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Reactor Design For Enzyme Catalyzed Reactions: K E K S K S E K DT DS

The document discusses various reactor designs for enzyme-catalyzed reactions, including batch reactors, continuous stirred-tank reactors (CSTRs), and packed bed reactors. It provides kinetic equations that describe zero-order and first-order reactions for different conditions. CSTRs are noted as being useful for pH control and processing insoluble substrates or colloids. Packed bed reactors can achieve higher conversion and yields for reactions involving product inhibition. Factors to consider for ideal enzyme reactors include heat and mass transfer limitations, use of soluble or insoluble substrates, enzyme recycling, and scaling challenges.

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Joanna Hoang
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70 views

Reactor Design For Enzyme Catalyzed Reactions: K E K S K S E K DT DS

The document discusses various reactor designs for enzyme-catalyzed reactions, including batch reactors, continuous stirred-tank reactors (CSTRs), and packed bed reactors. It provides kinetic equations that describe zero-order and first-order reactions for different conditions. CSTRs are noted as being useful for pH control and processing insoluble substrates or colloids. Packed bed reactors can achieve higher conversion and yields for reactions involving product inhibition. Factors to consider for ideal enzyme reactors include heat and mass transfer limitations, use of soluble or insoluble substrates, enzyme recycling, and scaling challenges.

Uploaded by

Joanna Hoang
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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2/23/2012

Reactordesignforenzyme catalyzedreactions

BatchReactor
dS k 2 E0 S k E 2 0 dt K m S K m 1 S S ln( 0 ) S S0 K m ln( ) S 0 S k 2 E0t S 0 S S S ln( 0 ) S 1 k 2 E0 t S0 S K m K m (S0 S )
FindtheratelawconstantsVm andKM usingintegral method

t S0 S

2/23/2012

OtherFormats
K m ln( S0 ) S 0 S k 2 E0 t S

1 K m ln( ) S 0 X k 2 E0 t 1 X P S0 S S0 ) P k 2 E0 t S0 P

K m ln(

1 K m ln( ) S 0 X k 2 E0 t 1 X
If Km<< S0, zero order reaction

S0 X k 2 E0

If Km>> S0, first order reaction


K m ln(1 X ) k 2 E0t

2/23/2012

CSTR
v0 S 0 v0 S rSV v0 ( S 0 S ) k 2 E0 S V Km S
If Km<< S0, zero order reaction

S0 X k 2 E0

k ES (S0 S ) 2 0 Km S k 2 E0 S 0 X K m X 1 X

If Km>> S0, first order reaction


Km X k 2 E0 1 X

HowaboutPFR?

2/23/2012

Idealenzymereactor
Factorsthatneededtobeconsidered:

2/23/2012

BatchReactor Goodforsmallscale experimentalstudy Useofsoluble enzyme Operational convenience Canuseinsoluble substrate

CSTR
EasytodopHcontrol Colloidial orinsoluble substratecanbe processed Easyreplacementof catalyst Higheryieldforreaction undergoingsubstrate inhibition

2/23/2012

CSTRmembrane
1. 2. Abilitytouseandrecycle solubleenzyme Enzymelossdueto adsorptiononthe membrane Concentration polarizationofthe enzymeatthe membranesurface Poorstabilityforthe enzymeforlongterm operation

3.

4. Enzyme recycle product

PackedBedReactor
Higherconversion (comparedtoCSTR) Higheryieldfor reactionundergoing productinhibition

2/23/2012

FluidizedBedReactor
1. Betterheatandmass transfer 2. Insolublesubstratecan beused 3. Lowpressuredrop 4. Largepower requirementsforfluiding thebed 5. Uncertaintyinscalingup

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