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MDMA Powerpoint

A 16-year-old male presents with symptoms including headache, nausea, muscle twitching, confusion, euphoria, flushing, sweating, heart palpitations, dilated pupils, and dry mouth. His diagnosis is serotonin syndrome, likely induced by MDMA (ecstasy). MDMA enhances the release of catecholamines and inhibits their reuptake, increasing neurotransmitters in the synaptic cleft and enhancing postsynaptic activation. However, MDMA overdose can cause effects like dizziness, tremor, hypertension, sweating, dilated pupils, arrhythmias, hyperthermia, seizures, coma, and brain hemorrhage.

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170 views16 pages

MDMA Powerpoint

A 16-year-old male presents with symptoms including headache, nausea, muscle twitching, confusion, euphoria, flushing, sweating, heart palpitations, dilated pupils, and dry mouth. His diagnosis is serotonin syndrome, likely induced by MDMA (ecstasy). MDMA enhances the release of catecholamines and inhibits their reuptake, increasing neurotransmitters in the synaptic cleft and enhancing postsynaptic activation. However, MDMA overdose can cause effects like dizziness, tremor, hypertension, sweating, dilated pupils, arrhythmias, hyperthermia, seizures, coma, and brain hemorrhage.

Uploaded by

api-26938624
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPT, PDF, TXT or read online on Scribd
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Pharmacology Case 1d

Natalia Bright
Carine Jacques
Maureen MacDonald
Kathy Van Zeyl
Case 1d
 A 16 y.o. male presents with
headache, nausea, muscle twitching,
confusion, a sense of euphoria, a
flushed face with sweating, heart
palpitations, mydriasis, and
complains of a dry mouth.
 Vitals: 39.3 Celsius, BP: 138/90,
P: 100, RR:18
 DDX?
Ddx:
 1) Acute anticholinergic syndrome

 2) Neuroleptic malignant syndrome

 3) Serotonin syndrome
Diagnosis:

 Serotonin
Syndrome!!!
(Likely induced by
MDMA -
methylenedioxyme
thamphetamine,
also known as
ecstasy)
Quiz Question 1
 Which of the following
is NOT a common
nickname for ecstasy
abuse?:

a) “murfing” (Canada)

b) “thizzing” (UK)

c) “tripping balls” (Canada)

d) “banana hammocking”
(U.S.)
Physiological Effects of MDMA
How does MDMA work in the body?
 It enhances the release of

catecholamines from presynaptic


terminals and inhibits their neuron
reuptake. Consequently, the
neurotransmitter content in the
synaptic cleft is increased, resulting
in enhanced postsynaptic activation.
Physiological Effects of MDMA

 In overdose, MDMA causes dizziness,


tremor, irritability, hypertension,
diaphoresis, mydriasis, cardiac
arrythmias, hyperpyrexia,
convulsions, coma and cerebral
haemorrhage.
Quiz Question 2
 In an MDMA overdose, which of the
following physiological effects would
lead to memory deficits:
a) Mydriasis
b) Dizziness
c) Tremor
d) Cerebral haemorrhage
Conventional Drug Treatment
Options for MDMA Dependency
Research Initiatives

 1. Animal research

 2. Human research
Detoxification of the Body

 1. Physical

 2. Mental

 3. Emotional
Pharmaceutical Approaches

 1. Emergency

 2. Long-Term Rx
Was the Trip Worth it?
Quiz Question 3
Which of the following provides
100% protection against the
effects of ecstasy?:

a) Eating a turkey sandwich after


you go out (tryptophan for
conversion to 5-HT)

b) Drink lots of water and hope for


the best

c) Take only as much “E” until you


hit your sweet spot

d) Abstinence – Just Don’t Do It



Naturopathic recommendations

 Herbal ecstasy formulas?

 Antioxydants?

 5-HTP supplements?

 Holistic detoxification services


Quiz Question 4
 What supplement
is known as a
precursor to the
neurotransmitter
serotonin?
a) 6-ATP
b) 5-HTP
c) amphetamines
d) Sweet Tarts and
Rockets candy

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