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Differentiate A Dihydropyridine Receptor From From Ryanodine Receptor - Migs Valdez

The ryanodine receptor is a ligand-gated calcium release channel located in the membrane of terminal cisternae in muscle cells. It is responsible for increasing intracellular calcium levels in response to action potentials. The dihydropyridine receptor is a voltage-gated calcium channel found in excitable cell membranes. It is activated by depolarization and allows extracellular calcium influx to produce an action potential in the t-tubule, which then signals the ryanodine receptor to release calcium from the sarcoplasmic reticulum.

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Michael Urrutia
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97 views5 pages

Differentiate A Dihydropyridine Receptor From From Ryanodine Receptor - Migs Valdez

The ryanodine receptor is a ligand-gated calcium release channel located in the membrane of terminal cisternae in muscle cells. It is responsible for increasing intracellular calcium levels in response to action potentials. The dihydropyridine receptor is a voltage-gated calcium channel found in excitable cell membranes. It is activated by depolarization and allows extracellular calcium influx to produce an action potential in the t-tubule, which then signals the ryanodine receptor to release calcium from the sarcoplasmic reticulum.

Uploaded by

Michael Urrutia
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Differentiate a dihydropyridine

receptor from from ryanodine


receptor
Miguel Angelo E. Valdez
RYANODINE RECEPTOR (RYR)

Ligand gated ion channel
Carelease channels in the membrane of the
terminal cisternae that are responsible for
elevation in the intracellular [Ca] in the
respnonse to the AP.
Large Protein
Mostly appears in the Myoplasm and spans
the gap between the terminal cisternae and
the T- tubule.
Dihydropyridine Receptor (DHPR)
L type voltage- gated Ca channel
High Volatage Activated
Activated via Depolarization

Found in the membrane of excitable cells
Responsible for the influx of Extracellular
Calcium to produce an AP in the T- Tubule that
will induce relation of Ca from the SR (RYR)

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