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XLK XLK Syllabus GATE

This syllabus outlines the topics to be covered in a microbiology course, including: 1) the historical discoveries in microbiology and techniques used to study microbes; 2) the taxonomy, diversity and structures of prokaryotic and eukaryotic microorganisms; and 3) additional topics such as microbial growth and metabolism, diseases and host-pathogen interactions, chemotherapy and antibiotics, and microbial genetics and ecology.

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75 views2 pages

XLK XLK Syllabus GATE

This syllabus outlines the topics to be covered in a microbiology course, including: 1) the historical discoveries in microbiology and techniques used to study microbes; 2) the taxonomy, diversity and structures of prokaryotic and eukaryotic microorganisms; and 3) additional topics such as microbial growth and metabolism, diseases and host-pathogen interactions, chemotherapy and antibiotics, and microbial genetics and ecology.

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SYLLABUS FOR MICROBIOLOGY (XL: SECTION K)

(Optional Section) Historical Perspective:


Discovery of microbial world; Landmark discoveries relevant to the field of microbiology; Controversy over spontaneous generation; Role of microorganisms in transformation of organic matter and in the causation of diseases.

Methods in Microbiology:
Pure culture techniques; Theory and practice of sterilization; Principles of microbial nutrition; Enrichment culture techniques for isolation of microorganisms; Light-, phase contrast- and electron-microscopy.

Microbial Taxonomy and Diversity:


Bacteria, Archea and their broad classification; Eukaryotic microbes: Yeasts, molds and protozoa; Viruses and their classification; Molecular approaches to microbial taxonomy.

Prokaryotic and Eukaryotic Cells:


Structure and Function

Prokaryotic Cells:
cell walls, cell membranes, mechanisms of solute transport across membranes, Flagella and Pili, Capsules, Cell inclusions like endospores and gas vesicles; Eukaryotic cell organelles: Endoplasmic reticulum, Golgi apparatus, mitochondria and chloroplasts.

Microbial Growth:
Definition of growth; Growth curve; Mathematical expression of exponential growth phase; Measurement of growth and growth yields; Synchronous growth; Continuous culture; Effect of environmental factors on growth.

Control of Micro-organisms:

Effect of physical and chemical agents; Evaluation of effectiveness of antimicrobial agents.

Microbial Metabolism:
Energetics: redox reactions and electron carriers; An overview of metabolism; Glycolysis; Pentose-phosphate pathway; Entner-Doudoroff pathway; Glyoxalate pathway; The citric acid cycle; Fermentation; Aerobic and anaerobic respiration; Chemolithotrophy; Photosynthesis; Calvin cycle; Biosynthetic pathway for fatty acids synthesis; Common regulatory mechanisms in synthesis of amino acids; Regulation of major metabolic pathways.

Microbial Diseases and Host Pathogen Interaction:


Normal microbiota; Classification of infectious diseases; Reservoirs of infection; Nosocomial infection; Emerging infectious diseases; Mechanism of microbial pathogenicity; Nonspecific defense of host; Antigens and antibodies; Humoral and cell mediated immunity; Vaccines; Immune deficiency; Human diseases caused by viruses, bacteria, and pathogenic fungi.

Chemotherapy/Antibiotics:
General characteristics of antimicrobial drugs; Antibiotics: Classification, mode of action and resistance; Antifungal and antiviral drugs.

Microbial Genetics:
Types of mutation; UV and chemical mutagens; Selection of mutants; Ames test for mutagenesis; Bacterial genetic system: transformation, conjugation, transduction, recombination, plasmids, transposons; DNA repair; Regulation of gene expression: repression and induction; Operon model; Bacterial genome with special reference to E.coli; Phage and its life cycle; RNA phages; RNA viruses; Retroviruses; Basic concept of microbial genomics.

Microbial Ecology:
Microbial interactions; Carbon, sulphur and nitrogen cycles; Soil microorganisms associated with vascular plants.

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