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P4: Computational Methods / Sem-Iv / Siddy

The document outlines the units to be covered in a computational methods course. Unit I introduces biostatistics topics like probability, distributions, regression, experimental design and tests of significance. Unit II covers computer basics, hardware components, software, and networking. Unit III discusses the history of sequencing proteins and DNA, biological databases, and tools for sequence alignment and phylogenetic analysis. Unit IV applies bioinformatics to genomics, proteomics, structure prediction, and pharmacogenomics.

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vsiddharthareddy
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42 views

P4: Computational Methods / Sem-Iv / Siddy

The document outlines the units to be covered in a computational methods course. Unit I introduces biostatistics topics like probability, distributions, regression, experimental design and tests of significance. Unit II covers computer basics, hardware components, software, and networking. Unit III discusses the history of sequencing proteins and DNA, biological databases, and tools for sequence alignment and phylogenetic analysis. Unit IV applies bioinformatics to genomics, proteomics, structure prediction, and pharmacogenomics.

Uploaded by

vsiddharthareddy
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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P4: COMPUTATIONAL METHODS / SEM-IV / SIDDY UNIT-I: BIOSTATICSTICS

Statistics. Introduction to Statistics. Probability & Randomness. Distribution Normal Pioisson & Binomial Mean Mode & Range. Standard deviation & Error. Regression Co-efficient & Use regression for Linear Data. Experimental design. Sampling. Methods of data Presentation. Graphs & histograms. Tests of Significance & Correlation. Coefficient of Variation Students T & Chi-square Test.

UNIT- II: COMPUTER BASICS Elements of Computer Science. General Awareness of Development of Computers.
Main frame, Minis, Micros & Super Computer systems. CPU & peripherals I/O auxiliary storage. Software & Programming Languages. (Machine Assembly & Higher level) Popular Software Packages for use in Biology Networking concepts & its use in data search.

UNIT-III: BASICS OF BIOINFORMATICS


Historical review for sequencing of proteins & DNA to genomics. Proteomics, Array Analysis, Drug design etc.. Biological Databases( DNA: protein): Public & Restricted EMBL,SWISSPROT etc. Retrieval, alignment & Comparison of sequences pair wise. BLAST. FASTA: Cluster: algorithms for phylogenetic comparison & analysis.

UNIT-IV: APPLICATIONS OF BIOINFORMATICS


Introduction to genomics: Genome Microarrays. Genome Sequencing HUGO HUPO Functional genomics: Transcription Genomic Comparison. ESTs finding regulatory sites repetitive elements. Proteomics: sequence to structure & modeling: secondary & tertiary structure prediction of proteins. Motifs Methods for threading tertiary structure. Pharmacogenomics & drug design. Software for identification of protein based on molecular weight. Peptide finger print. amino acid & nucleotide sequence of DNA/RNA.

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