DRUG STUDY

Prescribed and
Generic Name Recommended
Mechanism of Nursing
Brand Name Dosage, Frequency, Indication Contraindication Adverse Reaction
Action Responsibilities
Classification and Route of
Administration
Propofol: Induction and Propofol is a short-  Induction and Electroconvul- Involuntary muscle 1. Patient must be
acting anesthetic maintenance sive therapy, movements; nausea, Intubated and
maintenance
 Diprifol amp obstetrics. vomiting, headache, ventilated
given for induction of general
emulsion injection of general anesthesia anesthesia Sedation in fever; pain, burning 2. Monitor: HR, ECG,
Adult: Induction: 40 mg and maintenance of
 Diprivan amp children ≤16 yr. or stinging at Pulse Ox, BP
general anesthesia.  Sedation 3. Abrupt
 Diprivan pre- by injection or infusion Pregnancy, injection site.
Onset: 30 seconds. lactation. egg Potentially discontinuation of
filled syringe every 10 seconds.
Duration: 3-10 hypersensitivity, Fatal: Apnea, infusion may result in
 Fresofol 1% amp Usual dose: 1.5-2.5 minutes. soya lecithin bradycardia, rapid awakening with
 Hospira Propofol mg/kg. Maintenance: 4- Distribution: Extensi hypersensitivity; hypotension, agitation, anxiety
vial 12 mg/kg/hr or use cautiously in convulsions; 4. Discard tubing/bottle
vely redistributed from
intermittent bolus hypotensive anaphylaxis after 12 hours
 IV-Pro solution brain to other tissues;
injection of 20-50 mg.  patients 5. Do not use if
for IV infusion crosses the placenta emulsion appears
 Lipuro amp Child: >8 yr: Induction and enters breast separated
 Lipuro IV- dose of 2.5 mg/kg. milk. Protein-binding: 6. Maintain strict aseptic
infusion Maintenance dose: 9- 95% technique because
15 mg/kg/hr by IV Metabolism: Extensiv emulsion will support
rapid growth of
infusion or intermittent ely hepatic; converted
microorganisms.
bolus injection.  to water-soluble 7. If hypotension or
Elderly: Including sulfate and bradycardia occurs,
neurosurgical and glucuronide decrease or stop
debilitated patients: conjugates. Diprivan and monitor
Infuse at a rate of 20 Excretion: Urine (as BP & HR, notifyMD
metabolites); feces. 8. Document neuro
mg every 10 seconds. assessment on
Maintenance: 3-6 Elimination half-life:40
awakening (Ramsey
mg/kg/hr. Usual dose min (initial); 4-7 hr Level of Sedation
Scale)
 DRUG STUDY

Prescribed and
Generic Name Recommended
Mechanism of Nursing
Brand Name Dosage, Frequency, Indication Contraindication Adverse Reaction
Action Responsibilities
Classification and route of
Administration
needed: 1-1.5 (terminal)
mg/kg.Intravenous

Sedation
Adult: In diagnostic
and surgical
procedures: Initially, 6-
9 mg/kg/hr by infusion
given for 3-5 minutes or
an alternative dose of
0.5-1 mg/kg by slow
injection over 1-5
minutes.
Maintenance: 1.5-4.5
mg/kg/hr infusion.
Reduce maintenance
dose by 20% for high-
risk patients needing
sedation. For ventilated
patients: 0.3-4 mg/kg/hr
by infusion. Monitor
lipid concentrations if
duration of sedation
lasts >3 days.