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Aliphatic and Aromatic Flowchart

The document describes a series of chemical reactions involving aromatic compounds. Key steps include: (1) bromination of an aromatic compound using bromine water, (2) acetylation of the brominated product using acetyl chloride, and (3) nitration, methylation, or halogenation of the acetylated product under various reaction conditions. The multi-step synthesis allows for the installation of different functional groups on the aromatic ring.

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0% found this document useful (0 votes)
813 views

Aliphatic and Aromatic Flowchart

The document describes a series of chemical reactions involving aromatic compounds. Key steps include: (1) bromination of an aromatic compound using bromine water, (2) acetylation of the brominated product using acetyl chloride, and (3) nitration, methylation, or halogenation of the acetylated product under various reaction conditions. The multi-step synthesis allows for the installation of different functional groups on the aromatic ring.

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Aromatic Series OH O

Br Br C
O

Br2 (aq) (i) NaOH


Br COCH3
(ii) COCl

O OH
OH−
NH2 NO2 conc CH3COCl / AlCl3
Sn, c HCl HNO3/H2SO4

purple neutral FeCl3 suitable 55oC


coloration conditions Cl2 or Br2 / AlCl3
CH3Br /AlCl3
CONH2 COCl X

COOH KMnO4, dil CH3


c NH3 PCl5
H2SO4
heat
Cl2 or Br2 / AlCl3
CH3OH CH3Br
Cl2
/AlCl3 CH3
uv light
COOCH3
CH3
C H 2O H C H 2C l
aq KOH X

heat CH3 and


Cl2 and CH3
uv light CH3
CHO C H C l2 X
aq KOH
CH3
heat

Cl2
uv light
COOH C C l3
aq KOH
heat

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