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Drug Study

This document summarizes information about Penicillin G Benzathine/Penicillin G Procaine, including its trade names, pharmacology, pharmacokinetics, indications and usage, contraindications, dosage, administration, and storage/stability. It inhibits bacterial cell wall synthesis and has a peak blood level within 3 hours of intramuscular administration. It is used to treat moderately severe infections caused by susceptible streptococci and pneumococci, with dosage varying based on infection type and patient weight. It should be stored refrigerated and protected from freezing.

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dwyane0033
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148 views

Drug Study

This document summarizes information about Penicillin G Benzathine/Penicillin G Procaine, including its trade names, pharmacology, pharmacokinetics, indications and usage, contraindications, dosage, administration, and storage/stability. It inhibits bacterial cell wall synthesis and has a peak blood level within 3 hours of intramuscular administration. It is used to treat moderately severe infections caused by susceptible streptococci and pneumococci, with dosage varying based on infection type and patient weight. It should be stored refrigerated and protected from freezing.

Uploaded by

dwyane0033
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
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Penicillin G Benzathine / Penicillin G Procaine

Pronunciation: (pen-i-SIL-in G BENZ-ah-theen/pen-i-SIL-in G PRO-cane)


Class: Natural penicillin
Trade Names:
Bicillin C-R
- Injection 600,000 units/dose (300,000 units each penicillin G benzathine and penicillin
G procaine)
- Injection 1,200,000 units/dose (600,000 units each penicillin G benzathine and
penicillin G procaine)
Trade Names:
Bicillin C-R 900/300
- Injection 1,200,000 units/dose (900,000 units penicillin G benzathine and 300,000 units
penicillin G procaine)

Pharmacology

Inhibits mucopeptide synthesis of bacterial cell wall.

Pharmacokinetics

Absorption

Following IM administration, peak blood levels occur within 3 h.

Indications and Usage

Treatment of moderately severe infections caused by penicillin G-susceptible


microorganisms that are susceptible to serum levels common to this particular dosage
form; moderately severe to severe infections of the upper respiratory tract, scarlet fever,
erysipelas, and skin and soft tissue infections caused by susceptible streptococci;
moderately severe pneumonia and otitis media caused by susceptible organisms. Severe
pneumonia, empyema, bacteremia, pericarditis, meningitis, peritonitis, and arthritis of
pneumococcal etiology are better treated with penicillin G sodium or potassium during
the acute stage. When high, sustained serum levels are required, use penicillin G sodium
or potassium IM or IV. This drug should not be used in the treatment of venereal
diseases, including bejel, gonorrhea, pinta, syphilis, and yaws.

Contraindications

Hypersensitivity to any penicillin or to procaine.

Dosage and Administration


Streptococcal Infections Group A (upper respiratory tract, skin and soft tissue
infections, scarlet fever, and erysipelas)
Adults and Children more than 60 lbs

IM 2,400,000 units.

Children 30 to 60 lbs

IM 900,000 to 1,200,000 units.

Children less than 30 lbs

IM 600,000 units.

Pneumococcal Infections (except pneumococcal meningitis)


Adults

IM 1,200,000 units repeated every 2 or 3 days until temperature is normal for 48 h.

Children

IM 600,000 units repeated every 2 or 3 days until temperature is normal for 48 h.

Storage/Stability

Store in refrigerator (36° to 46°F). Protect from freezing.

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