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CHAPTER 10

PERSONALITY AND PERSONALITY DISORDER

Illustration. Can you spot the differences? These are pictures of two human beings,
both are holding a toy bear above their heads in their right hands. One picture is taken
outside in daylight and the other is taken indoors at night. One individual is young and
female, the other is old and male. Can you make a guess at possible personality
differences? The female looks more extraverted and fun loving, the male looks more
conservative and grumpy. Like the ESR, the appearance gives potentially useful
information about the individual, but further information is required before
conclusions can be reached. Does either or both have a personality disorder? Bad
question. A diagnosis of personality disorder cannot be made on limited information.
The female is a former porn actress who made a successful transition into the Italian
parliament. The male is the author of these words. They are probably both different
or eccentric, but probably neither has a diagnosable personality disorder.

Introduction
Personality disorder depends on indefinite conceptual issues. The following pages
attempt a practical approach. In most textbooks of psychiatry the personality disorders
appear just before the index. They are shoved to the back, and many students assume
the personality disorders lack importance.
On the contrary, personality disorders are important form the perspective of both
prevalence and consequence. People with personality disorder constitute up to 20% of
the general population, at least 15% of psychiatric outpatients, and at least 10% of
psychiatric inpatients.
Students encounter people with personality disorder more frequently than these
prevalence figures might suggest. People with personality disorders are frequent
attendees at public hospital Emergency Departments, as a result of social crises,

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injuries from fights, alcohol or drug intoxication or with self-injuries. People with
personality disorders are often encountered as inpatients following over-doses and
because of they have difficulty managing any other chronic disorder which they may
suffer.
Co-morbid personality disorder makes the management of other psychiatric disorders
such as schizophrenia and bipolar disorder more problematic. Thus, while only 10%
of the inpatients of public hospital psychiatric units have personality disorder as their
primary disorder, many other psychiatric patients will be co-morbid for personality
disorder.

Personality
There are many definitions of personality. Perhaps the most parsimonious is that
personality is those features of the individual which determine that individuals
unique adjustment to the environment. Expanded descriptions add that personality is
lifelong and persistent (although personality changes somewhat over time, and can
be changed through sustained psychotherapy), and involves enduring characteristics
and attitudes which influence the individuals ways of thinking, feeling and
behaving.
I had thought Freud had said that a healthy personality was demonstrated by the
ability to love and work. With a view to presenting a pithy statement, I located his
exact words, and I had remembered them incorrectly. Freud actually said, Love and
work are the cornerstones of our humanness; which is not the same thing, but the
ideas are close. To be a able to love means to be able to be warm, supportive,
encouraging, intimate, forgiving and respectful of others; to be able to work means to
be able to accept responsibility for ones actions, take directions, expend effort in
spite of lacking energy and to delay gratification (delay what one would like to
have/do for a time, while other things such as education are achieved).

Normal versus abnormal

It is impossible to know exactly what and how another person thinks and feels
(Illustration). What may be adaptive in Beirut may be maladaptive in Sydney, what is
humorous in Melbourne may be insulting in Kalgoorlie, next-door neighbours may
fanatically support opposing football team, or one may have no interest in sport
whatsoever. Thus, the concept of normal must be approached with caution.
Normal is sometimes taken to mean with no impediment whatsoever. This meaning
was adopted by the World health Organization when it defined health as a state of
complete mental and physical well-being.
Normal may also mean average. Personality features obey the normal distribution
curve, with the majority of the population registering in the middle of the graph and
with a few individuals at the extremes. In the statistical sense those beyond 2 standard
deviations of the mean may be regarded as abnormal with respect to the dimension
under consideration (warmth, perfectionism, impulsivity).

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Illustration. This person, who has extremely long fingernails, appears to have different
values, at least in some regards, to the majority of readers. But further data are
required before comment can be made about personality structure.

Personality disorder
A Personality disorder is an enduring pattern of inner experience and behaviour that
deviates markedly from the expectations of the individuals culture, is pervasive and
inflexible, has an onset in adolescence or early adulthood, is stable over time and
leads to distress and impairment (DSM-IV-TR).
Exactly how the distress and impairment is to manifest is not clear. People with
neurotic disorders (an old fashioned term, an example is anxiety disorder) have
autoplastic defences meaning they react to stress by changing their internal
psychological process, and perceive their disorder as ego-dystonic meaning they
find their symptoms unacceptable, objectionable and needing to be changed. People
with personality disorders, in contrast, have alloplastic defences meaning they react
to stress by attempting to change the external environment (rather than themselves),
and perceive their symptoms (personality deficits) as ego-syntonic meaning they
find these aspect of themselves to be acceptable, unobjectionable and not in need of
change.
As people with personality believe the world should change to accommodate them
(rather than they adjust to the world) and view their own features as being acceptable
and not in need of change, they experience less distress as a direct result of their
personality disorder than might be expected. However, the world does not change to
suit them, and they experience much indirect distress as a result of their personality
disorder; that is, their maladaptive responses lead to failed relationships (with lovers,

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family and employers), losses and disappointments. These are the cause of great
distress.
Some authorities have observed that the individual with personality disorder
(particularly, antisocial personality disorder) generate distress in others, irrespective
of whether they experience distress themselves. This feature is not included in the
DSM-IV definition. The failure of the relationships and conflicts experienced by
people with personality disorder inevitably involve others, and naturally generate
distress in others.
The DSM-IV definition of personality disorder makes the point that the behaviour of
the individual is inflexible. It does not make the important point that the individual
with a personality has a limited repertoire, or number of ways of responding. Faced
with opposition the normal/average individual has a range of responses: to think of a
new approach, work harder and try again when better prepared, to use humour, to be
more assertive, to reassess whether the goal is worth further effort or not, etc. The
person with a personality disorder has a limited number of ways of responding (and,
for example may be largely limited to seduction or aggression). These are applied in
all situations, and because of the inflexibility of the individual, they are applied
repeatedly, even when they have already proved unsuccessful. In these circumstances
loss and disappointment, and direct and indirect distress are inevitable.
Cloninger et al (1993) described his Temperament and Character Inventory (TCI) an
important contribution to the study of personality. Self-determination and cooperativeness are 2 of the 7 TCI factors. High scores indicate a strong sense of
responsibility (self-determination) and agreeableness (co-operativeness). Cloninger et
al (1993) claim that low scores indicate the propensity to blame others (low selfdetermination) and self-centeredness (low co-operativeness), and personality disorder.

Dimensional model and assessment method

The view that we all share the same personality structure and that our personality
features (traits) can be registered on various continua is the theoretical basis of the
dimensional models of personality/personality disorder.
The main problem has been to identify and describe the dimensions which define
personality and to establish whether these dimensions are universal.
The Eysenck Personality Inventory (EPI) measures two separate dimensions:
extraversion-introversion (which measures reserved versus outgoing attitude) and
neuroticism (which measures emotional lability). The Cattell 16 Personality factor
Test (16PF) measures 16 different dimensions, and the Minnesota Multiphasic
Personality Inventory (MMPI) (probably the most widely used test of personality)
measures 10 different dimensions.
Zuckerman et al (1964) described a sensation-seeking scale (SSS), aspects of which
were incorporated into subsequent comprehensive personality tests.

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McCrae & John (1992) developed a five-factor model (FFM) of personality which has
been widely accepted. It employs the personality dimensions of, openness,
conscientiousness, extraversion, agreeableness, and neuroticism, known by the
acronym OCEAN.
Cloninger et al (1993) attempted to overcome the division between the dimensional
and the categorical models. They described four temperamental dimensions (noveltyseeking, harm avoidance, reward dependence, and persistence), which are present
from birth and are stable, and three character dimensions (self-direction, co-operation,
and self-transcendency) which are variable and modified by experience. They
consider that while the temperamental dimensions strongly influence behaviour, it is
the character dimensions which determine the presence or absence of personality
disorder. In particular, Cloninger et al (1993) find that low scores on self-direction
and co-operation are strongly associated with personality disorder.
Opponents of the questionnaire approach to personality assessment claim these
instruments have no ability to objectively assess the individuals capacity for effort,
stress tolerance, physical violence, enduring relationships, or the individuals
likableness.

Categorical model and assessment method

The categorical of model is used in the DSM-IV and ICD-10. It considers the
personality categories to be discontinuous.
There is much theory to recommend a dimensional approach (Siever & Davis, 1991),
and this remains the focus of students of normal personality. However, for clinical
purposes and the diagnosis of personality disorder, the categorical diagnostic system
is the dominant method, and is likely to remain so in the foreseeable future.
Given the existing categorical diagnostic system, and the limitations of the
dimensional models, the clinical interview with the patient and those who know the
patient well is currently the most useful diagnostic method. As personality determines
the adjustment to the environment, a detailed life history provides extensive
information regarding personality and likely future responses. The clinical interview
is also a test situation, providing practical, real-time examples of the patients manner
of self-presentation and response. The skilled interviewer will also make observations
regarding the interviewers own response to the patient, which is likely to be similar
to the responses of others.

Personality disorder as a mental disorder

There has been a view (not now widely held) that the personality disorders are not
like the other mental disorders, and even, that they should not be considered to be
mental disorders at all. The underpinning of this view included that personality
features can be located on a continuum with no clear demarcation between normal
and abnormal. Analogies were drawn with skin colour and height. Also, psychiatric
disorders such as Alzheimers disease and to a lesser extent, schizophrenia and

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bipolar disorder were associated with brain pathology (albeit only a group basis), but
this had not been shown for personality disorder.
Related confusion arose when the DSM placed disorders such as Alzheimers disease,
schizophrenia and bipolar disorder on Axis I, and personality disorders on Axis II.
A full exploration of this topic calls for discussion of the concepts of disease,
sickness, illness, disorder, deviance, acquired disorders and developmental problems,
and the role and legitimate responsibilities of doctors (and other health professionals).
Instead, let us be satisfied with the pragmatism of the DSM-IV.
Mental disorder. The DSM-IV admits that no definition adequately specifies precise
boundaries of the concept of mental disorder. However, due to imperative for a
definition, the following statement was achieved, In DSM-IV, each of the mental
disorders is conceptualized as a clinically significant behavioural or psychological
syndrome or pattern that occurs in an individual and that is associated with present
distress or disability or with a significantly increased risk of suffering death, pain,
disability, or an important loss of freedom. Acceptance of such definitions has been
universal, and accordingly, personality disorders can be considered mental disorders
and the legitimate target of doctors and other health professionals.
The explanation of why the mental disorders appear in DSM-IV on two separate axes
is also pragmatic. It is stated that this arrangement is to ensure that personality
disorders are no overlooked. The so-called Axis I disorders are usually more florid
and may obscure important aspects of personality. The DSM-IV continues, The
coding of Personality Disorders on Axis II should not be taken to imply that their
pathogenesis or range of appropriate treatment is fundamentally different from that
for the disorders coded on Axis I.

Diagnostic criteria
Cluster

Subtype

Discriminating features

A Odd/eccentric

Paranoid
Suspicious
Schizoid
Socially indifferent
Schizotypal Eccentric

B Erratic/impulsive Antisocial
Borderline
Histrionic
Narcissistic

Disagreeable
Unstable
Attention seeking
Self-cantered

C Anxious/fearful

Inhibited
Submissive
Perfectionistic

Avoidant
Dependent
Obsessive

Table. Clusters of personality disorder, adapted from DSM-IV-TR (American

Psychiatric Association, 2000)

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DSM-IV groups the personality disorders into three clusters, based on descriptive
similarities (Table)
The student should at first identify the appropriate Cluster. The precise diagnosis is
less important. DSM-IV criteria are of each personality disorder listed below.
Students will have greatest exposure to people with Cluster B personality disorder, as
they are far more likely than those in Cluster A and C to present at Emergency
Departments and to be admitted to public hospitals.

Cluster A Individuals appear odd or eccentric

Paranoid
Pervasive distrust and suspiciousness of others such that their motives are interpreted
as malevolent, beginning by early adulthood and present in a variety of contexts.
There must be at least 4 of the following:
Suspects, without sufficient basis, that others are exploiting, harming, or
deceiving
Preoccupied with unjustified doubts about the loyalty or trustworthiness of
friends or associates
Reluctance to confide in others
Reads hidden demeaning or threatening meanings into benign remarks
Persistently bears grudges (unforgiving of insults or slights)
Perceives attacks on his/her character or reputation which are not perceived by
others
Recurrent unjustified suspicions regarding fidelity of spouse or partners
Prevalence rate in the general population is 0.25-0.5%. Prevalence rate in psychiatric
inpatient units is 10-30%. Increased prevalence in the families of people with
schizophrenia and delusional disorder.

Schizoid
There is a pervasive pattern of detachment from social relationships and a restricted
range of expression of emotions in interpersonal settings, beginning by early
adulthood and present in a variety of contexts. There must be at least four of the
following:
Indifference to praise or criticism
Preference for solitary activities and fantasy
Lack of interest in sexual interactions
Lack of desire or pleasure in close relationships
Emotional coldness, detachment, or flattened affectivity
No close friends or confidants other than family members
Pleasure experienced in few, if any, activities
Prevalence estimates in the general population vary, may be as high as 7.5%.
Increased prevalence in the families of people with schizophrenia

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Schizotypal
There is a pervasive pattern of social and interpersonal deficits marked by acute
discomfort with, and reduced capacity for, close relationships as well as by cognitive
or perceptual distortions and eccentricities of behaviour, beginning by early adulthood
and present in a variety of contexts. There must be at least 5 of the following:
Ideas of reference (not delusions)
Odd beliefs and magical thinking (superstitiousness, beliefs in clairvoyance,
telepathy, etc)
Unusual perceptual disturbance (illusions, sensing the presence of nearby
people etc)
Paranoid ideation and suspiciousness
Odd, eccentric, peculiar behaviour
Lack of close friends, except family members
Odd thinking and speech without incoherence (vague, metaphorical etc)
Inappropriate or constricted affect
Social anxiety that does not diminish with familiarity and that is associated
with paranoid fears.
Prevalence rate in the general population is 3%. Increased prevalence in the families
of people with schizophrenia.

Cluster B Individuals appear erratic or impulsive

Antisocial
There is a pervasive pattern of disregard for and violation of the rights of others
occurring since the age of 15 years. The individual must be at least 18 years of age
and there must be evidence of conduct disorder before 15 years of age. There must be
at least 3 of the following:
Failure to conform to social norms (resulting in frequent arrests)
Deceitfulness, including lying and conning others for personal profit/pleasure
Recklessness, with disregard for the safety of self or others
Irresponsibility, failure to honour financial obligations or sustain work
Lack of remorse, indifference or rationalization of having hurt, mistreated or
stolen from others
Prevalence rate in the general population is 3% for men and 1% for women.
Increased prevalence in the families of people with antisocial personality disorder.
In the past, the terms antisocial personality and psychopath/psychopathic personality
disorder were used interchangeably. The modern approach, however, makes a
distinction. The antisocial individual is one who demonstrates antisocial behaviour of
the type listed above. The psychopathic individual demonstrates antisocial behaviour,
but in addition, demonstrates emotional impairment such as lack of guilt. Only 1/3 of
those with antisocial behaviour meet the criteria for psychopathy (Hart & Hare, 1996).
It is argued that the emotional impairment of individuals with psychopathy interferes
with socialization such that they do not learn to avoid antisocial behaviour.

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Borderline
A pervasive pattern of instability of interpersonal relationships, self-image, and
affects, and marked impulsivity beginning by early adulthood and present in a variety
of contexts. There must be at least 5 of the following:
Frantic efforts to avoid real or imagined abandonment
A pattern of unstable and intense interpersonal relationships characterized by
alternating between extremes of idealization and devaluation
Identity disturbance: markedly and persistently unstable self-image or sense of
self
Impulsivity in al least 2 areas that are potentially self-demanding (eg,
spending, sex, substance abuse, reckless driving, binge eating) (Illustration)
Recurrent suicidal behaviour, gestures or threats, or self-mutilation behaviour
(Illustration)
Affective instability due to a marked reactivity of mood (eg, intense episodic
dysphoria, irritability, or anxiety usually lasting a few hours and only rarely
more than a few days) (Illustration)
Chronic feeling of emptiness
Inappropriate, intense anger or difficulty controlling anger (eg, frequent
displays of temper, constant anger, recurrent physical fights) (Illustration)
Transient, stress-related paranoid ideation or severe dissociative symptoms.

Illustration. This is an entry from a note book maintained by an 18 year old female
with borderline personality disorder. She states she is feeling depressed. She is
referring to feelings of distress, rather than the experience of major depressive
disorder although the two are frequently confused by patients, their parents and
some doctors. She makes mention that when she cuts herself she feels good. Self
cutting is very common in people with borderline personality disorder it serves as a
means of releasing tension/distress. She uses a code IWIWD (I wish I was dead). She
makes this statement without clear conviction people with borderline personality
disorder frequently engage in suicidal behaviour (this is in addition to the cutting,
most of which has little to do with suicide, and as mentioned, is a means of releasing
tension/distress).

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Illustration. A further abstract from the note book mentioned above. The patient was
waiting at a bus stop with some people she knew when (she cannot remember why)
she began to have negative thoughts. Then I cut myself in front of everyone.
Naturally people tried to stop her this made her angry and threw things around and
kicked things. Dramatic, care eliciting, manipulative behaviour and unreasonable
anger are common features of borderline personality disorder.

Illustration. The arm of a man with a history of cutting. This man did not satisfy the
diagnostic criteria of borderline personality disorder. However, there were borderline,
histrionic and narcissistic traits, and he occasionally of cut himself when he was
distressed.

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Illustration. The arms, hands and abdomen of a man with a history of cutting. This
man satisfied the diagnostic criteria of borderline personality disorder. He kept the
large lesion on his left arm permanently open. The edges and even the base of the
lesion were scarred an indurated. He burnt the dorsum of his right hand and there was
muscle tissue loss from the extensors of his right forearm. There were less obvious (in
these photographs) scars on the upper chest. In the past he had swallowed razor
blades, which had perforated his bowel, leading to abdominal surgery. This man
repeatedly removed the stiches and recut his abdominal scar leading to a large
incisional hernia. (The bulging in the middle of his abdomen is abdominal organs
pushing out against the skin, the muscle wall of his abdomen having been damaged
through the repeated self cutting.)

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Prevalence rates are 2% in the general population, and 20% in psychiatric inpatient
populations. Childhood abuse is frequently reported. There is an increased prevalence
in the families of people with borderline personality disorder.

Histrionic
A pervasive pattern of excessive emotionality and attention seeking, beginning by
early adulthood and present in a variety of contexts. There must be at least 5 of the
following:
Is uncomfortable in situations in which he/she is not the centre of attention
Inappropriate sexually seductive or provocative behaviour
Displays rapidly shifting and shallow expressions of emotions
Consistently uses physical appearance to draw attention to self
Has a style of speech that is excessively impressionistic and lacking in detail
Shows self-dramatization, theatricality, exaggerated expressions of emotion
Is suggestible, ie, easily influenced by others or circumstances
Considers relationships to be more intimate that they actually are
Prevalence rates are 2-3% in the general population, and 10-15% in psychiatric
inpatient populations. Tends to run in families. A genetic link between histrionic and
antisocial personality disorder and alcoholism has been suggested.

Narcissistic
A pervasive pattern of grandiosity (in fantasy or behaviour), need for admiration, and
lack of empathy, beginning by early adulthood and present in a variety of contexts.
There must be at least 5 of the following:
Has a grandiose sense of self-importance (eg, exaggerates achievements and
talents, expects to be recognized as superior without achievements)
Is preoccupied with fantasies of unlimited success, power, brilliance, beauty,
or ideal love
Believes he/she is special and unique and can only be understood by, or
should associate with , other special or high-status people (or institutions)
Requires excessive admiration
Has a sense of entitlement, ie, unreasonable expectations of especially
favourable treatment or automatic compliance with his/her expectations
Is interpersonally exploitative, ie, takes advantage of others
Lacks empathy
Is often envious of others or believes that others are envious of him/her
Arrogant, haughty behaviours or attitudes
Prevalence rates are 1% in the general population, and 2-16% in clinical population.
Illustration.

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Illustration. The leading story of a regional newspaper told that a state branch of the
Royal Society for the Protection and Care of Animals (RSPCA) had lost millions of
dollars in donations due, in part, to the repeated lying of the CEO.
In his response the CEO wrote, I am a very moral and ethical person and feel
incredible shame that this happenedI admit freely the lies I told
It is often impossible to obtain a complete understanding of events from newspaper
reports. But the reader finds it difficult to comprehend how a person in a position of
responsibility could admit to telling lies, but at the same time maintain that, I am a
very moral and ethical person. One explanation would be that the individual is
narcissistic and thinks well of himself in spite of evidence to the contrary.

Cluster C Individuals appear anxious or fearful

Avoidant
A pervasive pattern of social inhibition, feelings of inadequacy, and hypersensitivity
to negative evaluation, beginning by early adulthood and present in a variety of
contexts. There must be at least 4 of the following:
Avoids occupational activities that involve significant interpersonal contact,
because of fears of criticism, disapproval, or rejection
Is unwilling to get involved with people unless certain of being liked
Shows restraint within intimate relationships because of the fear of being
shamed or ridiculed
Is preoccupied with being criticized or rejected in social situations
Is inhibited in new interpersonal situations because of feelings of inadequacy
Views self as socially inept, personally unappealing, or inferior to others
Is unusually reluctant to take personal risks or to engage in any new activities
because they may prove embarrassing
Prevalence rates are 0.5-1% in the general population, and 10% in psychiatric
outpatients.

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Dependent
A pervasive and excessive need to be taken care of that leads to submissive and
clinging behaviour and fears of separation, beginning by early adulthood and present
in a variety of contexts. There must be at least 5 of the following:
Has difficulty making everyday decisions without an excessive amount of
advice and reassurance from others
Needs others to assume responsibility for most major areas of his/her life
Has difficulty expressing disagreement with others because of fear of loss of
support or approval
Lack of initiative
Goes to excessive lengths to obtain nurturance and support form others
Feels uncomfortable or helpless when alone because of exaggerated fears of
being unable to care for him/her self
Urgently seeks another relationship as a source of care and support when a
close relationship ends
Unrealistically preoccupied with fears of being left to take care of him/herself
May be the most common personality disorder. There is no known familial pattern.

Obsessive-compulsive
A pervasive pattern of preoccupation with orderliness, perfectionism, and mental and
interpersonal control, at the expense of flexibility, openness, and efficiency, beginning
by early adulthood and present in a variety of contexts. There must be at least 4 of the
following:
Preoccupation with details, rules, lists, order, organization or schedules to the
extent that the major point of the activity is lost
Perfectionism that interferes with task completion
Over conscientiousness, scrupulousness, and inflexible about matters of
morality, ethics, or values.
Unable to discard worn-out or worthless objects even if they have no
sentimental value
Reluctant to delegate tasks or to work with others unless they submit to
exactly his/her way of doing things
Adopts a miserly spending style toward both self and others; money is viewed
as something to be hoarded for future catastrophes
Shows rigidity and stubbornness
Prevalence rates are 1% in the general population, and 3-10% in psychiatric
outpatients. There is an increased risk of major depressive disorder and anxiety
disorder, but for evidence for increased risk of OCD has not been established.

Neuroimaging in personality disorder

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While the personality disorders have been arranged in 3 clusters on the basis of
descriptive/clinical similarities, there is much heterogeneity, even within clusters.
Neuroimaging in personality disorders is at an early stage of development.
Psychopathic personality
Neuroimaging in psychopathic personality disorder has been reviewed (Pridmore et
al, 2005). Structural studies have reported decreased prefrontal grey matter, decreased
posterior hippocampal volume and increased callosal white matter, but to this point,
these studies have not been confirmed. Functional studies suggest reduced perfusion
and metabolism in the frontal and temporal lobes.
Two recent studies are of interest. Kiehl et al (2001) used fMRI and reported
increased activity in the frontotemporal cortex when criminal psychopaths were
dealing with emotional material (words). This was interpreted as evidence that
psychopaths required to exert additional effort to deal with emotional material. The
same group (Kiehl et al, 2004) then reported criminals failed to show a difference in
activation of the right anterior temporal gyrus when processing abstract and concrete
words. This was consistent with the researchers proposition that psychopathy is
associated with dysfunction of the right hemisphere during the processing of abstract
material. They speculated that complex social emotions such as love, empathy and
guilt may call for abstract functioning, and that abstract processing deficits based in
the right temporal lobe, may be a fundamental abnormality in psychopathy. These
studies have not been replicated.
Blair (2003), however, argues that the neural basis of psychopathy is malfunction of
the amygdala and connections to the orbitofrontal cortex.
To feel the excitement of current imaging, consider the work of Yang et al (2005).
These researchers compared the frontal lobes of three groups, 1) liars, 2) psychopaths
(selected to exclude marked lying behaviour) and 3) normal controls. They found liars
showed a 22-26% increase in prefrontal white matter and a 36-42% reduction in
prefrontal grey/white ratios, compared to the psychopaths and normal controls. This
study has not been replicated.

Borderline personality disorder

Imaging studies demonstrate biological differences between people with BPD and
healthy controls. See Lis et al (2007) for a detailed review. MRI studies demonstrate
bilateral reduced volume of the frontal lobes, hippocampus and amygdala, and
increased volume of the putamen. There are also reports of abnormalities of the
cingulated cortex. Magnetic Resonance Imaging (MRI) reveals N-acetyl-aspartate
(NAA) concentrations are reduced in the dorsolateral prefrontal cortex, suggesting a
lower density of neurons and disturbed neuronal metabolism. These anatomical
studies are consistent with functional imaging finding. Positron emission (PET)
studies generally demonstrate low metabolism in regions of the frontal cortex, basal
ganglia, thalamus, hippocampus and posterior cingulate. Some studies have shown
hypermetabolism in the anterior cingulated gyrus, and other structures. These data are
consistent with the theory that the areas of the brain which regulate and control
emotions are underactive, while the limbic structures may become overactive. If

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substantiated, these observations may help to explain the failure of rational thought to
control emotions and behaviour.

Others
Schizotypal personality disorder attracts research attention because of the clinical
similarities and genetic links with schizophrenia. Observations have included 1)
significantly reduced left and right caudate volumes, 2) altered frontotemporal
connectivity, 3) temporal lobe and basal striatal-thalamic dysfunction, and 4) reduced
superior temporal gyrus volume in those with thought disorder but not in those
without thought disorder. Consensus has not been reached.

Genetics
As the personality disorders are a heterogenous collection, the genetics of each will
probably be different. This field is developing. Antisocial personality disorder has
perhaps received the most attention. Rhee and Waldmann (2002) conducted a metaanalysis of 51 twin and adoption studies and found additive genetic influences (0.32),
non-additive genetic influences (0.09), shared environmental influences (0.16) and
non-shared environmental influences (0.43). Thus, both genetic and environmental
factors are important.
There appears to be a genetic basis for co-morbidity of novelty-seeking, antisocial
behaviour and susceptibility to substance dependence.
Allelic variations of monoamine oxidase A (MAOA) activity appear to contribute
modestly to the balance of hyperactive (impulsive-aggressive) and hypoactive
(anxious-depressive) traits (Jacob et al, 2005).
There is an increased prevalence of schizotypal personality disorder in the families of
people with schizophrenia. This appears to be based on genetic factors. While
temporal volume reductions have been reported in both people with schizotypal
personality disorder and people with schizophrenia, there may be preservation of
frontal lobe volume in people with schizotypal personality disorder (Siever & Davis,
2004).
There appears to be a strong genetic component for the development of borderline
personality disorder. There is a strong genetic influence on the traits which underlie
this disorder, such as neuroticism, impulsivity, anxiousness, affective instability, and
insecure attachment (Skodol et al, 2002). Borderline personality has been seen as a
variant of psychosis, posttraumatic stress disorder and bipolar disorder, but a clear
relationship has been demonstrated.

Aetiology
In common with the majority of psychiatric disorders, the aetiology of personality
disorders is believed to be multifactorial and involve genetic, intrauterine, early life
experiences and precipitating and perpetuating factors.

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17

Genetic factors have been mentioned above. Temperament refers to the bodys biases
in the modulation of conditioned behavioural responses to physical stimuli.
Temperament is not entirely due to genetic factors, but can be observed in babies
from birth. Temperament has a large influence on the childs interaction with others
(parents). A mismatch between the temperament of the child and the parents makes
for a difficult relationship, and this may predispose to the development of behavioural
and personality disorders.
Prenatal factors including hormone and alcohol exposure, and intrauterine nutrition,
and birth complications such as hypoxia, can be expected to impact on the
personality.
Early life experiences, particularly the quality of the parent child relationships
strongly influence personality development. Child abuse in all forms, particularly
sexual abuse, has deleterious effects, and may be associated with the development of
borderline personality disorder.
By definition personality disorders are lifelong, thus the concept of precipitating
factors may be synonymous with early life experience. However, personality disorder
may only become apparent with the loss of an important support, such as caring
parent, or when the individual is exposed to additional stress, such the responsibility
for the care of a new baby.
Perpetuating factors include the individuals habitual manner of responding. That is,
illegal drug use, aggressive outbursts, and inappropriate sexual provocation, for
example, are likely to damage relationships and lead to loss and distress. The
individual with a personality disorder has limited ability to deal with stress in an
adaptive manner, thus, a self-reinforcing maladaptive cycle emerges.

Management
Management begins with a full assessment and the exclusion of other psychiatric
disorders such as major depression. Comorbid conditions should managed in the
standard manner.
Treatment depends on the nature of the nature of the personality disorder, patient
willingness to engage in treatment and the available resources (availability of
specialist psychotherapists and treatment programs).
Personality disorder is often regarded as resistant to psychiatric treatment and limited
treatment is offered. This is an unduly pessimistic attitude, as relief and personal
growth can occur. However, prolonged treatment may be necessary and complete
recovery is the exception rather than the rule. Individuals with antisocial personality
disorder may be unable to enter into a therapeutic relationship and are generally
regarded as untreatable in all but specialized (usually forensic) units.
Psychotherapy is the primary treatment. This may take many forms. Dynamic
psychotherapy (with roots in Freudian analysis) and cognitive behaviour therapy

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18

(which is focused more on thinking processes and behaviour) both have much to
offer. Supportive psychotherapy, in which the therapist mainly supports, educates and
encourages the patient through the trials of life buys time and fosters the growing
process. Psychotherapy may be conducted as individual or group sessions. In
specialized practice the patient may attend both.
Medication may have a place in the management of specific symptoms.
Antidepressants (such as fluoxetine) have a place in relieving anxiety and distress,
even in the absence of full major depressive disorder. The benzodiazepines are best
avoided because to the potential for addiction. Irritability may be helped by a trial of a
mood stabilizer (such as sodium valproate) or an antipsychotic (such as low dose
chlorpromazine).
It is important to involve the family (with the permission of the patient). A clear
explanation at an early stage, of the diagnosis, the difficulties experienced by the
patient and the clinician, and the likely prognosis, will be of assistance to all involved.
The management of people with borderline personality presents special challenges.
These people are usually angry much of the time and can move from happy to
unhappy in response to minor events. They are particularly inclined to self-mutilation
(cutting) and suicidal behaviour. Many people with borderline personality disorder
have a limited ability to understand and describe the way they are feeling; they are
limited to feeling good/happy or bad/distressed/tense/angry. They have limited ability
to deal with their bad/distressed/tense/angry state. When they are in this unwelcome
state they frequently get relief from cutting themselves. They report feeling a sense of
great relief when blood flows out. Such cutting can be distinguished from attention
seeking behaviour (although some subsequent attention may also be rewarding) and
the intention to die. However, suicide may be attempted and may be successful.
People with borderline personality (as with people with other personality disorders)
are best managed in the community with the help of an experienced
psychotherapist/counsellor. It is better for them to live in the real world and learn to
deal with the challenges which the real world presents. However, admission to
hospital for a brief time (2-3 days) may be indicated when they are in the grip of the
bad/distressed/tense/angry state. Such admissions are for safety purposes only. Being
in hospital for long periods increases dependency and a sense of impotence and
failure. Hospital is an artificial environment with little opportunity for the growth of a
sense of autonomy and competence. The best outcome may be achieved where the
patient, an out-patient psychotherapist and a psychiatric inpatient unit cooperate in
formulating a plan of regular out-patient psychotherapy and easy admission and rapid
discharge (no inpatient psychotherapy) at times of crisis.

Prognosis
The prognosis depends on the nature and severity of the personality disorder. Cluster
B disorders, characterized by erratic and impulsive behaviour usually improve with
age (after 35 years). These people (as with the rest of us) mature over time and
become less volatile, violent and irritable. Cluster C disorders, characterized by

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19

anxious and fearful disposition tend to become more confident and assertive. Cluster
A disorders, characterized by eccentricity may not change markedly.
Management as detailed above may prove helpful.
Suicide may occur. Some estimates are that people with severe borderline personality
with comorbid substance abuse has a 50% lifetime risk of suicide. However, as stated,
maturation brings improvement and if these people stay alive, the risk of suicide
eventually declines.

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