Physical Pharmaceutics-II Lab Manual as per the PCI Syllabus

Physical Pharmaceutics-II Lab Manual as per the PCI Syllabus

Physical Pharmaceutics-II Lab Manual as per the PCI Syllabus

Dr. A. Pavani

SMART MOVES PUBLICATION E 5/11, 2nd Floor , Bitten Market Bhopal-462038, India [email protected] www.smartmovesonline.org

Contents

1 Determination of particle size, particle size distribution using sieving method

2 Determination Of Particle Size And Size Distribution By Microscopy

3 Determination of bulk density, true density and porosity

4 Determination of Angle of repose

5 Determination of influence of lubricants on angle of repose.

6 Determination of viscosity of liquid using Ostwald’s viscometer

7 Determination of sedimentation volume with effect of different suspending agents

8 Determination of sedimentation volume with effect of different concentrations of single suspending agent.

9 Brookfield Viscometer

10 Determination of reaction rate constant first order

11 Determination of reaction rate constant second order

12 Second Order Reaction Kinetics

13 Accelerated Stability Studies

Book Title: Physical Pharmaceutics-II lab manual as per the PCI syllabus

Published by SMART MOVES

E 5/11, 2nd Floor, Bitten Market

Bhopal-462038

India

Printed and bound by SMART MOVES

E 5/11, 2nd Floor, Bitten Market

Bhopal-462038

India

ISBN:978-81-940996-4-2

This edition published in: 2020 ISBN (ISBN Pending)

Copyright ©2020 by Dr. A.Pavani,

Dr. A.Pavani, asserts the moral right to be identified as the author of this work.

This book is a work of fiction and any resemblance to actual persons, living or dead, events and locales is purely coincidental.

All rights reserved. No part of this publication may be reproduced, stored in or introduced into a retrieval system, or transmitted, in any form, or by any means (electrical, mechanical, photocopying, recording or otherwise) without the prior written permission of the author or publisher. Any person who does any unauthorised act in relation to this publication may be liable to criminal prosecution and civil claims for damages.

1

Determination of particle size, particle size distribution using sieving method

Aim: To determine the size distribution of particle in the given sample (Powder or granules). 

Principle:  Sieving method gives diameter, dsieve. Sieve diameter is defined as the diameter of a sphere that passes through the sieve aperture as the asymmetric particle.

Sieving method directly gives weight distribution. Standard sieves of different mesh numbers are available commercially as per the specification of IP and USP (Table no 1.1 and 1.2). Sieves are arranged in a nest with the coarsest at the top. A sample (50.0 g) of the powder (or granules) is placed on the top sieve. This sieve set is fixed to the mechanical shaker apparatus and shaker for a period time (20 minutes). The powder retained on each sieve is weighed. Then different size distribution curves are constructed.

Construction of Sieves: Sieves for pharmaceutical testing are constructed from wire cloth with square meshes, Woven from wire of brass, bronze, stainless steel or other suitable materials.

Factors Influencing the Sieving: Factors influencing sieving are weight of sample, duration of shaking and type of motion.  The types of motion influencing sieving are vibratory motion (most efficient), side-tap motion, bottom pat motion (intensity) of the shaker is