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Central Dogma Part 1

The central dogma of molecular biology states that genetic information flows from nucleic acids to proteins but cannot flow back from proteins to nucleic acids or between nucleic acid types. It provides a fundamental framework for understanding the transfer of genetic information.

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Josh Rosenberg
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195 views

Central Dogma Part 1

The central dogma of molecular biology states that genetic information flows from nucleic acids to proteins but cannot flow back from proteins to nucleic acids or between nucleic acid types. It provides a fundamental framework for understanding the transfer of genetic information.

Uploaded by

Josh Rosenberg
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPT, PDF, TXT or read online on Scribd
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Central Dogma of Molecular Biology

The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information. It states that such information cannot be transferred back from protein to either protein or nucleic acid.
Francis Crick, 1958

in other words

Protein information cannot flow back to nucleic acids


Fundamental framework to understanding the transfer genetic information

The Basics: Cell Organization


Prokaryotes

Eukaryotes

The Basics: Structure of DNA

The Basics: Additional Points


DNA => A T C G RNA => A U C G


Not all DNA is found in chromosomes

Mitochondria Viruses and Plasmids

an example of a plasmid vector

Gene of interest Circular DNA

DNA Replication

The process of copying double-stranded DNA molecules Semi-conservative replication

Each strand is used as a template

DNA Replication: Enzymes involved


Initiator proteins (DNApol clamp loader) Helicases SSBPs (single-stranded binding proteins) Topoisomerase I & II DNApol I repair DNApol II cleans up Okazaki fragments DNApol III main polymerase DNA primase DNA ligase

DNA Replication:

Transcription

Process of copying DNA to RNA Differs from DNA synthesis in that only one strand of DNA is used to make mRNA Can involve multiple RNA polymerases Divided into 3 stages

Initiation Elongation Termination

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