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Neurons and Conductance-Based Models

This document discusses neurons and conductance-based models. It covers the biological background of membrane potential and ion channels. It then discusses synaptic transmission and different receptor types. It introduces conductance-based models and provides links to resources on the Hodgkin-Huxley model, the minimal mechanism underlying action potentials, and Hodgkin-Huxley equations. The document lists simulators that can be used to simulate compartmental models including Neuron and GENESIS.

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jsebas635
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42 views16 pages

Neurons and Conductance-Based Models

This document discusses neurons and conductance-based models. It covers the biological background of membrane potential and ion channels. It then discusses synaptic transmission and different receptor types. It introduces conductance-based models and provides links to resources on the Hodgkin-Huxley model, the minimal mechanism underlying action potentials, and Hodgkin-Huxley equations. The document lists simulators that can be used to simulate compartmental models including Neuron and GENESIS.

Uploaded by

jsebas635
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Neurons and conductancebased models

Biological background

Membrane potential

http://icwww.epfl.ch/~gerstner/SPNM/node13.html

Ion channels

Glu receptors

2nd messenger mechanism

Synapse

Non-NMDA: AMPA, GABA

Conductance-based models
http://dev.physicslab.org/Document.aspx?doctype=3&filename=DCcircuits_KirchhoffCapacitors.xml

http://www.scholarpedia.org/article/Conductancebased_models

MATLAB program

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Hodgkin-Huxley model

Typical form of an action potential; redrawn from an


oscilloscope picture from Hodgkin and Huxley (1939).

Alan Hodgkin and Andrew Huxley


The Nobel Prize in Physiology or Medicine 1963 (with John Eccles)

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The minimal mechanism

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Hodgkin-Huxley equations and simulation

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Compartmental models

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Simulators
http://neuron.yale.edu/neuron/courses

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Simulator (2)
http://www.genesis-sim.org/GENESIS/
They stopped in 2006

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