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Ivermectin

Ivermectin is a well-tolerated drug that is effective for treating hookworm folliculitis and onchocerciasis by paralyzing worms and killing microfilariae, though repeated treatments may be necessary for hookworm and it is contraindicated for young children, pregnant, and breastfeeding women. Ivermectin works by intensifying GABA transmission to effectively paralyze and kill parasites, blocking nerve signals and peripheral release of GABA, with microfilariae in the skin rapidly diminishing within days of a single dose and remaining low for months.

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Sundhias Larashati
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176 views1 page

Ivermectin

Ivermectin is a well-tolerated drug that is effective for treating hookworm folliculitis and onchocerciasis by paralyzing worms and killing microfilariae, though repeated treatments may be necessary for hookworm and it is contraindicated for young children, pregnant, and breastfeeding women. Ivermectin works by intensifying GABA transmission to effectively paralyze and kill parasites, blocking nerve signals and peripheral release of GABA, with microfilariae in the skin rapidly diminishing within days of a single dose and remaining low for months.

Uploaded by

Sundhias Larashati
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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Ivermectin

Is the drug may of choice, very well in tolerated, and no significant adverse effects have been reported. Repeated treatment be necessary hookworm folliculitis. Ivermectin is contraindicated in children who weigh less than 15 kg (or are less than 5 years of age) and in pregnant or breastfeeding women. Mechanism of action : Ivermectin appears to paralyze nematodes and arthropods by intensifying transmission effectively kill -aminobutyric of signals worms in but acid (GABA)-mediated nerves. release In of peripheral blocks the

onchocerciasis, ivermectin in microfilaricidal. It does not adult microfilariae for some months after therapy. After a single standard dose, microfilariae in the skin diminish rapidly within 2-3 days, remain low for months, and then gradually increase; microfilariae in the anterior chamber of the eye decrease slowly over months, eventually clear, and then gradually return.

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