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Crest or

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57 views

Crest or

Uploaded by

ianecunar
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
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Brand Name: Crestor

Generic Name: Rosuvastatin


Indications: Adjunct to dietary therapy in the management of primary hypercholesterolemia and mixed
dyslipidemias. Reduction of lipids/cholesterol reduces the risk of MI and stroke sequelae
(primary prevention and secondary prevention) nd decreases the need for bypass
procedures/angioplasty.
Drug Classification: Lipid-lowering agents, HMG-CoA reductase inhibitors
Mechanism of Action: Inhibit an enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)
reductase, which is responsible for catalyzing an early step in the synthesis of cholesterol.
Therapeutic effects: Lowering of total and LDL cholesterol; Increase HDL and
decrease VDDL cholesterol and triglycerides; Slowing of the progression of coronary
artery disease with resultant decrease in MI/stroke and need for myocardial
revascularization.
Dosage: Adult: 10 mg od initially (range 5-20 mg); dose may be adjusted at 2-4 wk intervals; some
patients may require up to 40 mg/day; concurrent cyclosporine therapy – not to exceed 5
mg od; concurrent gemfibrozil therapy – not to exceed 10 mg od.
Special Precautions: History of liver disease or significant alcohol use/abuse; patients with Asian
ancestry (may have high blood levels); renal impairement, advanced age or
hypothyroidism; visual disturbances; myopathy; women of childbearing age; children <8
yr.
Pregnancy Risk Category: X
Adverse Reactions:
CNS: dizziness, headache, insomia, weakness
EENT: rhinitis, Resp: Bronchitis
GI: abdominal cramps, constipation, diarrhea, flatus, heartburn, altered taste, drug-induced
hepatitis, dyspepsia, elevated liver enzymes, nausea, pancreatitis
GU: impotence, Derm: rashes, pruritus
MS: Rhabdomyolysis, arthralgia, arthritis, myalgia, myositis
Misc: hypersensitivity reactions.
Contraindications: Hypersensitivity, cross-sensitivity among agents may occur; sepsis, acute
hypotension, major surgery, trauma, severe metabolic disturbances, endocrine or
electrolyte disorders, uncontrolled seizures; active liver disease; pregnancy or lactation;
concurrent use of gemfibrozil or azole antifungals.
Forms: Tablets – 5 mg, 10 mg, 20 mg, 40 mg
Nursing Responsibilities:
 Obtain a dietary history, especially with regard to fat consumption.
 Opthalmic exams are recommended before and yearly during therapy.
 If patients develop muscle tenderness during therapy, monitor CPK levels.
 May cause thyroid function test abnormalities.
 Instruct patient to notify health care professionals if unexplained muscle pain,
tenderness, or weakness occurs, especially if accompanied by fever or malaise.
 Instruct client to wear sunscreen and protective clothing to prevent photosensitivity
reactions.

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