.09 to 0.76; P value 0.01, I² = 0%). No evidence was found of a difference in total or other complications (together, US, USD), overall (together, US, USD), number of attempts until success (US) or first-time (US) success rates or time taken to insert the catheter (US).For the femoral vein, fewer data were available for analysis (four studies, 311 participants, 311 procedures). No evidence was found of a difference in inadvertent arterial puncture or other complications. However, success on the first attempt was more likely with ultrasound (three trials, 224 participants, RR 1.73, 95% CI 1.34 to 2.22; P value < 0.0001, I² = 31%), and a small increase in the overall success rate was noted (RR 1.11, 95% CI 1.00 to 1.23; P value 0.06, I² = 50%). No data on mortality or participant-reported outcomes were provided.
  • #42: Most of the trials had unclear risk of bias across the six domains, and heterogeneity among the studies was significant.For the subclavian vein (nine studies, 2030 participants, 2049 procedures), two-dimensional ultrasound reduced the risk of inadvertent arterial puncture (three trials, 498 participants, risk ratio (RR) 0.21, 95% confidence interval (CI) 0.06 to 0.82; P value 0.02, I² = 0%) and haematoma formation (three trials, 498 participants, RR 0.26, 95% CI 0.09 to 0.76; P value 0.01, I² = 0%). No evidence was found of a difference in total or other complications (together, US, USD), overall (together, US, USD), number of attempts until success (US) or first-time (US) success rates or time taken to insert the catheter (US).For the femoral vein, fewer data were available for analysis (four studies, 311 participants, 311 procedures). No evidence was found of a difference in inadvertent arterial puncture or other complications. However, success on the first attempt was more likely with ultrasound (three trials, 224 participants, RR 1.73, 95% CI 1.34 to 2.22; P value < 0.0001, I² = 31%), and a small increase in the overall success rate was noted (RR 1.11, 95% CI 1.00 to 1.23; P value 0.06, I² = 50%). No data on mortality or participant-reported outcomes were provided.
  • #43: For the femoral vein, fewer data were available for analysis (four studies, 311 participants, 311 procedures). No evidence was found of a difference in inadvertent arterial puncture or other complications. However, success on the first attempt was more likely with ultrasound (three trials, 224 participants, RR 1.73, 95% CI 1.34 to 2.22; P value < 0.0001, I² = 31%), and a small increase in the overall success rate was noted (RR 1.11, 95% CI 1.00 to 1.23; P value 0.06, I² = 50%). No data on mortality or participant-reported outcomes were provided.
  • #47: rates of arterial puncture (Category A1 evidence). Randomized controlled trials report fewer number of insertion attempts with real-time ultrasound guided venipuncture of the internal jugular vein (Category A2 evidence).97,99,103,104 For the subclavian vein, randomized controlled trials report fewer insertion attempts with real-time ultrasound guided venipuncture (Category A2 evidence),105,106 and one randomized clinical trial indicates a higher success rate and reduced access time, with fewer arterial punctures and hematomas compared with the anatomic landmark approach (Category A3 evidence).106 For the femoral vein, a randomized controlled trial reports a higher first-attempt success rate and fewer needle passes with real-time ultrasound guided venipuncture compared with the anatomic landmark approach in pediatric patients (Category A3 evidence).107