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Introduction To Pathology: Range of Services: Histopathology

This document provides an overview of the range of services in pathology, including histopathology of biopsies and resections to examine tissues for cancer and other diseases, cytopathology of fluid samples and scrapings, immunohistopathology using antibody markers to identify cell types and tumors, and molecular pathology to diagnose cancers and predict treatment responses. Challenges include inadequate or incorrect sampling and not considering the proper clinical context when examining morphology.

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Wilson Ong Ying Fa
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24 views

Introduction To Pathology: Range of Services: Histopathology

This document provides an overview of the range of services in pathology, including histopathology of biopsies and resections to examine tissues for cancer and other diseases, cytopathology of fluid samples and scrapings, immunohistopathology using antibody markers to identify cell types and tumors, and molecular pathology to diagnose cancers and predict treatment responses. Challenges include inadequate or incorrect sampling and not considering the proper clinical context when examining morphology.

Uploaded by

Wilson Ong Ying Fa
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Introduction to pathology:

Range of Services:
Histopathology:

Small biopsies (endoscopic)


o Gastric, colonic, skin punch biopsy
Simple excision biopsies:
o Simple excision of lesion, usually small and/or benign
Wide local excision biopsies:
o Excision of lesion with wide margins. Eg. Breast ca
Complex resection specimens
o Cancer
o Multi-organs (en-bloc resection)
o Surgical margins, local invasion, lymph nodes important (i.e. pathological
staging criteria
Problems:
Inadequate sampling, wrong sampling
Wrong clinical context. (morphology and mimickers)

Cytopathology

Non-gynecologic
o FNAC (thyroid/breast)
? Cellular, multiple cell population
o Fluids (exfoiative cytology)
o Scrapings
Gynecologic:
o Cervical smears
Liquid based
Conventional

Immunohistopathology: (monoclonal or polyclonal antibodies)

Immunoperoxidase (use of antigenic markers)


o Monotonous proliferation of lymphoid cells lymphoma (CD3Tcell,
CD20Bcell)
o Typing of tumours
Immunofluorescence
o IgG GN (membranous GN secondary to lupus nephritis) epithelial deposits
Chromogen In situ Hybridization (CISH)

Molecular Pathology

Diagnosis of tumours:
o Lymphoma,soft tissues tumour
o Predicting response to therapy

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