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This document provides information on the drug Amodis, including its composition, indications, dosage, administration, adverse reactions, drug interactions, pharmacology, and storage. Amodis contains metronidazole and is available as 400mg or 500mg tablets or 200mg/5ml suspension. It is used to treat various parasitic infections caused by protozoa and anaerobic bacteria, as well as bacterial vaginosis, dental infections, surgical prophylaxis, and more. Dosage varies depending on the condition and patient age but is typically 200-800mg taken 2-4 times daily. Common side effects include metallic taste and nausea. Amodis should not be used during pregnancy and can interact with other

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106 views

Leaflet

This document provides information on the drug Amodis, including its composition, indications, dosage, administration, adverse reactions, drug interactions, pharmacology, and storage. Amodis contains metronidazole and is available as 400mg or 500mg tablets or 200mg/5ml suspension. It is used to treat various parasitic infections caused by protozoa and anaerobic bacteria, as well as bacterial vaginosis, dental infections, surgical prophylaxis, and more. Dosage varies depending on the condition and patient age but is typically 200-800mg taken 2-4 times daily. Common side effects include metallic taste and nausea. Amodis should not be used during pregnancy and can interact with other

Uploaded by

Mostafa Kamal
Copyright
© © All Rights Reserved
Available Formats
Download as PDF, TXT or read online on Scribd
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Amodis

Metronidazole BP

COMPOSITION
Amodis 400 Tablet : Each film coated tablet contains Metronidazole BP 400 mg.
Amodis 500 Tablet : Each film coated tablet contains Metronidazole BP 500 mg.
Amodis Suspension : Each 5 ml contains Benzoyl Metronidazole equivalent to Metronidazole BP
200 mg.

DOSAGE & ADMINISTRATION


If not otherwise prescribed by the physician the following dosage schedule may be followed :
Duration Adult & Children
of dosage over 10 years
in days

Trichomoniasis**

7
2

Invasive intestinal
amoebiasis
Extra intestinal
amoebiasis (including
liver abscess) and
symptomless amoebic
cyst passers

Children
7-10 years
100 mg t.i.d.
-

3-7 years
100 mg b.i.d.
-

200 mg t.i.d. or 400 mg b.i.d.


800 mg in the morning and
1.2 gm at night
2.0 gm as a single dose

800 mg t.i.d.

400 mg t.i.d.

200 mg q.i.d.

200 mg t.i.d.

400 -800 mg t.i.d.

200 -400 mg t.i.d

2.0 gm once daily

1.0 gm once daily

600-800 mg
once daily

500 mg
once daily

Acute ulcerative gingivitis

200 mg t.i.d.

100 mg t.i.d.

100 mg b.i.d.

50 mg t.i.d.

Acute dental infections


Bacterial vaginosis

3 -7
57
1

200 mg t.i.d.
400500 mg twice daily
2.0 gm as a single dose

ADVERSE REACTION
Metalic taste, furred tongue, nausea, vomiting, diarrhoea, drowsiness, rashes and mild reversible
leucopenia may be observed during treatment.

Leg ulcers and


pressure sores
Anaerobic infections

400 mg t.i.d.

DRUG INTERACTION
Metronidazole interacts with warfarin, nicoumalone, phenytoin, phenobarbitone, fluorouracil,
disulfiram, lithium, cimetidine etc.

Surgical prophylaxis

INDICATION
All forms of amoebiasis (intestinal and extra-intestinal disease including liver abscess and that of
symptomless cyst passers) Trichomoniasis Giardiasis
Bacterial vaginosis Acute ulcerative
gingivitis Anaerobic infections including septicaemia, bacteraemia, peritonitis, brain abscess,
necrotising pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis etc.
Anaerobically-infected leg ulcers and pressure sores
Acute dental infections (e.g. acute
pericoronitis and acute apical infections) Surgical prophylaxis (prevention of postoperative
infections due to anaerobic bacteria, particularly species of bacteroides and anaerobic streptococci
Chronic symptomatic peptic ulcer disease (as an agent of triple therapy to eradicate H. pylori-the
most important aetiological factor of peptic ulcer)

Giardiasis

5-10

1-3 years
50 mg t.i.d.
-

Either 400 mg every 8 hours


or 500 mg every 8 hours
400500 mg 2 hours
before surgery;
up to 3 further doses of
400500 mg
may be given every 8
hours for
high-risk procedures

100-200 mg q.i.d 100 -200 mg t.i.d

7.5 mg/kg t.i.d.

7.5 mg/kg t.i.d

7.5 mg/kg t.i.d.

7.5 mg/kg t.i.d. 7.5 mg/kg t.i.d.

7.5 mg/kg t.i.d

PREGNANCY & LACTATION


Not recommended during first & later trimesters. Breast feeding should be delayed until 48 hours
after discontinuing metronidazole in the mother.

**Trichomoniasis: Concomitant treatment of sexual consorts is recommended.

STORAGE CONDITION
Tablet: Store in a cool and dry place. Protect from light and moisture. Keep out of the reach of
children. Suspension: Store in a cool and dry place. Protect from light. Keep out of the reach of
children.

HOW SUPPLIED
Amodis 400 Tablet : Box containing 200 tablets in blister pack.
Amodis 500 Tablet : Box containing 100 tablets in blister pack.
Amodis Suspension : Each PET bottle contains 60 ml suspension with measuring cup.
Manufactured by :

Registered Trade Mark.

Revision No.: 03

PHARMACOLOGY
Amodis (Metronidazole), a nitroimidazole has an extremely broad spectrum antiprotozoal and
antimicrobial activities, with high activity against anaerobic bacteria and protozoa. Amodis
(Metronidazole) is usually completely and rapidly absorbed after oral administration. The half-life in
plasma is about 8 hours. About 10% of the drug is bound to plasma proteins. Amodis
(Metronidazole) penetrates well into body tissues and fluids. The liver is the main site of metabolism.
Both unchanged Metronidazole and metabolites are excreted in various proportions in the urine
after oral administration.

Indication

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