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Pathophysiology Acute Pyelonephritis

Acute pyelonephritis is caused by bacteria entering the urinary tract and kidneys, often due to obstruction, vesicoureteral reflux, pregnancy, or instrumentation. Predisposing factors include gender, age, lifestyle, and medical conditions. Bacteria travel through the urethra and bladder to the kidneys, causing inflammation of the renal tissue, abscesses, and necrosis. Symptoms include fever, pain, and dysuria. The infection can lead to renal failure if not treated.

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2K views2 pages

Pathophysiology Acute Pyelonephritis

Acute pyelonephritis is caused by bacteria entering the urinary tract and kidneys, often due to obstruction, vesicoureteral reflux, pregnancy, or instrumentation. Predisposing factors include gender, age, lifestyle, and medical conditions. Bacteria travel through the urethra and bladder to the kidneys, causing inflammation of the renal tissue, abscesses, and necrosis. Symptoms include fever, pain, and dysuria. The infection can lead to renal failure if not treated.

Uploaded by

Anonymous 75TDy2y
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Pathophysiology Acute Pyelonephritis

Precipitating Factors
Obstruction of urinary outflow, Vesicoureteral Reflux,
Neurogenic Bladder, Renal Diseases, Metabolic Disturbances
Predisposing Factors
Gender, Older Age, Lifestyle, Environment,
Pregnancy, Instrumentation, Chronic Analgesic Abuse

Bacteria gain access to blood


Intestinal
M.O.
Systematic Arteries

Exegenous
M.O.

Genitor-Urinary
M.O.

Urethra

Systematic Circulation

Ureters and Bladder

Kidneys
Inflammation of the renal
tissue
Increase WBC and Platelet Small abscess in
the calyx surfaces

Fever,
FeverPain

Infection

Suppuration
Change of abscess to lesions
(Pus Formation)

Pain and bladder retention

Pain and Pyuria

Increase polymorphnuclea
leukocytes in the tubules and
in the interstitium surrounding
the tubules
Bleeding in the mucous
membrane of the adjacent
collecting system
Destruction of
Necrosis of Renal Tissue
Segments of tubules

Leukocyte Casts May lead to Renal Failure


(Accumulation of WBC)

Dysuria

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