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Therapy Worksheet Title of Article: Authors: Journal: Background

THERAPY WORKSHEET: are the results of this single preventive or terapheutic trial valid? What is the magnitude of the treatment effect? How precise is the estimate of treatment effect?

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Randi Kosim Siregar
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40 views

Therapy Worksheet Title of Article: Authors: Journal: Background

THERAPY WORKSHEET: are the results of this single preventive or terapheutic trial valid? What is the magnitude of the treatment effect? How precise is the estimate of treatment effect?

Uploaded by

Randi Kosim Siregar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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THERAPY WORKSHEET

Title of Article:
Authors :
Journal :
Background :


Objective :


Methods :

THERAPY WORKSHEET
Are the results of this single preventive or terapheutic trial valid?
Was the assignment of patients to
tretments randomized?

Was the randomization list concealed?
Was follow up of patients sufficialy
long and complete?

Were all the patients analyzed in the
groups to which they were randomized?

Were patients, clinicians, and study
personnel kept blind the treatment?

Were the groups treated equally, apart
from the experimental treatment?

Were the groups similar at the start of
the trial apart from the experimental
therapy?


Are the valid results of this randomized trial important?
What is the magnitude of the treatment
effect?

How precise is the estimate of
treatment effect?


SAMPLE CALCULATIONS
Occurence of diabetic
neuropathy at 5 years among
insulin-dependent diabetics
in DCCT trial
Relative Risk
Reduction
(RRR)
Absolute
Risk
Reduction
(ARR)
Number
Needed to
Treat (NNT
CER EER CER-EER
CER
CER-EER 1/ARR

95%CI
1,96




YOUR CALCULATIONS
Relative Risk
Reduction
(RRR)
Absolute Risk
Reduction
(ARR)
Number Need
to Treat
(NNT)
CER EER CER-EER
CER
CER-EER 1/ARR


Can You apply this valid, importance evidence about therapy in caring for
your patient?
Do this results apply to our patient?
Is our patient so different from those in
the study that is results cannot apply?

Is the treatment fessible in our setting?
What are our patients potential benefits and harms from the therapy?
Method I : f Risk of the outcome in our patient,
relative to patients in the trial.

Expressed as a decimal:

NNT/f= / =
(NNT for patients like ours)
Method II : 1/(PEER x RRR) Our patients expected rate if they
received the control treatment (PEER)
=
1/(PEER x RRR) = 1/ =
(NNT for patients like ours)
Are our patients value and preferences
satisfied by the regimen and its
concequences?

Do we and our patients have a clear
assesment of their values and
preferences?

Are they met by this regiment and its
concequences?

Additional Notes:

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