DRUG STUDY

Name of Patient: Patient’s Health Profile:

Name of Classification Mechanism of action Contraindication Route and Side Effects Nursing Responsibilities
the Drug Dosage
Rifampicin: Ethambutol: Rifampicin: • The tablets should be taken 1 hr
1. Fixcom 4 Anti-TB Agents Bactericidal. Inhibits • Children <6 For the initial Hepatitis, orange-red before or 2 hrs after meals to
mycobacterial RNA years phase: Fixcom 4 is urine, sweat and facilitate absorption.
synthesis by binding to • Children <13 given for 2 months tears, GI • Monitor liver function test results
DNA-dependent RNA years as follows: disturbances, nausea before and every 2 to 4 weeks
polymerase, thereby • Patients with & vomiting, rashes, during therapy. Immediately
blocking RNA synthesis Visual defects & • Patients <55 kg: fever, headache report abnormalities.
and subsequent Optic Neuritis 3 tabs/day. PO. • Expect skin to discolor and body
translation to proteins. Isoniazid: fluids reddish orange to reddish
Pyrazinamide: • Patients 55-70 Peripheral neuritis, brown, nausea and vomiting,
Isoniazid: Bactericidal. Liver Damage kg: hepatitis, fever, rash, epigastric distress, skin rashes,
Inhibits mycolic acid 4 tabs/day. PO. visual disturbances drowsiness, fatigue.
• Acute gout or
synthesis resulting in • Take this drug regularly; avoid
Hyperuricemia
loss of acid-fastness Patients >70 kg: Pyrazinamide: missing any doses; do not
and bacterial cell wall 5 tabs/day. PO. Hypersensitivity, discontinue this drug without
Rifampicin
disruption. Hepatitis, Fever, consulting your health care
• Jaundice
porphyria, dysuria, provider.
Pyrazinamide: GI disturbances, • Have periodic medical checkups,
Bactericidal. Inhibits including eye examinations and
the growth of Ethambutol: blood tests, to evaluate the drug
Mycobacterium Retrolobular neuritis, effects.
tuberculosis by visual field
• Do not drink alcohol, or drink as
decreasing its pH level. constriction, central
little as possible. There is an
or peripheral
increased risk of hepatitis.
Ethambutol: scotoma, green-red
Bactericidal. Interferes color blindedness, • Instruct patient to report
with RNA synthesis, fever, confusion, darkened urine, fever, chills,
causing suppression of headache, rashes, GI nausea, severe pain in feet or
Mycobac. disturbances toes, vomiting and yellowing of
multiplication. It acts skin and eyes, muscle and bone
on rapidly growing pain, excessive tiredness or
pathogens in cavity weakness, loss of appetite,
walls. unusual bleeding or bruising,
changes in vision