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Dopamine

Dopamine is a catecholamine found in neurons of the central and peripheral nervous systems. It is formed from the decarboxylation of DOPA and is a precursor of adrenaline and noradrenaline. Dopamine hydrochloride is administered intravenously and takes effect within five minutes, lasting less than ten minutes, and can be used to treat massive phenobarbital overdose through dopamine diuresis. Dopamine increases urine output by activating DA1 receptors in the kidney, which causes renal vasodilation and increased renal blood flow and GFR.

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Baby Lyn Ann Tanalgo
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242 views

Dopamine

Dopamine is a catecholamine found in neurons of the central and peripheral nervous systems. It is formed from the decarboxylation of DOPA and is a precursor of adrenaline and noradrenaline. Dopamine hydrochloride is administered intravenously and takes effect within five minutes, lasting less than ten minutes, and can be used to treat massive phenobarbital overdose through dopamine diuresis. Dopamine increases urine output by activating DA1 receptors in the kidney, which causes renal vasodilation and increased renal blood flow and GFR.

Uploaded by

Baby Lyn Ann Tanalgo
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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DOPAMINE:

DESCRIPTION
Dopamine is a catecholamine found in
neurons of both the central and peripheral
nervous system. It is a monoamine and is
a precursor of adrenaline and
noradrenaline. It is formed from the
decarboxylation from DOPA

DOPAMINE:
PHARMACOKINETICS
Dopamine in the form of
dopamine hydrochloride is
usually administered by
intravenous infusion
Onset of action occurs within
five minutes of intravenous
administration and with its
plasma half-life of about two
minutes, the duration of
action is less than ten

DOPAMINE:
PHARMACOKINETICS
Phenobarbital intoxication can usually be
treated by supportive measures and
administration of large amounts of fluid
and diuretics to promote renal excretion
of the drug.
Treatment of massive phenobarbital
overdose is possible with dopamine
diuresis

DOPAMINE
MECHANISMS IN
INCREASING URINE
OUTPUT

Activation of -1
receptors in the
heart

DOPAMINE

Activation of DA-1
receptors in the
kidney

Receptor

ResultofReceptor Contributionto
Activation
TherapeuticEffect

DA1

The renal
vasodilation will
improve renal blood
flow and increase
GFR.
Produces a positive
inotropic effect.

beta1
alpha1 and alpha2

This will increase


urine output and
decrease fluid
retention and
edema.
Increase in cardiac
output. This is
beneficial in CHF.
Vasoconstriction is This will counteract
not a desired effect. the beneficial effects
on renal blood flow.
In addition,
increases in TPR
will negatively affect
cardiac output.

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