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Paracetamol

Paracetamol is a non-opioid analgesic used to treat mild to moderate pain and fever by inhibiting prostaglandins and other substances that sensitize pain receptors and regulating hypothalamic heat centers. It can cause hematologic and hepatic adverse reactions and interact with other drugs. Paracetamol is contraindicated in hypersensitivity and used cautiously in liver disease, and dosing varies based on age and condition.

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Muhammad Arsalan
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547 views

Paracetamol

Paracetamol is a non-opioid analgesic used to treat mild to moderate pain and fever by inhibiting prostaglandins and other substances that sensitize pain receptors and regulating hypothalamic heat centers. It can cause hematologic and hepatic adverse reactions and interact with other drugs. Paracetamol is contraindicated in hypersensitivity and used cautiously in liver disease, and dosing varies based on age and condition.

Uploaded by

Muhammad Arsalan
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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PARACETAMOL

Therapeutic Category Non opioid analgesics Agent Pharmacologic class: Para-aminophenol derivative Use\ Indications Mild to moderate pain, pyrexia Pharmacological Effects Produces analgesia by inhibiting prostaglandin and other substances that sensitize pain receptors. Drug may relieve fever through central action in the hypothalamic heat-regulating center. Adverse Reactions Hematologic: hemolytic anemia, leukopenia, neutropenia, pancytopenia. Hepatic: jaundice. Metabolic: hypoglycemia. Skin: rash, urticarial Precautions/Warnings/Contraindication May decrease glucose and hemoglobin levels and hematocrit. May decrease neutrophil, WBC, RBC and platelet counts Contraindicated in patients hypersensitive to drug. Use cautiously in patients with any type of liver disease Pregnancy category: B Breast-feeding: amount too small to be harmful Interactions: Barbiturates, carbamazepine,hydantoins, rifampin, sulfinpyrazone, Lamotrigine, zidovudine Warfarin: May increase hypoprothrombinemic effects Dosing Children(<3months): 10-15mg/kg every 4 to 6 hrs Adult: 325-650mg every 4 to 6 hrs Max. Dose 4gm per gm day Brand Available: Tablets Panadol-500mg , Pandol CF, Panadol Extra(P+caffeine) Febrol Nuberol(Paracetamol 450mg+orphenedrine), Nuberol Forte Duragesic (P+orphenedrine) Cofcol (P+pseudoephedrine) Parentrals Bofalgan 1gm

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