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Module 2 - Connective Tissue Cells

This document describes the cellular characteristics and roles of resident and wandering cells found in connective tissue. Resident cells such as fibroblasts, chondroblasts and osteoblasts synthesize proteins of the extracellular matrix. Wandering cells, including macrophages, mast cells, lymphocytes, and neutrophils, have roles in immune functions like phagocytosis, antigen presentation, and cytokine secretion. Fibroblasts synthesize collagen and elastin. Macrophages phagocytose foreign substances and present antigens. Lymphocytes and plasma cells are involved in immune responses.

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Sam Tagarda
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78 views

Module 2 - Connective Tissue Cells

This document describes the cellular characteristics and roles of resident and wandering cells found in connective tissue. Resident cells such as fibroblasts, chondroblasts and osteoblasts synthesize proteins of the extracellular matrix. Wandering cells, including macrophages, mast cells, lymphocytes, and neutrophils, have roles in immune functions like phagocytosis, antigen presentation, and cytokine secretion. Fibroblasts synthesize collagen and elastin. Macrophages phagocytose foreign substances and present antigens. Lymphocytes and plasma cells are involved in immune responses.

Uploaded by

Sam Tagarda
Copyright
© © All Rights Reserved
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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CONNECTIVE TISSUE:

Cellular Characteristics
and roles
Resident Cells Wandering/transient
Cells
Fibroblasts,
chondroblast,
osteoblast, odontoblast
Macrophages
Adipose cells
Mast cells
Undifferentiated
mesenchymal cells
Lymphocytes
Plasma Cells
Neutrophils
Eosinophils
Basophils
Monocytes

Fibroblasts

Synthesize collagen,
elastin, GAG,
proteoglycans,
multiadhesive
glycoproteins
Involved in
production of growth
factors
Macrophages

Secretion of cytokines &
other molecules
Phagocytosis of foreign
substances & bacteria
Antigen processing and
presentation to other cells
Constitute the MPS
Characterized by irregular
surface w/ pleats,
protrusions, indentations,
a well developed golgi
complex, many lysosomes,
a prominent RER
Adipose Cells

Specialized for
storage of neutral
fats or for the
production of heat
A.k.a. fat cells
Mast Cells and basophils

Oval to round
Cytoplasm filled
w/ basophilic
secretory granules
Small, spherical
nucleus centrally
located
Liberation of
pharmacologically
active molecules
(eg, histamine,
heparin)
Pericytes

A.k.a.
adventitial/perivascular
cells
Found around capillaries
and venules
Surrounded by basal
lamina material
Typically wrapped, at
least partially, around
capillary
Nucleus takes on a shape
similar to endothelial cells
(flattened but curved)
Lymphocyte

Production of
immunocompetent
cells
Have a thin rim of
cytoplasm
surrounding a
deeply staining,
heterochromatic
nucleus
Smallest of the
free cells in the CT
Most numerous in
lamina propria of
the GI tracts
Plasma Cells

Production of antibodies
Relatively large, ovoid,
with a considerable
amount of cytoplasm
Cytoplasm -> basophilic
due to extensive rER
Nucleus spherical &
typically
offset/eccentrically
positioned, exhibit large
clumps of peripheral
heterochromatin
alternating w/ clear areas
of euchromatin
Neutrophils

Phagocytosis of
foreign substances,
bacteria
Most common
WBC
Larger than RBCs
Multilobed
nucleus

Eosinophils

Participation in
allergic &
vasoactive
reactions
Modulation of
mast cell activities
& the
inflammatory
process
Nuclei typically
bilobed
Monocytes

Precursors of the
cells of the MPS
Largest of the
WBCs
Travel from bone
marrow to body
tissues, where they
differentiate into
various phagocytes
of the MPS

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