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Biotech Syllabus GATE2010

The document provides an overview of the topics covered in the biotechnology syllabus for the GATE exam, including linear algebra, calculus, differential equations, probability and statistics, microbiology, biochemistry, molecular biology, genetics, process biotechnology, bioprocess engineering, plant and animal biotechnology, immunology, recombinant DNA technology, and bioinformatics.

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204 views

Biotech Syllabus GATE2010

The document provides an overview of the topics covered in the biotechnology syllabus for the GATE exam, including linear algebra, calculus, differential equations, probability and statistics, microbiology, biochemistry, molecular biology, genetics, process biotechnology, bioprocess engineering, plant and animal biotechnology, immunology, recombinant DNA technology, and bioinformatics.

Uploaded by

swarup0004
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as PDF, TXT or read online on Scribd
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Biotechnology(BT) syllabus for GATE:

Linear Algebra: Matrices and determinants, Systems of linear equations, Eigen values
and Eigen vectors.

Calculus : Limit, continuity and differentiability, Partial derivatives, Maxima and minima,
Sequences and series, Test for convergence, Fourier Series.

Differential Equations : Linear and nonlinear first order ODEs, higher order ODEs with
constant coefficients, Cauchy’s and Euler’s equations, Laplace transforms, PDE- Laplace,
heat and wave equations.

Probability and Statistics: Mean, median, mode and standard deviation, Random
variables, Poisson, normal and binomial distributions, Correlation and regression analysis.

Numerical Methods: Solution of linear and nonlinear algebraic equations, Integration of


trapezoidal and Simpson’s rule, Single and multistep methods for differential equations.

Microbiology: Prokaryotic and eukaryotic cell structure; Microbial nutrition, growth and
control; Microbial metabolism (aerobic and anaerobic respiration, photosynthesis); Nitrogen
fixation; Chemical basis of mutations and mutagens; Microbial genetics (plasmids,
transformation, transduction, conjugation); Microbial diversity and characteristic features;
Viruses.

Biochemistry: Biomolecules and their conformation; Ramachandran map; Weak inter-


molecular interactions in biomacromolecules; Chemical and functional nature of enzymes;
Kinetics of single substrate and bi-substrate enzyme catalyzed reactions; Bioenergetics;
Metabolism (Glycolysis, TCA and Oxidative phosphorylation); Membrane transport and
pumps; Cell cycle and cell growth control; Cell signaling and signal transduction;
Biochemical and biophysical techniques for macromolecular analysis.

Molecular Biology and Genetics: Molecular structure of genes and chromosomes; DNA
replication and control; Transcription and its control; Translational processes; Regulatory
controls in prokaryotes and eukaryotes; Mendelian inheritance; Gene interaction;
Complementation; Linkage, recombination and chromosome mapping; Extrachromosomal
inheritance; Chromosomal variation; Population genetics; Transposable elements,
Molecular basis of genetic diseases and applications.

Process Biotechnology: Bioprocess technology for the production of cell biomass and
primary/secondary metabolites, such as baker’s yeast, ethanol, citric acid, amino acids, exo-
polysacharides, antibiotics and pigments etc.; Microbial production, purification and
bioprocess application(s) of industrial enzymes; Production and purification of recombinant
proteins on a large scale; Chromatographic and membrane based bioseparation methods;
Immobilization of enzymes and cells and their application for bioconversion processes.
Aerobic and anaerobic biological processes for stabilization of solid / liquid wastes;
Bioremediation.

Bioprocess Engineering: Kinetics of microbial growth, substrate utilization and product


formation; Simple structured models; Sterilization of air and media; Batch, fed-batch and
continuous processes; Aeration and agitation; Mass transfer in bioreactors; Rheology of
fermentation fluids; Scale-up concepts; Design of fermentation media; Various types of
microbial and enzyme reactors; Instrumentation in bioreactors.

Plant and Animal Biotechnology: Special features and organization of plant cells;
Totipotency; Regeneration of plants; Plant products of industrial importance; Biochemistry
of major metabolic pathways and products; Autotrophic and heterotrophic growth; Plant
growth regulators and elicitors; Cell suspension culture development: methodology, kinetics
of growth and production formation, nutrient optimization; Production of secondary
metabolites by plant suspension cultures; Hairy root cultures and their cultivation.
Techniques in raising transgencies. Characteristics of animal cells: Metabolism, regulation
and nutritional requirements for mass cultivation of animal cell cultures; Kinetics of cell
growth and product formation and effect of shear force; Product and substrate transport;
Micro & macro-carrier culture; Hybridoma technology; Live stock improvement; Cloning in
animals; Genetic engineering in animal cell culture; Animal cell preservation.

Immunology: The origin of immunology; Inherent immunity; Humoral and cell mediated
immunity; Primary and secondary lymphoid organ; Antigen; B and T cells and
Macrophages; Major histocompatibility complex (MHC); Antigen processing and
presentation; Synthesis of antibody and secretion; Molecular basis of antibody diversity;
Polyclonal and monoclonal antibody; Complement; Antigen-antibody reaction; Regulation of
immune response; Immune tolerance; Hyper sensitivity; Autoimmunity; Graft versus host
reaction.

Recombinant DNA Technology: Restriction and modification enzymes; Vectors:


plasmid, bacteriophage and other viral vectors, cosmids, Ti plasmid, yeast artificial
chromosome; cDNA and genomic DNA library; Gene isolation; Gene cloning; Expression of
cloned gene; Transposons and gene targeting; DNA labeling; DNA sequencing; Polymerase
chain reactions; DNA fingerprinting; Southern and northern blotting; In-situ hybridization;
RAPD; RFLP; Site-directed mutagenesis; Gene transfer technologies; Gene therapy.

Bioinformatics: Major bioinformatics resources (NCBI, EBI, ExPASy); Sequence and


structure databases; Sequence analysis (biomolecular sequence file formats, scoring
matrices, sequence alignment, phylogeny); Genomics and Proteomics (Large scale genome
sequencing strategies; Comparative genomics; Understanding DNA microarrays and
protein arrays); Molecular modeling and simulations (basic concepts including concept of
force fields).
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