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Rev Exam2

This document provides example problems covering four major reaction engineering areas: non-isothermal reactors, biological reactors, ligand/receptor binding kinetics, and surface reactions/catalysis kinetics. The first example problem describes an irreversible liquid phase reaction occurring in a continuous stirred-tank reactor (CSTR). It provides kinetic parameters and asks to calculate conversion and heat duty under various operating conditions including isothermal, adiabatic, and non-adiabatic scenarios. The second example problem considers a Monod growth reaction in a continuous perfectly mixed bioreactor, asking to determine the dilution rate for maximum productivity and number of tanks required to reduce substrate concentration below a threshold.

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60 views

Rev Exam2

This document provides example problems covering four major reaction engineering areas: non-isothermal reactors, biological reactors, ligand/receptor binding kinetics, and surface reactions/catalysis kinetics. The first example problem describes an irreversible liquid phase reaction occurring in a continuous stirred-tank reactor (CSTR). It provides kinetic parameters and asks to calculate conversion and heat duty under various operating conditions including isothermal, adiabatic, and non-adiabatic scenarios. The second example problem considers a Monod growth reaction in a continuous perfectly mixed bioreactor, asking to determine the dilution rate for maximum productivity and number of tanks required to reduce substrate concentration below a threshold.

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HungDo
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Four major areas (: covered in the following example problems):

Non-isothermal reactors ()
Biological reactors ()
Ligand/receptor binding kinetics
Surface reactions/catalysis kinetics
Go over the first problem in PS7 to review the ligand/receptor binding kinetics and
the first problem in PS8 to review the surface reactions/catalysis kinetics.
Problem 1.
The irreversible liquid phase reaction A R + S is carried out in a CSTR. The reaction is
first order in A. The feed stream is available at a temperature of 298 K.
-4 -1

k = 1.7 x 10 s at 298 K.
3

Ea = 41.87 x 10 kJ/kmol

HR(298) = -167.5 x 10 kJ/kmol


3

CA0 = 2.0 kmol/m (Feed is pure A)


3

V = 0.5 m

= 1050 kg/m
Cp = 4.19 kJ/kg/K
These values can be considered to be constant over the used interval of concentration and
temperature. The CSTR is made of carbon steel and weighs 800 kg.
Cp,steel = 502.4 J/kg/K
Calculate:
a) Conversion and heat duty for an isothermal reactor operating at 298 K.
b) Conversion and reactor temperature for an adiabatic reactor with inlet temperature
of 298 K.
c) Conversion and preheating temperature for an adiabatic reactor with a reactor
temperature of 363 K.
d) Conversion and heat duty if the reactor is operated non-adiabatically without
preheating and at a temperature of 363 K.
Problem 2.

Consider an organism which follows Monod equation of growth with max = 0.5 h-1 and Ks = 2 g/L.
a)
b)

In a continuous perfectly mixed vessel at steady state with no cell death, if the substrate
concentration in the feed is Sfeed = 50 g/L, the yield Y = 1 (g cells / g substrate), what
dilution rate D gives the maximum volumetric productivity?
For the same dilution rate as part (a) using tanks of the same size in series, how many
vessels will be required to reduce the substrate concentration to less than 1 g/L?

Cite as: William Green, Jr., and K. Dane Wittrup, course materials for 10.37 Chemical and Biological Reaction Engineering,
Spring 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY].

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