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Structure of Skeletal Muscle

The document summarizes the structure of skeletal muscle in three paragraphs. It describes the structure from the macroscopic level down to the microscopic and ultrastructural levels. Key points include that skeletal muscle forms 40% of body weight, is striated and multinucleated. At the microscopic level it has dark A bands and light I bands. At the ultrastructural level it contains thick myosin filaments that form cross bridges with thin actin filaments, regulated by tropomyosin and troponin.

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nirilib
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1K views

Structure of Skeletal Muscle

The document summarizes the structure of skeletal muscle in three paragraphs. It describes the structure from the macroscopic level down to the microscopic and ultrastructural levels. Key points include that skeletal muscle forms 40% of body weight, is striated and multinucleated. At the microscopic level it has dark A bands and light I bands. At the ultrastructural level it contains thick myosin filaments that form cross bridges with thin actin filaments, regulated by tropomyosin and troponin.

Uploaded by

nirilib
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as PPT, PDF, TXT or read online on Scribd
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Dr.

Niranjan Murthy H L
Asst. Prof., Dept. of Physiology
Sree Siddhartha Medical College & Hospital, Tumkur
STRUCTURE OF SKELETAL
MUSCLE

• Forms 40% of body weight


• Locomotion
• Striated or voluntary
• Multinucleated
Sarcolemma-
• Consists of an inner plasma membrane and
outer collagenous layer
• Invaginates at numerous points to form T-
tubules
• Carries action potential
Sarcoplasm-
• Consists of myofibrils
• Numerous mitochondriae
lying parallel to myofibrils
Sarcoplasmic reticulum-
• L-tubules
• Storage of calcium ions
• Skeletal muscle
• Fasciculus
• Muscle fibers
• Myofibrils
• Myofilaments
• Muscle fiber- 10 to 80μ in diameter each is
composed of 1000s of myofibrils

• Each myofibril is in turn made up of


myofilaments

• Myofilaments
(i) contractile- myosin II, actin
(ii) modulatory- tropomyosin, troponin
LIGHT MICROSCOPIC STRUCTURE
• Cross striations due to alternate dark and light bands
• Light band- Isotropic band- I band- thin filaments
• Dark band- Anisotropic band- A band- birefringent
• H zone- lighter zone in A band
• Z line- in the center of I band
• M line- in the center of A band
• Sarcomere- between two z lines- basic unit of muscle
ULTRASTRUCTURE
• Myofilaments- thick & thin filaments
• Myosin-10 to 14nm wide & 1.6μm long
1500 in each myofibril
Myosin filament made of around 200molecules of myosin
• Myosin molecule- composed of 6 polypeptide chains- 2 heavy
chains and 4 light chains
A tail, an arm and 2 globular heads
Arm and head form cross-bridge
Two hinges
Head has sites for ATP and actin binding
• Actin filament- 7nm wide and 1.0μm long
Extend on both sides of z-lines
F-actin forms a double helix
Made of 300 G-actin molecules (MW 42,000)
G-actin has active sites for interaction with
myosin heads
• Tropomyosin- 40nm length and MW of
70,000.
Wrapped around actin helix & covers
active sites in resting phase

• Troponin- made of 3 protein subunits


(Tn I, Tn C & Tn T)
OTHER PROTEINS

3) Actinin- binds actin to Z lines

2) Desmin- binds Z lines to the plasma


membrane

3) Titin- connects Z lines to M lines and provide


scaffolding for sarcomere. Provides elasticity

4) Dystrophin, dystroglycans and sarcoglycans

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