Article: 2670: Comorbid Bipolar Disorder and Borderline Personality Disorder and History of Suicide Attempts
Article: 2670: Comorbid Bipolar Disorder and Borderline Personality Disorder and History of Suicide Attempts
Background: Both bipolar disorder and borderline personality disorder are associated with elevated rates of completed and
attempted suicide. No studies have examined whether there is an additive risk for suicidal behavior in patients diagnosed with
both disorders. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS)
project we tested the hypothesis that patients diagnosed with both bipolar disorder and borderline personality disorder would
have a higher rate of suicide attempts than patients with either diagnosis alone.
Methods: Three thousand four hundred and sixty-five psychiatric outpatients were interviewed with semi-structured interviews.
Results: The suicide attempt rate in both the bipolar disorder and borderline personality disorder groups was significantly
higher than the rate in patients without either of these disorders. Compared to the bipolar patients without borderline
personality disorder, the patients diagnosed with both bipolar and borderline personality disorder were significantly more likely
to have made a prior suicide attempt (58.0% vs. 28.9%, p< .001) and to have made multiple suicide attempts (33.3% vs.
16.5%, p< .01). The patients with borderline personality disorder and bipolar disorder were nonsignificantly more likely than the
borderline patients without bipolar disorder to have made a prior suicide attempt (58.0% vs. 46.7%, p=n.s.) and to have made
multiple suicide attempts (33.3% vs. 24.2%, p=n.s.)
Conclusions: While bipolar disorder and borderline personality disorder are each risk factors for suicidal behavior, the cooccurrence of these disorders confers an additive risk.