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Dengue Pathophysiology

Predisposing factors for dengue include living in tropical geographical areas with decreased immune systems. Mosquitoes infected with dengue virus bite hosts and inject the virus, which incubates in the blood for 3-14 days before rapidly disseminating throughout the bloodstream. The virus stimulates white blood cells like lymphocytes, monocytes, and neutrophils to produce antibodies and phagocytose the viral antigens within cells, where the virus replicates until it is recognized and causes the release of cytokines and vasoactive agents that stimulate further immune response and lead to dengue.

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Rafael Miguel Alon Protacio
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1K views

Dengue Pathophysiology

Predisposing factors for dengue include living in tropical geographical areas with decreased immune systems. Mosquitoes infected with dengue virus bite hosts and inject the virus, which incubates in the blood for 3-14 days before rapidly disseminating throughout the bloodstream. The virus stimulates white blood cells like lymphocytes, monocytes, and neutrophils to produce antibodies and phagocytose the viral antigens within cells, where the virus replicates until it is recognized and causes the release of cytokines and vasoactive agents that stimulate further immune response and lead to dengue.

Uploaded by

Rafael Miguel Alon Protacio
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC or read online on Scribd
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PATHOPHYSIOLOGY

Precipitating Factors:
Predisposing Factor: - Environmental Condition
- Geographical Area (Tropical) - Decreased Immune System
- Presence of mosquitoes carrying dengue virus

Aedes aegypti bites the host, injecting the virus

Virus incubates in the circulation for 3-14 days

Virus rapidly disseminates into blood

Stimulation of the WBC which includes B lymphocytes which


produces and secretes Ig, monocytes/macrophages and neutrophils

Antibodies attach to the viral antigens, and then macrophages perform phagocytosis
within the cells and dengue virus replicate in the cells

Recognition of dengue viral antigen on monocyte

Release of cytokines which consist of vasoactive


agents such as interleukins, tumor necrosis Entry to bone
Entry to spleen
factor, urokinase, and platelet activating factor marrow
which stimulate WBCs and pyrogen release

DENGUE

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