Institute of Child Health and

Great Ormond Street Hospital for Children NHS Trus

Research Review 2002

Building on success
68

Awards, Honours and Prizes 2001

Staff from the ICH and GOSH received national and internation
recognition for their research achievements in 2002
Dr John Achermann received the Young outcomes at the WHO Global Consultation Science. She was also apse*"
Investigator Award from the European Society in Child and Adolescent Health and Children's Nursing Researcr
of Paediatric Endocrinology & Metabolism. He Development in Stockholm, Sweden.
was an invited speaker at the Brazilian Society • Nutritional and neonatal outcome in Mr Robert Garrett-Cox
of Endocrinology & Metabolism (Brasilia), developing countries at a USAID/Wellcome Peter Paul Rickham Przf al I
Society for Endocrinology (London), Trust meeting in Oxford on nutrition as British Association of Paec-at"':
IUPAC/SCOPE congress on endocrine a preventative strategy against adverse meeting for his presentation 3~
disruption (Yokohama), and Henning Anderson pregnancy outcomes in developing countries. Glutamine: a novel the : :
Workshop (Copenhagen). • Integrated models of community-based sepsis? Supervised by Sirrxy i
perinatal and newborn care: what do we Agostino Pierro.
Dr Paul Aurora received the European do now? at the 16th International Biennial
Respiratory Society, Young Investigator of Paediatric conference in Karachi, Pakistan. Dr David Goldblatt ga 5 a'
the Year award. This was in recognition of • The poor mother and infant: Ethical issues on Immune memory to '.-e : "-?-"
published work in the field of lung in international mother and child health, at at the Third Internatic"
transplantation. the Ethical Society, London. Pneumococci and Pneumococce
Alaska (May 2002). He ga\e :.•••:
Professor Albert Aynsley-Green was made Mr Peter Cuckow received a Royal College lectures at the Australasian C
the 12th Queen Elizabeth the Queen Mother of Surgeons pump-priming award for The and Allergy Society Annual K/
Fellow by the trustees of the Nuffield Trust. Urodynamic Consequences of Bladder Outflow and lectured on Conjugate vaca
Obstruction on the Developing Foetal Bladder. National Centre for Immunisalia
Professor Martin Barrett was awarded and Surveillance of Vaccine
the James Spence Medal for outstanding Dr Jena Derakhani Hamdani received a Disease in Sydney, the State dt
contributions to the advancement or clarification Young Scientist award for her presentation to Department of Health and Ageing. I
of paediatric knowledge at the Royal College the Mini Symposium on Nutrition and brain and the Murdoch Rese; :
of Paediatrics and Child Health 2002 function and development in September 2002. Royal Children's Hospital M&tnu
Spring meeting. 2002). Dr Goldblatt also ga.e -
Professor Carol Dezateux has been on vaccines at the Inaugura -.ere:
Dr Maria Bitner-Glindzicz was invited appointed Chair of the MRC Autism Research Clinical Immunology Seminar in Lyo
to speak at the Danish Medical Society Strategy Initiative. She has become a member October 2002, and at the Cor
in Copenhagen, the Irish Society of of the Cancer Research UK Population and Europeenne de Pediatrie &~~ ~
Audiology in Cork and the British Society Behavioural Sciences committee. Board of Pediatrics Annual Meetre
of Audiological Physicians. Brussels (December 2002).
Dr Simon Eaton was awarded the
Dr Julie Carter received the runner-up prize 2002 Sir David Cuthbertson Medal, given Dr Ian Hann was invited to}
for the Royal Institution of Great Britain, Best to investigators under the age of 40 for National Cancer Research InstfcJ
2002 Science Graduate. their contribution to nutritional research. haematology/oncology studies tx

Professor Andrew Costello gave a Dr Simone Fiore, MRC Training Fellow, Professor David Hatch v. as =
keynote lecture entitled Strategies to reduce received an award from the Foetal Medicine chairman of the CMC's Continurc
neonatal mortality at the International Society Foundation for her spoken presentation on Professional Development Boara
of Tropical Paediatrics meeting, Ankara, in foetal growth in HIV infected mothers. awarded the John Snow medal b
September 2002. He was also invited to give Association of Anaesthetises cf Gr=
the following lectures: Professor Linda Franck has been elected a and Ireland, and was appor'-:
• Strategies to improve neonatal health Fellow of the European Academy of Nursing of the Neonatal Society.
Grants and Donations 2002
We are grateful to the organisations listed below for their generosity.
The work of the ICH also depends on the ongoing support of a
number of organisations acknowledged at the end of this list.
Action Research phamacokinetics of recombinant anti- British Council For The Prevention
Professor A Pierro, Dr S Eaton, haemophilic factor manufactured and Of Blindness
Professor C Dezateux, Dr A Wade, formulated without added human or Dr R Gilbert for a national surveillance
Dr HKF van Saene, Dr N Klein, animal proteins. study of congenital toxoplasmosis
Dr AP Reynolds, Professor DA Lloyd Dr P Lister and Dr M Peters for the
and Professor L Spitz an award to investigation of the role of the protein C British Educational Communications
support the Surgical Infants Glutamine pathway in necrotising enterocolitis of and Technology Agency
Nutrition Trial: Glutamine supplementation critically ill neonates. Mr C Clayton, Ms N Jolleff,
in parenteral nutrition of surgical Ms K Price, Ms C Davidson (Cenmac)
newborn infants. Biotechnology and Biological Sciences and Mr M Dale-Emberton (Charlton Schoou
Professor P Scambler, Dr N Shah, Research Council for an AIDS communication project.
Professor P Milla, Dr A Philips Dr M Hubank an award to investigate a
(Royal Free Hospital) and Dr R Thompson new approach to the biological interpretation British Heart Foundation
(Kings College Hospital), to study the isolation and analysis of Gene Array Time Series Data. Professor R Anderson, Dr D Henderson
of the gene defect causing microvillous atrophy. Dr J Sowden an award to study tbx20 and Professor N Brown (St George's
Professor R Winter an award to develop orthologues and the generation of Hospital Medical School), for a programme
a phenotype database to discover morphological diversity. of research to study fate and function of exr=
malformation genes. Dr A Stoker to characterise the signalling cardiac cell populations in heart developme"
mechanisms of receptor tyrosine phosphates and malformation.
Alistair Berkley Charitable Trust CRYP-alpha. Professor R Anderson, Mr M Kanani,
Dr S Hartley for community based Mr M Elliot, Ms M Jahangir (St George's
rehabilitation in Uganda: monitoring Biocontrol Ltd. Medical Trust) and Professor T Ebels
and evaluating practices with a view Dr J Soothill for biological control of (Groningen University), to investigate
to developing suitable indicators. infections and infestations specified as the surgical management of the left
potential areas for investigation, and atrioventricular valve in atrioventricular
Arthritis Research Campaign the commercial development thereof. septal defects.
Dr K Gustafsson and Professor A Thrasher Dr B Brar and Professor D Latchman
to fund a PhD Studentship to study the role of Birth Defects Foundation to investigate the protective and hypertr
dendritic cells in the induction of immunity and Professor R Winter and Dr N Prescott effects of urocortin.
tolerance to collagen II. an award for an investigation of the role of Professor C Dezateux, Dr R Knowles
Professor M Londei to study modulation clefting syndrome genes in nonsyndromic and Dr C Wren (Freeman Hospital, Newcastle
of chronic arthritis via the generation of Tr1 cleft lip and palate. upon-Tyne), for a national cohort study into
cells and the comparison with the activity of the outcome at school age of congenital
B regulatory cells. Breast Cancer Campaign heart disease.
Dr V Budhram-Mahadeo to research Brn-3b Professor D Latchman to investigate
Association for International transcription factor in breast tumourgenesis- the role of transcriptional co-factors in
Cancer Research mechanism of regulating cellular growth. cardiac hypertrophy.
Dr V Budhram-Mahadeo to study the Professor D Latchman, Dr A Stephanou
mechanisms mediating over-expression British Consulate - General and Professor D Yellon (UCL), an aware I:
of the Brn-3b transcription factor in Professor T Cole, Professor H Pan and investigate the role of the STAT-1 transcriptic'
breast tumours. Professor Y Yang (Institute of Child Health factor in ischaemia/reperfusion injury in the
of Shanghai), to monitor and prevent intact heart.
Baxter Health Care malnutrition and obesity in childhood.
Professor A Pierro, Dr S Eaton, Professor D Latchman and
Dr N Klein, Dr K Bethune, Professor British Council Dr A Stephanou, an award to investigate IN
P Milla and Dr S Hill to study the effect of Professor J Stocks, Dr J Pillow and regulation of the capases pathway in cardiac
different intravenous fat emulsions on fat Dr G Hulskamp for the implementation of cells and the intact heart in response to
I on, peroxidation and immune function low frequency forced oscillation technique in ischaemia/reperfusion.
n infants and children on parenteral nutrition. the neonatal intensive care unit. Dr A Stephanou, Dr D Yellon (UCL) and
Dr R Liesner an award to test the Dr L Wedderburn for a collaborative Professor D Latchman to investigate the
r~ . : ~~~ nogenicity, safety and workshop with representatives from The role of the C-terminal of STAT-1 in ischae~ c
Netherlands, held at the ICH. reperfusion injury in cardiac cells.
B Evans (City University), for equipment to Medical Research Council (MRC) NHS Executive
study an objective measure of the benefit Professor A Copp, Dr D Gerrelli and Professor L Spitz, Dr S Reilly, Dr M
afforded by precision tinted spectacles in Ms A Murray four awards for research Lawson, Dr H McConachie, Dr H Cass,
subjects with dyslexia. into Consolidation of the MRC / Wellcome Dr L Carr, Dr R Hastings and Ms G Craig
Trust Human Developmental Biology additional funding for medical and psychosocia!
Janssen-Cilag Resource. effects of gastrostomy feeding interventions for
Dr H Cross for an open naturalistic Mr D Jenkins, Professor A Woolf, Dr S children with cerebral palsy and their families.
individual dose optimisation trial assessing Feather, Mr S Welham and Dr L McCarthy
tolerability and efficacy in recently diagnosed for genetics and developmental biology of Nuffield Foundation
patients with epilepsy. vesicouretic reflux (VUR). Dr D Glaser, Dr G Hodges and Ms V Prior,
Professor J Harper with Professor WOCM for a child care consultation team follow-up study.
Jeans For Genes Cookson (Oxford), received funding for family Dr L Rees and Dr S Waller to investigate the
Professor J Stocks, Dr J Pillow and Dr G recruitment to study the molecular genetics optimum range of circulating parathyroid hormone
Hulskamp for the development and validation of atopic dermatitis in children with chronic renal failure that maximises
of new lung function equipment in the intensive Professor A Lucas for research into growth and minimises renal osteodystrophy.
care unit. paediatric nutrition.
Dr D Muller to study the urinary metabolites Olivia Hodson Fellowship
Jerome Lejeune Foundation of vitamin E. Dr F Gibson received funding to support
Dr D Muller, Professor S Grantham- Dr P Riley to investigate the role of Hand"! in a Children's Cancer Nursing Fellow at GOSH.
McGregor, Dr C Ani and Dr R Moy (ICH, cell movement and migration during cardiac
University of Birmingham), a renewal of funding morphogenesis. Orphan Europe
for a randomised controlled trial of the effects Mrs B Lewin, Mrs M Rogers, Dr B Gasper
of antioxidant supplementation on the mental Mount Everest Foundation and Dr E Gerritsen (St Clara Hospital,
development, growth and health of children Professor Monty Mythen, for the development Rotterdam), for a study to look at psychological
with Down's syndrome. of a high altitude medicine and physiology sequelae of adenine deaminase deficiency
Dr D Muller, Dr S Logan, Dr R Gilbert, education website (space and extreme following bone marrow transplant.
Professor T Cole, Professor Grantham environment physiology) Dr W Van't Hoff and Ms Collin for the
McGregor, Dr C Ani and Dr J Ellis an award development of a national registry of
for a randomised controlled trial of the effects of MRC/Wellcome Trust cystinosis patients.
antioxidant and folic acid supplementation on Professor A Copp, Dr Gerrelli,
the mental development, growth and health of Dr A Murray and Professor C Rodeck (UCL), Parkinson's Disease Society
children with Down's Syndrome. for consolidation of a Human Developmental Professor D Latchman for analysis of
Biology Resource. the role of parkin in familial and non-familial
Kidney Research Aid Fund Parkinson's disease.
Mr P Ransley for a clinical trial of deflux for National Alliance for Autism Research
endoscopic correction of severe vesicoureteric Professor D Skuse and Professor E Lander, Pfizer
reflux and the effects on improving bladder to identify a genetic cause of male susceptibility Dr A Jaffe, Dr K Yoshimura
function outcome. to autism. (Jikei University, Tokyo) and Professor E Alton
An annual donation to Professor A Woolf (Imperial College), an award for assessment
and Dr M Godley for a trial of endoscopic National Alliance for Research on of CFTR function in vivo patients with diffuse
treatment of vesicouretic reflux in infants. Schizophrenia and Depression pan-bronchiolitis.
Professor P Scambler and
Leukaemia Research Fund Dr S Sivagnanasundaram for the Philip Ullman Trust
Dr W Qasim an award for trie development identification and evaluation of epistatic Dr S Eaton and Professor A Pierro an award
of T cell therapies to improve outcomes in interactions underlying prepulse inhibition in for an isotope ratio mass spectrometer
allergenic bone marrow transplantation for mouse hybrids: a model for schizophrenia.
haematological malignancies. PPP Foundation
National Kidney Research Fund Mr D South for his role as project manager of
London Regional NHS Trust Dr L Rees to investigate the optimum the Virtual Children's Hospital in collaboration
Dr C Dezateux ana Dr S Ofiver (Institute range of circulating parathyroid hormone, in with the University of Sheffield.
of Education), to explore the mpfcaDons for children with chronic renal failure that
parents and professionals of earner scrsenrc maximises growth and minimises renal Primary Immunodeficiency Association
for cystic fibrosis and sooe eel tfeuRJas ostoedystrophy. Dr H B Caspar, Dr P Veys and Dr A Thrasher
Dr P Winyard an award to characterise the for the analysis of immune function following low
London School Of Hygiene and T30H model of spontaneous urinary tract intensity conditioning stem cell transplantation
Tropical Medicine - - - - --" for severe congenital immunodeficiency.
Dr W Cubitt, Dr R Hayes _£-~ Professor A Woolf for research into Dr HB Caspar and Dr A Thrasher, an award
Dr D Ross (LSH~ angiapoietins and kidney vascular development. for the development of in vitro and in vivo
Kwa Vijana Project. rofessor Woolf received further funding (co- models of gene therapy for X-linked lympho-
Dr H Cross, for the open nafeiafsfc nr>. appfcant Dr P Wnyard) for a NKRF Studentship. proliferative syndrome.
dose optimisation tna =s=e=s,~c --•?-=£.•-. Dr A Thrasher received funding to investigate
and efficacy in recently diagnosed uafafe i Society gene therapy for Wiskott-Aldrich syndrome and
epilepsy who are treatment nawe • • glade (pression of an award for the clinical trial of gene therapy
one anti-epileptic drug B-MYB to tfie neuroectoderm. for X-SCID.