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M.SC - Micro Project 2

The document discusses sepsis, including: - Sepsis has an incidence of 3 per 1,000 people worldwide, with an estimated 18 million cases per year, making it a leading cause of death. - Risk factors for developing sepsis include advanced age, medical procedures/surgery, alcohol abuse, diabetes, burns, weakened immune system, and certain medications. - Symptoms of sepsis can include fever, rapid heartbeat, fast breathing, low blood pressure, sweating, confusion and symptoms related to the site of infection.

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Hanumant Suryawanshi
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15 views

M.SC - Micro Project 2

The document discusses sepsis, including: - Sepsis has an incidence of 3 per 1,000 people worldwide, with an estimated 18 million cases per year, making it a leading cause of death. - Risk factors for developing sepsis include advanced age, medical procedures/surgery, alcohol abuse, diabetes, burns, weakened immune system, and certain medications. - Symptoms of sepsis can include fever, rapid heartbeat, fast breathing, low blood pressure, sweating, confusion and symptoms related to the site of infection.

Uploaded by

Hanumant Suryawanshi
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Epidemiology

The Surviving Sepsis Campaign (SSC) estimates that the incidence of sepsis is 3 per 1,000 worldwide. Thus the number of cases each year probably reaches 18 million and this, associated with its high mortality rate, makes it a leading cause of death.[3]
Risk factors

There is usually an abscess or nidus of infection, which may be occult. Risk factors for developing sepsis include the following:

Age - elderly and very young at risk. Instrumentation or surgery (including illegal abortion occurring in unhygienic circumstances). Ethanol abuse. Diabetes mellitus. Burns. Immunocompromise. Medications, eg high dose corticosteroids, chemotherapy.

Presentation

Patients may present a few days earlier with a focus of infection. Patients may then deteriorate rapidly despite having the appropriate oral antibiotics. Nonspecific symptoms are common, eg lethargy, nausea and vomiting, abdominal pain and diarrhoea. Also inquire about symptoms relating to a possible focus of infection, eg cough, recent travel.

Clinical features

Looks unwell. Fever (maybe spiking) and/or rigors. Tachycardia, tachypnoea and cyanosis. Hyperdynamic circulation with a bounding pulse (early on). Poor capillary refill and cold peripheries occur later. Hypotension with a postural drop (indicates septic shock). Sweating. Lymphadenopathy. Hepatosplenomegaly. Drowsiness or impaired consciousness (common in the elderly but a late sign in young children and young adults). Features relating to actual infection, eg rash in meningococcal sepsis, dullness to percussion in pneumonia.

These features may not be present in the very young, elderly and immunocompromised

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