Pathology Lecture Notes
Pathology Lecture Notes
9.30.14
Websitepassword:genpath
IseeAsians.
10.2.14
Ibecameapartofaccordionclub.
Doyouplaytheaccordion?
No.
10.3.14
Wemakedoctors,notmetaphysicallunatics.
Plasmallema:bilipidlayer.Proteinsmakeup40%ofit.Functions:cellisabagof
organellesandthemembraneprotectsit.(HIVvirusdrillsholesintoacellmembrane
helperTcellsakaCd4+cells).Poliovirusdoesthistonervecells.Cellmembranemust
bemadeporoustoallowpassageofamacromolecule.Ex:hormonesaremadeinthecell
butcanbesecretedtotravelthroughthebloodstream.Anotherexisdigestiveenzymes
thepancreasendocrinehormonessecretedintotheblood,andthedigestiveenzymesof
theexocrineportionwillbesecretedviathebileduct.
Myastheniagravis:type2sensitivity.AcHreceptorisdestroyedorblocked(canbe
treatments).
Ifthecellisinjured,whathappensenergywisetokeepthesodiumpumprunning?
Initially,theNAconcentrationofthecellwillincrease,thewaterwilldiffusein,andthe
cellenlarges(hydropicswelling).Consideredareversiblechange.
Mitochondrion:energyproduction.Doublemembrane.Outermembraneconnectedtothe
ER.Passeddownmaternally.
Ribosomestructure
S=svedburgunit
Lysosomalstoragediseases
Needtoknowforboards:
GauchersDisease
TaeSachsDisease
NiemannPick
VonGierke
Phenylketonuria
*Kowpyknosis,karyorrhexis,karyolysisforboards.