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Drug Indication Adverse Effects Nursing Consideration

Vitamin K3 (Menadione) is a synthetic analogue of Vitamin K used to treat Vitamin K deficiency caused by conditions that impair fat absorption like malabsorption syndrome or cholestasis. It works slowly over 2-3 days by influencing the hepatic enzyme system. Potential adverse effects include cytotoxicity in liver cells, weakening of the immune system, possible mutagenic effects, and disturbances in calcium ion levels. Nursing considerations include monitoring for signs of adverse effects and instructing patients on the slow onset of action.

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133 views2 pages

Drug Indication Adverse Effects Nursing Consideration

Vitamin K3 (Menadione) is a synthetic analogue of Vitamin K used to treat Vitamin K deficiency caused by conditions that impair fat absorption like malabsorption syndrome or cholestasis. It works slowly over 2-3 days by influencing the hepatic enzyme system. Potential adverse effects include cytotoxicity in liver cells, weakening of the immune system, possible mutagenic effects, and disturbances in calcium ion levels. Nursing considerations include monitoring for signs of adverse effects and instructing patients on the slow onset of action.

Uploaded by

Sheng Gosep
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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DRUG GENERIC NAME: Vitamin K3 BRAND NAME: Menadione CLASSIFICATION:

INDICATION

ADVERSE EFFECTS

NURSING CONSIDERATION

Insufficient production of
Vitamin K in the large intestine hemorrhagic diathesis disturbances of fat absorption Treatment with broad-spectrum antibiotics and sulfonamides leading to destruction of the intestinal flora.

causes cytotoxicity in liver cells causes formation of radicals from


enzymes of leucocytes, with the consequence of cytotoxic reactions considerably weakens the immune system possible mutagenic effects damages the natural vitamin K cycle has no effect on coumarin derivatives, which are often present in commercial food due to mold contamination (toxic when ingested) causes hemolytic anemia and hyperbilirubinemia, not just linked to large doses disturbs the level of calcium ions (Ca2+) in the body, which is an important factor fibrinolysis is directly toxic in high doses (vomiting, albuminuria), unlike natural vitamin K builds up in tissue and has been detected in eggs, meat and milk of animals supplemented with menadione derivatives causes irritation of skin and mucous membranes causes allergic reactions and eczema

STOCK DOSE: 10 mg/ml in 1 amp


DRUG ACTION

CONTRAINDICATIONS

PATIENT TEACHING

Vitamin K3 is a synthetic analogue of Vitamin K. The advantage of the drug is its water-solubility which determines its use as an agent of choice in Vitamin K deficiency caused by "malabsorption " syndrome, cholestatis, etc. The effect of the drug is attained 2-3 days after its administration, because the process of influencing the hepatic enzyme system is slow.

None reported so far.

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