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Autisme 2

This document is a call for papers for a special issue of the journal Autism Research and Treatment on the topic of how genetics and the immune system intersect in autism. It provides background on autism as a neurodevelopmental disorder with strong genetic underpinnings. While many genes and genetic variants have been associated with autism, they do not fully explain most cases. Emerging evidence suggests prominent immune abnormalities in many autistic individuals and their relatives. The special issue seeks manuscripts that address how abnormal immunity may be genetically driven and compatible with autism's high heritability, and how abnormal immunity may be responsible for or merely associated with the autistic phenotype. Potential topics of interest are listed.

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40 views

Autisme 2

This document is a call for papers for a special issue of the journal Autism Research and Treatment on the topic of how genetics and the immune system intersect in autism. It provides background on autism as a neurodevelopmental disorder with strong genetic underpinnings. While many genes and genetic variants have been associated with autism, they do not fully explain most cases. Emerging evidence suggests prominent immune abnormalities in many autistic individuals and their relatives. The special issue seeks manuscripts that address how abnormal immunity may be genetically driven and compatible with autism's high heritability, and how abnormal immunity may be responsible for or merely associated with the autistic phenotype. Potential topics of interest are listed.

Uploaded by

rain_day
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Autism Research and Treatment

Special Issue on Autism: Where Genetics Meets the Immune System


Call for Papers
Autism is a neurodevelopmental disorder diagnosed by 3 years of age on the basis of impaired social interaction and communication, as well as presence of rigid and stereotyped behaviors. Altered prenatal and early-postnatal neurodevelopment plays a pivotal role in autism pathogenesis. Family and twin studies have conclusively demonstrated that autism displays the most prominent genetic contributions among all neuropsychiatric disorders. Yet, the identication of these genetic underpinnings has proven more complex than anticipated, and two decades of genetic investigation have unveiled relatively few cases which can be solely explained on the basis of de novo mutations or cytogenetic abnormalities. The vast majority of gene variants or CNVs associated with autism either confer vulnerability or protection but do not directly cause the disease. While this may stem from genetic heterogeneity, epigenetic events, gene-gene and gene-environment interactions, converging lines of evidence support prominent immune abnormalities in many autistic individuals and even in their rst-degree relatives, as well as relevant roles in neurodevelopment for molecules traditionally identied as involved in innate or acquired immunity. This crosstalk between the nervous and immune system poses some questions fundamental to the denition of a pathophysiological construct able to explain autism in most cases. We are particularly interested in manuscripts addressing, under any perspective, two critical questions: (a) how and to what extent is abnormal immunity compatible with high heritability in autism? Is it genetically driven? And (b) how and to what extent is abnormal immunity responsible for the autistic phenotype? Or is it merely an innocent by-standing condition with no immediate link to autistic symptoms? Potential topics include, but are not limited to:
Autism genes playing functional roles in the immune Peripheral markers of abnormal immunity in ASD Microglial activation, cytokines, and neuropathology Physiological roles for immune molecules in neurode-

velopment
Animal models of autism implicating altered immu-

nity
Altered immunity as a familial endophenotype in ASD Immune-based pharmacological interventions

Before submission authors should carefully read over the journals Author Guidelines, which are located at http://www .hindawi.com/journals/aurt/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: Manuscript Due First Round of Reviews Publication Date Lead Guest Editor Antonio M. Persico, Laboratory of Molecular Psychiatry & Neurogenetics, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy; [email protected] Guest Editors Carlos A. Pardo-Villamizar, Department of Neurology, The Johns Hopkins Hospital, Pathology Building, Room 627, 600 N. Wolfe Street, Baltimore, MD 21287, USA; [email protected] Judy Van De Water, Division of Rheumatology/Allergy and Clinical Immunology, UC Davis, 451 Health Science Drive, Suite 6510, GBSF, Davis, CA 95616, USA; [email protected] September 15, 2011 December 15, 2011 March 15, 2012

system
Immune abnormalities in syndromic forms of autism

due to genetic mutations or chromosomal rearrangements Inuence of immune system responses on neurodevelopment and the risk of ASD Environmental-immune interactions during development and ASD pathogenesis

Hindawi Publishing Corporation http://www.hindawi.com/

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