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FRUSEMIDE

Frusemide is a strong diuretic used to treat edema caused by heart failure, liver or kidney disease, and hypertension. It works by increasing urine output, which reduces blood pressure by lowering fluid volume. Common side effects include dizziness, weakness, and electrolyte imbalances. Special precautions are needed in pregnancy, children, the elderly, and with concurrent use of other drugs due to interaction risks.

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krishna chandrakani
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446 views

FRUSEMIDE

Frusemide is a strong diuretic used to treat edema caused by heart failure, liver or kidney disease, and hypertension. It works by increasing urine output, which reduces blood pressure by lowering fluid volume. Common side effects include dizziness, weakness, and electrolyte imbalances. Special precautions are needed in pregnancy, children, the elderly, and with concurrent use of other drugs due to interaction risks.

Uploaded by

krishna chandrakani
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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FRUSEMIDE

It is a strong diuretic but lacks specific anti-hypertensive


action. ( has no direct effect on resistance vessels).
Thus anti hypertensive efficacy is directly related to
diuretic potency.
Fall in BP is due only to reduced plasma extracellular fluid
volume.
INDICATIONS :
Oedema in congestive heart failure,
hepatic and renal disease.
Cerebral oedema,
forced diuresis for poisoning,
toxaemia of pregnancy.
Hypertension and hypertensive crisis.
DOSAGE :
ADULT : 20-80 mg as a single dose. if satisfactory
results are not obtained than 20-40 mg after 6 hrs.
INFANT & CHILDREN : 2mg /kg body wt increased
by 1-2 mg/kg 6-8 hrs after the previous dose.
MAX : 40 mg /day.

CONTRA INDICATIONS :
Renal failure with anuria,
potassium deficiency ( i.e. malnutrition, diarrhoea).
Hypersensitivity to frusemide & sulphonamides,
Hypokalaemia
Hyponatraemia
Hepatic coma
Hypovolaemia with/without hypotension.
SPECIAL PRECAUTIONS :
Electrolyte imbalance (monitor serum electrolyte)
Paediatrics : can be used safely.
Pregnancy : Contraindicated.
Lactation : Used if clearly indicated.
Elderly : Increased risk of side effects. Dose to be reduced.
SIDE EFFECTS :
Vertigo.
Visual impairment.
Sodium deficiency may cause orthostatic hypotension.
Calf muscle cramps.
Anorexia.
Weakness.
Dizzinesss.
Drowsiness.
Vomiting.
hyperuricaemia reduced glucose tolerance.
Deafness.
DRUG INTERACTIONS :
Aminoglycoside antibiotics may enhance the risk of
deafness, potentiates anti hypertensives, causes litihum
toxicity in those receiving both drugs. With cotrimoxazole
produces thrombocytopenia. NSAIDs diminish the diuretic
effects.

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