Functional
Functional
EDITION no 3-9)
12. Which of the following statements concerning vestibular causes off falls are true?
1. Patients with Meniere's disease may suddenly fall without accompanying vertigo
2. Aberrant signals from vesnbular receptors result in inappropriate postural
adjustment
3. Patients with vertigo can have gait ataxia and falls without appendicular ataxia
4. Peripheral vestibulopathy is the most likely cause ofcryptogenic falls in middleaged women
Select A =1,2,3. B= 1,3. c= 2, 4. D =4 only. E= All
(Jawab:A REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 3-10)
13. Drop attacks may be exacerbated by carbamazepine in patients with Rolandic
epilepsy.
T. True
F. False
(Jawab:T REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 3-13)
14. Which of the following statements regarding depression in Parkinson's disease are true ?
1. Depression is a common accompaniment
2. Psychosis is common
3. Patients with major depression progress faster in PO than patients without depression
4. Depression in PD is more likely with
older age of onset of disease
Select: A; 1,2,:1. B; 1,3. C = 2,4. D =4 only. E= All
(Jawab:A REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 8-9)
Questions 15 through 17:
Behavioral alterations are common in epilepsy. For each behavioral state, select whether
the condition is more likely to be ictal, postictal, or interictal.
A. Ictal
B. Postictal
C. Interictal
D. Any of the above
15. Confusion.
(Jawab:B REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 8-13)
16. Depression.
A. Quinine'
B. Carbamazepine
C. Phenytoin
D. Albuterol
(Jawab:D REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 29-7)
44. Which of the following statements is true regarding neurogenic muscle cramps?
A. The cramps are due to electrical activity in the peripheral nerves but the muscle
fibers are electrically silent
B. Neurogenic muscle cramps always have their origin in the peripheral nerves
C. CNS lesions can produce muscle cramps
D. EMG in neurogenic muscle cramps shows repetitive discharge of individual
muscle fibers
(Jawab:C REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 29-8)
45. Which of the following is not true of chronic fatigue syndrome?
A. Patients report chronic muscle pain and fatigue
B. Sensory symptoms are absent
C. Central symptoms include headache and dizziness
D. Muscle biopsy shows non-inflammatory muscle fiber degeneration
(Jawab:B REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 29-9)
46. A 23-year-old man presents with pain and tenderness in the quadriceps. He climbed a
small mountain several days previously, but the pain did not develop until the next day.
Which is the most likely explanation?
A.Subclinical muscular dystrophy exacerbated by the exercise
B. Rhabdomyolysis from the untrained exertion
C. Delayed onset muscle soreness
D. Psychogenic pain due to the effort
(Jawab:C REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 29-10)
47. Which of the following are true regarding sensory function in trigeminal neuralgia'!
A. Sensory loss is confined to one trigeminal branch distribution
B. Sensory loss is episodic and not confined to the trigeminal distribution
C. Sensory loss can extend beyond the distnbution of the lancinating pain
D. Sensory loss is not expected, and when present suggests an alternative diagnosis
(Jawab:D REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 31-12)
48. Sexual dysfunction is common in patients with epilepsy, especially in patients with
complex partial seizures. Which of the following sexual dysfunctions are seen with
increased frequency in patients with epilepsy?
1.
2.
3.
4.
Hypersexuality
Decreased sexual interest
Erectile dysfunction
Fetishism
Select: A = 1.2.3. B = t. 3. C = 2,4. D - 4 ooly. E = All
(Jawab:E REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 32-3)
53. A 54-year-old man presents with pain in the right arm which is centered near the shoulder.
There is some radiation into the upper arm but not into the lower arm or hand. There is no
motor or reflex abnormality. Manipulation of the shoulder reproduces and exacerbates the
pain. Which is the most likely diagnosis?
A. Brachial plexus injury
B. Musculocutaneous nerve injury
C. Axillary nerve injury
D. Primary shoulder pathology
(Jawab:D REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 33-3)
54. Which of the following are features of carpal tunnel syndrome?
1. Predisposition by diabetes and other causes of neuropathy
2. Loss of sensation on the thenar eminence
3. Atrophy and weakness of the abductor pollicis brevis
4. Denervation is seen in the first dorsal interosseus
Select: A = 1,2,3. B = 1, 3. C = 2, 4. D = 4 only. E = All
(Jawab: B REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE
4TH EDITION no 33-6)
55. Lesion of the posterior interosseus nerve would produce which of the following?
1. Denervation of the finger and thumb
2. extensors denervation of the extensor carpi radialis longus
3. Denervation of the extensor carpi radialis brevis
4. Denervation of the triceps
Select: A = 1,2,3. B = 1, 3. C = 2, 4. D =4 only. E = All
(Jawab:B REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 33-7)
56. Which of the following muscles is supplied by the superficial peroneal nerve?
A. Tibialis anterior
B. Vastus medialis
C. Medial gastrocnemius
D. Soleus
E. None of these
Jawab:E REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 34-1)
57. You are asked to consult on an 80-year-old man with right leg weakness. He is status-post
partial colon resection and has had a slow recovery, with bed rest for more than a week
with little ambulation. The weakness developed three days ago. Examination shows
weakness of the right tibialis anterior but other muscles are of normal strength. Reflexes
are slightly depressed at the ankle but otherwise normal. Which is the most likely
diagnosis?
A. Peroneal neuropathy
B. Lumbar radiculopathy
C. Retroperitoneal hematoma
D. Retroperitoneal abscess
Jawab:A REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 34-11)
Questions 58 through 60:
The following questions concern patients with dementia. For each, select the most likely
diagnosis from the following list.
A. Alzheimer's disease
B. Hydrocephalus
C. Creutzfeldt jakob disease
D. Vascular dementia
58.
(Jawab:C REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 36A-8)
59. Normal EEG background with 8.5 Hz posterior dominant rhythm.
(Jawab:A REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 36A-9)
60. Focal slowing is seen in the right occipital region with loss of the posterior dominant
alpha. Also, there is slowing in the right temporal and bilateral frontal regions.
(Jawab:D REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 36A-10)
61. The Manin-Gruber anastomosis is an important anomaly in the innervation of muscles of
the hand which affects nerve conduction study results. Which of the following
summarizes the anastomosis findings when testing ulnar nerve conduction?
A. Sensory nerve action potential amplitude is greater with distal than proximal
stimulation
B. Sensory nerve action potential amplitude is greater with proximal than distal
stimulation
C. Motor conduction measuring abductor digiti minimi CMAP shows greater
amplitude with distal stimulation than proximal stimulation
D. Motor conduction measuring abductor digiti minimi CMAP shows greater
amplitude with proximal stimulation than distal stimulation
(Jawab:C REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 36B-1)
66. The figure shows FOG-PET of a patient with a history of malignant tumor in the left
posterior temporal region status post radiation therapy. What conclusion can be made on
the basis of the data?
A. Radiation necrosis
B. Recurrent tumor
C. Infarction in the region of the previous tumor
D. Study is not conclusive
(Jawab:B REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 37E-5)
67. Which of the following statements are true regarding mild cognitive impairment?
1. MCI is a normal accompaniment to aging
2. MCI cannot be arrested with current medications
3. All patients with MCI progress to AD
4. Impairment in cognitive performance other than memory predicts decline in patients with
MCI
Select: A = 1.2, 3. B = I, 3. C = 2. 4. D = 4 only. E = All
(Jawab:C REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 38-1)
68. Which of the following statements is true regarding neuropsychological changes in
Parkinson's disease?
A. Cognitive deficits develop in 30% of Patient with PD
B. Dementia develops in the majority of patients with PD
C. Cognitive deficits are present in the majority of patients with PD
D. Cholinesterase inhibitors have no effect on the treatment of AD
(Jawab:D REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 38-1)
69. What effect does epilepsy have on mortality rates?
A. No change in mortality
B. Higher mortality mainly due to motor vehicle accidents
C. Higher mortality due to multiple causes
D. Lower mortality since they have ongoing medical care
(Jawab:C REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 43-4)
70. Which is the most common cause of epilepsy in the world?
A. Trauma
B. Genetic inheritance
C. Benign tumor
D. Neurocysticercosis
(Jawab:D REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 43-5)
71. Which of the following statements are true regarding epidemiology of epilepsy?
1. Seizures are more likely at the extremes of age, in infancy and with advanced age
2. Myoclonic seizures are most common in infancy
3. Absence seizures do not begin after young adult life
4. Simple partial seizures peak in middle age
Select: A = 1.2.3. B = 1.3. C = 2. 4. D = 4 only. E = All
(Jawab:E REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 43-9)
72. What is the role of rehabilitation and physical activity for patients with
Parkinson'sdisease?
A. No benefit has been demonstrated
B. Self-guided exercise is encouraged, but formal rehabilitative training is not of
benefit
C. Rehab and exercise produces benefits which outlast the duration of the activity
D. Rehab and exercise produce benefits which are lost without continued activity
(Jawab:D REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 54-10)
73. Which of the following types of peripheral nerves are most sensitive to traumatic injury?
A. Large-diameter myelinated axons
B. Small-diameter myelinated axons
C. Unmyelinated axons
D. There is no substantial difference
(Jawab:A REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 56D-1)
74. Segmental demyelination of a peripheral nerve suggests which type of injury?
A. Compression
B. Penetrating injury
C. Ischemic damage
D. Toxic damage
(Jawab:A REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 56D-2)
75. An infant presents to you with Erb's palsy with damage to the upper brachial plexus. How
would you advise the parents of the injury and prognosis?
A. The damage is from stretch and damage to the myelin sheath, and prognosis is
excellent
B. The damage is mainly to the axons from stretch, and prognosis is variable and too
soon to predict
C. The damage is to both the axons and myelin sheath, and prognosis for recovery is
poor
(Jawab:B REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4 TH
EDITION no 56D-3)
76. A heroin addict presents with left median neuropathy secondary to repeated injection into
the fore&rm. He never bad an injection directly into the nerve that he remembers, but has
had gradual progressive loss of left median nerve function. Examination shows the
proximal forearm near the antecubital fossa to be fibrotic. Which is appropriate
treatment?
A. Analgesics
B. Corticosteroids
C. Surgical intervention in the foreann
D. Surgery at the carpal tunnel
(Jawab:C REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 56D-4)
77. A child with severe epilepsy is placed on a ketogenic diet which results in some
improvement of control of the seizures. She subsequently develops visual loss and is
found to have optic neuropathy. What is the most likely cause?
A. Mass lesion causing seizures and optic nerve compression
B. Vitamin A deficiency
C. Thiamine deficiency
D. Nicotinic acid deficiency
(Jawab:C REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 63-3)
78. Which of the following suggest striatonigral degeneration rather than Parkinson's
disease?
1. Absence of resting tremor
2. Asymmetric motor signs
3. Severe autonomic dysfunction
4. Slower functional decline
Select: A = 2, 2, 3. B = I. 3. C = 2.4. D = 4 only. E = All
(Jawab:B REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 72-9)
79. A patient presents with episodes of unresponsiveness without loss of postural tone. He
appears unaware of external stimuli during the episode and briefly confused after the
episode. He has no memory for events during the episode. Which is the most likely
diagnosis?
A. Attention deficit disorder
B. Absence seizure
C. Simple partial seizure
84. MRI images of a patient with complex partial seizures are shown in the figure. Top is T
1-weighted and bottom is T2-weighted imaging.
96. A 68-year-old man presents with severe shoulder pain which radiates into the neck., upper
chest, and into the medial aspect of the upper arm. He has weakness of the median and
ulnar-innervated intrinsic muscles of the hand. Which of the following are reasonable
differential diagnoses of this pain?
1. Carpal tunnel syndrome
2. Cervical radiculopathy
3. Monomelic amyotrophy
4. Brachial plexopathy
Select: A = 1,2,3. B = 1,3. C = 2, 4. D = 4 only. E = All
(Jawab:D REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 81-9)
97. A 23-year-old female presents with 3 weeks of weakness most prominent distally,
dysesthesias and paresthesias. Examination is most remarkable for areflexia. Which is the
most likely diagnosis?
A. Acute inflammatory demyelinating polyradiculoneuropathy
B. Chronic inflammatory demyelinating polyradiculoneuropathy
C. Tick paralysis
D. Porphyria
(Jawab:A REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 82-1)
98. A patient with carpal tunnel syndrome has marked increase in symptoms during
pregnancy. She already has tried wrist splints. Examination shows marked weakness of
the abductor pollicis brevis muscle. Which is the next best approach to treatment?
A. Anti-inflammatory treatment and continued use of wrist splints
B. Corticosteroid injection into the carpal tunnel
C. Corticosteroids by systemic administration
D. Endoscopic surgery
(Jawab:D REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 87-2)
99. Which of the following statements is true regarding pregnancy and epilepsy?
1. AEDs increase the risk of birth defects
2. The greatest risk of birth defects is from exposure to AEDs io the first trimester
3. Folate supplementation prior to and during early gestation reduces the incidence of birth
defects
4. About 90% of epileptic women deliver nonnal babies
Select: A = 1.2.3. B = 1.3. C= 2.4. D= 4 only. E= All
(Jawab:E REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 87-6)
100. A woman with complex partial seizures with secondary generalization is
contemplating pregnancy. The combination ofvalproate and oxcarbazepine completely
controls the seizures. You advise her about folate supplementation. How would you
advise her regarding medication management for the seizures?
A. Since she has good seizure control, the combination should be maintained
B. Monotherapy with OXC should be tried before becoming pregnant
C. Monotherapy with VPA should be tried before becoming pregnant
(Jawab:B REVIEW MANUAL FOR NEUROLOGY IN CLINICAL PRACTICE 4TH
EDITION no 87-7)
101. Wanita 30 tahun datang dengan nyeri di wajah yg dimulai sebulan lalu dengan rasa
aneh pada wajah.yang diikuti dengan sensasi tersengat listrik menjalar dari rahang hingga
mata kanan, seminggu kemudian merasakan hal yg sama disisi kiri .kadang bersamaan
dgn sisi yg kanan. Ia minum karbamazepin 600 mg/hari oleh dokter yg merujuknya untuk
kontrol nyeri. Pemeriksaan fisiknya dalam batas normal kecuali kelemahan pada lengan
dan kaki kiri. Pemeriksaan yg anda jalankan sebgai berikut kecuali:
a. MRI dengan dan tanpa kontras
b. EEG
c. Lab darah lengkap
d. Tes psikologis
e. Kadar karbamazepin serum
(Jawab : B, SANS V Nomor 11.)
102. Wanita 38 tahun penderita tekanan darah tinggi mengalami infark kapsula interna
kanan dan thalamus. Hal ini menyebabkan hemiparesis bermakana dan rasa tebal pada
sisi kiri tubuh. Segera setelah itu, timbul nyeri berat di lengan kiri, tungkai dan wajah.
Obat-obatan tidak mampu menangani nyeri tersebut. Prosedur operasi untuk menangani
sindroma nyeri thalamus adalah
a. implant alat intratechal drug delivery
b. topectomi frontal, cortekstomy parietal, atau cingulotomi
c. thalamotomi stereotaktik
d. deep brain stimulation
e. semua di atas benar
(Jawab : E, SANS V Nomor 38.)
Untuk pertanyaan 103-106 pilih jawaban dari kemungkinan di bawah
B. neuropraxia
C. axonotmesis
D. keduanya
E. bukan keduanya
103. membutuhkan regenerasi sel saraf untuk mengembalikan fungsinya
SANS V Nomor 62.)
104.
105.
(Jawab : B,
106. stabilisasi luka dengan transeksi anatomi komplit pada nerve (Jawab : D, SANS V
Nomor 65. )
muntah yang menyertai nyeri kepala tetapi pasien terkadang mengalami fotofopia ringan.
Aktifitas sehari-hari seperti naik tangga, tidak memperparah nyeri kepalanya. Pasien
biasanya akan membatalkan kegiatannya jika sedang sakit kepala. Menurut International
Headache Society Classification 1988, diagnosa yang paling tepat untuk nyeri kepala ini
adalah:
a. cluster headache
b. Tension type headache episodik
c. Cluster migraine
d. Common migraine
e. Tension type headache
(Jawab : B, SANS V Nomor 125.)
111.
112.
113.
Sindroma epilepsy lobus mesial temporalis berhubungan dengan hal berikut kecuali
a. Patologi yang paling sering ditemukan pada reseksi lobus temporalis
adalah hilangnya neuron hipokampus berat, disebut sclerosis
hipokampus
b. Sclerosis hipokampus terdiri dari hilangya neuron yang terberat di CA2
yang teringan di CA1(Sommers sector)
c. Reorganisasi sinaptik dari mossy fiber granule cell adalah gambaran
patologis yang berhubungan dengan sclerosis hipokampus
d. Kemungkinan berhasil paling baik dalam menghentikan kejang adalah
jika patologi fokal ditemukan di specimen temporal
(Jawab : B, Sans VI Nomor )
114. Berdasar pemeriksaan patologi klinis dari pasien dengan epilepsy lobus temporalis,
patogenesis sclerosis hipokampal yang paling mungkin
a. Selalu dimulai sebagai akibat kejang awal (c/ kejang demam, status
epileptikus)
b. Terjadi hanya pada kejang masa kecil
c. Membutuhkan cedera otak awal seperti status epileptikus dan atau
iskemi dan bukan merupakan konsekuensi dari epilepsy lobus temporalis
berulang
d. Merupakan konsekuensi dari epilepsy lobus temporalis berulang
D. Pungsi lumbal
(Jawab : A, Sans VI Nomor 163. )
124. Ketika perempuan diatas berumur 5 tahun, pola EEG berubah dan serangan menjadi
medically intractable, terutama terdiri dari axial tonic seizures, atonic seizures, dan
atypical seizures. Mana terapi pembedahan yang direkomendasikan untuk pasien ini?
A. temporal lobectomy
B. hemispherectomy
C. Corpus callosotomy
D. thalamotomy
E. multiple subpial transection
(Jawab : C, Sans VI Nomor 179. )
125. Memaki dan vokalisasi nyaring pada saat kejang dan menendang serta marah sering
berhubungan dengan kejang yang berasal dari
a. Neokorteks frontal
b. Neokorteks parietal
c. Region limbic mesial basal
d. Neokorteks oksipital
e. Neokorteks temporal
(Jawab : A, Sans VI Nomor 193. )
126.
127.
thalamotomi stereotaktik paling sukses dalam penanganan pasien dystonia yang mana
a. dystonia trunkal
b. dystonia cervical
c. dystonia facial
d. dystonia tungkai kontralateral
e. dystonia tungkai ipsilateral
(Jawab : D, Sans VI Nomor 201. )
128.
129.
133.
The MOST common clinical feature of medial temporal lobe seizures is:
A. Visual aura.
B. Ictal Oral Automatism
C. Ictal bicycling movements
D. Ipsilateral dystonic posturing
(Jawab : B , SANS VII, Nomor 4.)
134.
C. Complex partial
D. Infantile Spasm
E. Atonic
(Jawab : D , SANS VII, Nomor 5.)
135.
136. Which of the following structures is BEST described as lateral to the hippocampal
complex (hippocampus, subiculum and parahippocampal gyrus)?
A. Brain stem.
B. Ambient cistern.
C. Posterior cerebral artery.
D. Fusiform gyrus
E. Occulomotor nerve
(Jawab : D , SANS VII, Nomor 7.)
137. During the creation of a burr hole for a deep brain stimulator, an awake, sedated
patient develops the sudden onset of coughing, hypotension, and hypoxia. The clinical
presentation suggest which of the following complications:
A. Intracranial hemorrhage
B. Aspiration pneumonia
C. Air embolism
D. Tension pneumocephalus
(Jawab : C , SANS VII, Nomor 2.)
138. The most sensitive method for detecting carpal tunnel syndrome is
A. needle examination of the abductor pollicis brevis
B. needle examination of the first and second lumbricals
C. motor amplitude of the median nerve
D. motor distal latency of the median nerve
E. palmar sensory conduction time of the median nerve
Jawab : E
(NBR 2nd Edition 2005 chapter I : Neurosurgery, no. 30)
139. In the treatment of chronic pain, the undesirable effect(s) that is/are more common in
stimulation of the periaqueductal gray than the periventricular gray region is/are
I.
diplopia
II.
oscillopsia
III.
reduction of upgaze
IV.
sense of impending doom
A. I, II, III
B. I, III
C. II, IV
D. IV
E. all of the above
Jawab : E
(NBR 2nd Edition 2005 chapter I : Neurosurgery, no. 57)
140.
141.
Donor nerves that may be used for neurotization after brachial plexus avulsion include
I.
intercostal nerves
II.
spinal accessory nerve
III.
cervical plexus
IV.
phrenic nerve
A. I, II, III
B. I, III
C. II, IV
D. IV
E. all ofthe above
Jawab : E
(NBR 2nd Edition 2005 chapter I : Neurosurgery, no. 196)
149. Sakit bahu yang parah yang beberapa harikemudian diikuti oleh lumpuh pada tangan
di sekitarnya merupakan ciri khas dari
A. Sindrom Erb-Duchene
B. Sindroma PARSONAGE-TURNER
C. Sindroma DEJERINE-KLUMPKE
D. Sindroma Benedict
E. Bukan salah satu dari A sampai dengan D
(Jawab: B, INBR 7 Chapter 3 no.120)
150. Ny. X, 62 tahun menjalani dekompresi mikrovaskuler karena spasme hemifasial.
Pasca-bedah, pasien menderita ketulian ipsilateral total tanpa adanya defisit neurologis
lainnya Penyebab yg paling memungkinkan dari defisit ini adalah cederanya salah satu
pembuluh darah berasal dari
A. Arteri serebral belakang (PCA)
B. Arteri serebelar Atas (SCA)
C. Arteri serebellar Inferior Anterior (AICA)
D. Arteri serebellar bawah belakang (PICA)
E. Arteri vertebral
(Jawab: C, INBR 7 Chapter Neurosurgery no.19)
151. Salah satu prosedur paling dini yang dilakukan untuk penyakit Parkinson adalah ligasi
pembuluh darah yang mana?
A. Arteri koroidal anterior
B. Arteri koroidal belakang tengah
C. Arteri balik Heubner
D. Arteri tentorial Bernasconi dan Cassarini
E. Arteri lentikulostriata media
(Jawab: A, INBR 7 Chapter Neurosurgery no.23)
152. Stimulasi saraf vagal dicadangkan untuk memilih pasien dengan epilepsi. Mengapa
dilakukannya pada sisi kiri?
A. Untuk menghindari kemungkinan cedera pada saraf laringeal balik, yang mengikui
jalur ke arah kanan yang lebah rawan kerusakan
B. Untuk menghindari kemungkinan rusaknya saraf laryngeal atas dominan di sisi kanan.
C. Untuk menghindari kemungkinan rusaknya saraf kranial X, yang memasok jantung
terutama dari sisi kanan
D. Untuk menghindari kemungkinan cedera pada saluran torak
E. Lebih kecil peluang terjadinya paralisis dan seraknya urat suara dari kiri
(Jawab: C, INBR 7 Chapter Neurosurgery no.24)
153. Perawatan manakah yang menjadi pilihan utama untuk luka avulsi pleksus brakial
kronis dan yang membandel?
A. Kordotomi
B. Lesioning Zona Entri Akar Dorsal (DREZ)
C. Penempatan pompa morfin
D. Mielotomi garis tengah
E. Stimulasi otak dalam talamik lateral ventroposterior (VPL)
(Jawab: B, INBR 7 Chapter Neurosurgery no.25)
(SOAL INBR 7 Chapter Neurosurgery no.154 160)
A. Kordotomi
B. Stimulasi gray periakueduktal
C. Elektrokauteri trigeminal prakutanus
D. Simpatektomi
E. Talamotomi bilateral
F. Palidotomi
G. Mielotoni komisural
154. Disartria dan penurunan kognitif
no.48)
Kutukan Ondine
157. Gangguan pergerakan mata, pupil dilatasi, rasa takut (Jawab: B, INBR 7 Chapter
Neurosurgery no.51)
158.
Sindroma HORNER
159.
Anestesia dolorosa
160. Lemah kaki, disestesia, disfungsi kandung Kemih (Jawab: G, INBR 7 Chapter
Neurosurgery no.54)
161.
B. Karsinoma metastatis 1-cm frontal kanan dan 2-cm parietal kiri dari paru-paru.
C. Glioblastoma kambuhan pada lobe temporal kiri (2 cm3)
D. Kavermoma 1-cm dari inti kaudatus kanan yang sebelumnya mengalami
perdarahan.
E. Malformasi Arteriovenus talamik bilateral ( 3 cm3)
(Jawab: D, INBR 7 Chapter Neurosurgery no.72 )
162. Semua hal di bawah ini akan menurunkan penyebaran rasa sakit atau reaksi pasien
terhadap rasa sakit, KECUALI
A. stimulasi gray periakueduktal
B. Lobotomi pra-frontal
C. Singulotomi
D. Hipokampektomi
E. Kordotomi ventrolatera
(Jawab: D, INBR 7 Chapter Neurosurgery no.73)
163. Terapi-terapi bedah yang digunakan untuk Distonia biasanya meliputi semua hal di
bawah ini, KECUALI
A. Denervasi periferal
B. Pallidotomi
C. Talamotomi
D. Stimulasi kolom dorsal
E. Stimulasi korteks motorik
(Jawab: E, INBR 7 Chapter Neurosurgery no.89)
164. Semua prosedur bedah di bawah ini telah dilakukan untuk merawat penyakit
neuropsikiatris dan gangguan-gangguan keperilakuan, KECUALI
A. Faskikulotomi arkuate
B. Traktotomi subkaudate
C. Leukotomi limbik
D. Kapsulotomi depan
E. Singulotomi depan
(Jawab: A, INBR 7 Chapter Neurosurgery no.90)
165. Tn X., 45 tahun memiliki riwayat panjang epilepsi dari foci kejang yang berawal dari
korteks pra-motorik kanan dan menjalar ke dalam korteks motorik di sekitarnya. Kejangkejangnya tetap refraktoris kepada berbagai obat antiepilepsi, dan pasien telah dirujuk
kepada akhli bedah saraf untuk membahas mengenai pilihan-pilihan pembedahan. Catatan
hasil EEG mengungkapkan fokus kejang pada daerah pra-motorik yang menjalar ke
korteks motorik di sekitarnya. prosedur-prosedur pembedahan manakah di antara
prosedur-prosedur di bawah ini yang dapat dilaksanakan secara berbarengan selama
lesionektomi untuk menghindari cedera berat atas korteks motorik dan membantu
mengendalikan kejang-kejang pada pasien?
A. Topektomi
B. Lesionektomi terbatas
C. Stimulasi korteks motorik
D. Transeksi subpial multiple
E. Stimulasi saraf vagal
(Jawab: D, INBR 7 Chapter Neurosurgery no.98)
166. Manakah yang merupakan komplikasi yang secara neurologi paling berkaitan setelah
penempatan stimulator saraf vagal?
A. Mati rasa pada wajah
B. Bradikardia
C. Disponia
D. Hipotensi
E. Aritmia dengan durasi pendek
(Jawab: C, INBR 7 Chapter Neurosurgery no.99)
167.
Matching. Regarding surgical
treatment of Parkinson disease and its historical background, match the listed
procedures with the appropriate phrase(s) and benefits: Abandoned because (1 )
unpredictable results; (2) tremor did not improve; (3) bradykinesia did not improve; (4)
rigidity did not improve; (5) ipsilateral tremor persists; (6) side effects/resistance; (7)
only modest benefits Procedure:
a anterior choroidal artery ligation (1)
b anterodorsal pall idotomy (2,3)
c ventrolateral thalamotomy (3,4,5)
d L-dopa (6)
e transplantation Procedure currently pallidotomy of globus pallidus interna (GPI)
Beneficial for the following (percentage) (7)
f.dyskinesia is 90%
g bradycardia is 85 %
h rigidity is 75%
i tremor is 57 %
(Greenberg 15. Functional Neurosurgery no. 1)
168. True or False. The following symptoms improve after anterodorsal pallidotomy:
a tremor ipsilateral false
b rigidity true
c bradykinesia false
d ataxia false
e tremor contralateral false
(Greenberg 15. Functional Neurosurgery no. 2)
169. Ventrolateral thalamotomy can improve tremor; it cannot be performed bilaterally
because bilateral thalamotomy causes:
a). dysarthria
b). gait disturbance (Postoperative dysarthria and gait disturbance incidence is high.
(Greenberg 15. Functional Neurosurgery no. 3)
170. Complete the following about surgical treatment of Parkinson disease:
a The target today is the posteroventral pallidum
b Specifically the GPi-internal segment of the globus pallidus Which blocks the input
from the STN-Subthalamic nucleus
(Greenberg 15. Functional Neurosurgery no. 4)
171.
progabide
(Greenberg 15. Functional Neurosurgery no. 17)
183. What are the nonablative procedures used for the treatment of spasticity?
intrathecal baclofen
intrathecal morphine
epidural electrical stimulation
(Greenberg 15. Functional Neurosurgery no. 18)
184. What are the ablative procedures with preservation of ambulation used for the
treatment of spasticity? Name one. motor point block, phenol nerve block, selective
neurectomy, percutaneous radiofrequency foramina! rhizotomy, Bischof myelotomy,
selective dorsal rhizotomy, stereotactic thalamotomy, or dentatotomy.
(Greenberg 15. Functional Neurosurgery no. 19)
185. What are the ablative procedures with sacrifice of ambulation used for the treatment
of spasticity? Name one. intrathecal injection of phenol, selective anterior rhizotomy,
neurectomy, intramuscular neurolysis, cordectomy, cordotomy
(Greenberg 15. Functional Neurosurgery no. 20)
186. True or False. Fibers that are more sensitive to radiofrequency rhizotomy are
a small unmyelinated sensory fibers true
b large myelinated alpha motor fibers false
(Greenberg 15. Functional Neurosurgery no. 21)
187. True or False. Spasticity can be treated with intrathecal baclofen pumps.
Complications are mainly
a pump underinfusion false
b wound complications false
c catheter complications true (Catheter complications may have a frequency of up to
30% in baclofen pumps.)
d drug resistance false
(Greenberg 15. Functional Neurosurgery no. 22)
188. What is another name for torticollis? wry neck
(Greenberg 15. Functional Neurosurgery no. 23)
189. What muscle is usually affected in spasmodic torticollis? Sternocleidomastoid
(Greenberg 15. Functional Neurosurgery no. 24)
190. What are the surgical procedures used for the treatment of spasmodic torticollis?
a stimulate dorsal cord
b inject botulinum toxin
c cut rhizotomy
d coagulate Forel's Hl
(Greenberg 15. Functional Neurosurgery no. 25)
191. What artery is most commonly implicated in the torticollis of the eleventh nerve
origin? Vertebra
(Greenberg 15. Functional Neurosurgery no. 26)
192. True or False. Hemifacial spasm (HFS) and spreads to the upper half of the face.
false (starts with the starts from the lower half of the face orbicularis oculi)
(Greenberg 15. Functional Neurosurgery no. 27)
193. What distinguishes HFS from facialmyokymia (FM)?
a HFS is unilateral
b Blepharospasm is bilateral
(Greenberg 15. Functional Neurosurgery no. 28)
194. What is the only other involuntary palatal myoclonus movement disorder besides
HFS that persists during sleep? palatal myoclonus
(Greenberg 15. Functional Neurosurgery no. 30)
195. Complete the following statements about neurovascular compression syndromes:
a On what side is HFS more common? left
b What is the age and gender predilection? Women, after the teen ages
c What is the most commonly involved artery? AICA
d True or False. Carbamazepine and phenytoin are generally effective treatment. false
e What is the material used as a cushion in the microvascular decompression (MVD)7
? lvalon, polyinyl formyl alcohol foam
(Greenberg 15. Functional Neurosurgery no. 31)
196. True or False. The vessel most commonly associated with hemifacial spasm is
a posterior inferior cerebel lar artery (PICA) false
b superior cerebellar artery (SCA) false
c anterior inferior cerebellar artery (AICA) true
d posterior cerebral artery (PCA) false
e vertebral artery false
f basilar artery false
(Greenberg 15. Functional Neurosurgery no. 32)
197. Hemifacial spasm
a is caused by compression at the root entry zone
b of the facial nerve
c by the AICA
d This does not cause ephaptic conduction but
e produces kindling
f and synkinesis
(Greenberg 15. Functional Neurosurgery no. 33)
198. Synkinesis is a phenomenon where
a stimulation of facial nerve of the one branch
b results in delayed discharges
218.
a
b
c
d
ii.
burning pain
iii.
trophic changes
b What is the cause of major causalgia? high-velocity missile injury
c Allodynia is pain induced by non-noxious stimulus
d Signs of causalgia:
i.
tapered fingers
ii.
hands are and cold and moist
iii.
touching causes pain
iv.
also known as allodyni
e Current name for causalgia is complex regional pain syndrome (CRPS)
(Greenberg 16. Pain no. 29)
234. Complete the following statements about causalgia:
a Medical treatment for causalgia uses tricyclic antidepressants
b A common agent used for intravenous injection for causalgia is guanethedine
c Surgical sympathectomy may relieve thepain of causalgia in 50 %
(Greenberg 16. Pain no. 30)
235. Is stereotactic radiosurgery {SRS) useful for:
a venous angiomas? no
b cavernous angiomas? No
(Greenberg 18. Radiation Therapy no. 1)
236. Complete the following about stereotactic surgery
a For most cases what is the optimal treatment for vestibular schwannoma? surgery
b What alternative is available? SRS
c When would the alternative for the patient be considered?
i.
poor medical condition
ii.
older age group
(Greenberg 18. Radiation Therapy no. 2)
237. With stereotactic radiosurgery:
a Accuracy is never better than __ 0.6 mm
b If embolization is used what precaution is advised before SRS? wait 30 days between
procedures
c What dose is optimal for an arteriovenous malformation (AVM)? 1 0 to 15 Gy to
periphery of AVM
d What dose is optimal for tumors? 1 0 to 15 Gy with tumor in the 80% isodose line
e What dose is optimal for metastatic tumors? 15 Gy to center of tumor in the 80%
isodose line
(Greenberg 18. Radiation Therapy no. 3)
238. Complete the following regarding theresults, in percent, of SRS obliterationof:
a AVM
i.
AVM at 1 year 46 to 61 %
ii.
AVM at 2 years 86 %
iii.
under 2 cm 94 %
iv.
over 2.5 cm 50 %
b acoustic tumor
i.
decreased in size 44 %
ii.
stabilized in size 42 %
iii.
increased in size 14 %
c local metastatic control 88%
(Greenberg 18. Radiation Therapy no. 4)
239. What is advised if, after SRS, an AVM persists after 2 to 3 years? may re-treat with
SRS again
(Greenberg 18. Radiation Therapy no. 5)
240. Is there any difference in outcome toSRS by radio-resistant versus radio-sensitive
tumors? no
(Greenberg 18. Radiation Therapy no. 6)
241. Which has a better response, supra- o infratentorial metastases? supra
(Greenberg 18. Radiation Therapy no. 7)
242. Which premedication is given before SRS? steroids and phenobarbital
(Greenberg 18. Radiation Therapy no. 8)
243. During the latency period is there a higher incidence of hemorrhage from AVM? no,
approximately 3 to 4%/year
(Greenberg 18. Radiation Therapy no. 9)
244. For interstitial brachytherapy:
a How much radiation is given? 60 Gy
b To what area? a volume that extends 1 cm beyond the contrast enhancing tumor
c At what rate? 40 to 50 c Gy/h
d For how many days? 6
e What is the radiation amount that will cause tumor growth to stop? 30 c Gy/h
f With this protocol what percent of patients develop symptomatic radiation necrosis?
40%
(Greenberg 18. Radiation Therapy no. 10)
245. True or False. Indications for stereotacti surgery include:
a biopsy of multiple lesions . true
b brachytherapy implants . true (catheter placement for brachytherapy)
c treatment of chronic pain . true (electrode placement for pain, seizures)
d gamma knife radiosurgery. true (lesion generation for trigeminal pain)
e biopsy of a deep cerebral lesion . true
f hematoma evacuation . true (evacuation of intracerebral hemorrhage,cystic fluid)
g localization of lesion for open craniotomy. true
(Greenberg 19. Stereotactic Surgery no. 1)
246. True or False. Stereotactic biopsy contraindications include:
a coagulopathy . true
b multiple lesions . false (Multiple lesions are anindication for stereotactic biopsy.)
c brain stem lesions . false (A brain stem lesion is an indication for stereotactic
biopsy.)
d inabi lity to tolerate general anesthesia . false (can usually tolerate local anesthesia)
e thrombocytopenia . true (Platelets below 50,000 are an absolute contraindication to
biopsy.)
f inability to cooperate for biopsy. false (may do stereotactic biopsy under general
anesthesia)
(Greenberg 19. Stereotactic Surgery no. 2)
247. True or False. The yield rate for stereotactic biopsy is:
a higher for enhancing lesions than for nonenhancing . true
b lower for enhancing lesions than nonenhancing . false
c enhancing and nonenhancing lesions have equal yield rates. False
(Greenberg 19. Stereotactic Surgery no. 3)
248. True or False. The most common complication of stereotactic surgery is:
a hemorrhage. true (Most are too small to be clinically significant. The hemorrhage rate
is higher in AIDS and in central nervous system lymphoma.)
b infection . false
c inabi lity to localize lesion .false
d inabil ity to provide sufficient tissue qual ity/ quantity for biopsy .false
(Greenberg 19. Stereotactic Surgery no. 4)
249. Regarding stereotactic biopsy:
a True or False. The risk for major complication due to stereotactic biopsy is higher
in patients with multifocal high grade gliomas than in patients with AIDS. false
b Relative risk for patients that are
i.
immune compromised 0-12 %
ii.
nonimmune compromised 0-3 %
iii.
or have glioma 3 %
(Greenberg 19. Stereotactic Surgery no. 5)
250. True or False. The peripheral nervou system includes:
a spinal nerves . true
b all cranial nerves .false
c cranial nerves II I-XII . true
d cervical, brachial, lumbosacral plexus .true
(Greenberg 20. Peripheral Nerves no. 1)
251. True or False. Upper motor neuron paralysis includes:
a clorius . true
b hyperactive reflexes . true
c muscle spasms .true
d atrophy . false
e fasciculations . false (Choices d and e are characteristic of lower motor neuron
paralysis.)
(Greenberg 20. Peripheral Nerves no. 2)
252. List the 11 muscles of the shoulder and arm and nerves to test:
a muscle trapezius, nerve CN Xl spinal accessory , roots, C3,4
b muscle serratus anterior, nerve long thoracic, roots C 5,6,7
c muscle suprasupinatus , nerve suprascapular, roots C 4,5,6
d muscle infraspinatus , nervesuprascapular, roots C 5,6
e muscle rhomboids, nerve dorsal scapular, roots C 4,5
f muscle pectoralis minor, nerve anterior thoracic (med) AKA pectoral nerve, roots C 7,8
g muscle pectoralis major , nerve (lat. Anterior thoracic anterior thoracic med) AKA
pectoral nerve, roots C4,5,6,7,8,
h muscle latissimus dorsi, nerve thoracodorsal, roots C 5,6,7,8
i muscle deltoid, nerve axillary, roots C 5,6,
j muscle brachialis , nerve musculocutaneus, roots C 5,6
k muscle biceps, nerve musculocutaneus, roots C 5,6
(Greenberg 20. Peripheral Nerves no. 3)
253. List 11 muscles of the shoulder and arm, their nerve, and their action.
a muscle trapezius , nerve CNXl , action shrug shoulder
b muscle serratus anterior , nerve long thoracic , action forward shoulder thrust
c muscle supraspinatus , nerve supracapsular, action abduct arm 90 degrees
d muscle infraspinatus , nerve supracapsular , action backhand tennis shot
e muscle rhomboids , nerve dorsal scapular , action abduct scapulae
f muscle pectoralis minor , nerve pectoral nerve medial , action adduction arm
g muscle pectoralis major , nerve pectoral nerve lateral and medial , action adduction
arm and push arm forward
h muscle latissimus dorsi , nerve thoracodorsal , action adduct arm, ladder climb, cough
j muscle deltoid , nerve axillary, action abduct arm > 90 degrees
k muscle brachialis , nerve musculocutaneous , action flex forearm
l muscle biceps , nerve musculocutaneous , action flex and supinate forearm
(Greenberg 20. Peripheral Nerves no. 4)
254. True or False. The suprascapular nerve innervates:
a teres major . false-subscapular nerve (C5 -7)
b teres minor false-axillary nerve (C4 - 5)
c infraspinatus true
d supraspinatus true
(Greenberg 20. Peripheral Nerves no. 5)
255. The suprascapular nerve contains roots from C 4,5,6
(Greenberg 20. Peripheral Nerves no. 6)
256. Describe the latissimus dorsi muscle:
a function
ladder climbing
cough
adductor-together with pectoralis
b nerve thoracodorsal nerve
c cord posterior cord
d roots C 6,7,8
(Greenberg 20. Peripheral Nerves no. 7)
257. True or False. The deltoid muscle:
a abducts arm 0 to 90 degrees false (The arm is abducted 0 to 90 degrees by the
supraspinatous muscle.)
b abduct arm > 90 degrees .true
c is innervated by the axillary nerve. true
d rotates the arm out . false (Arm is rotated out by the infraspinatus muscle.)
(Greenberg 20. Peripheral Nerves no. 8)
258. True or False. The abductor pollicis longus
a is innervated by the median nerve false
b is innervated by the radial nerve true
c is innervated by the ulnar nerve false
d is innervated by the posterior interosseous nerve true (The posterior interosseus nerve
is a continuation of the radial nerve in the forearm.)
(Greenberg 20. Peripheral Nerves no. 9)
259. True or False. The median nerve is responsible for the following movements of the
thumb:
a adduction . false (served by ulnar nerve)
b abduction . true
c extension .false (served by radial nerve)
d flexion .true
e opposition . true
(Greenberg 20. Peripheral Nerves no. 10)
260. Complete the following about the movements of the thumb:
a Actions of nerves to the thumb:
i median nerve, Hint: FAO
Flexion action muscle flexor pollicis brevis and longus root C 8, T1 , median
A-action abduction, muscle abductor pollicis brevis , root C 8, T1 , median
O-action opposition, muscle opponens pollicis, root C8, T1
ii ulnar nerve
action adduction, muscle adductor pollicis , root C 8, T1
iii. radial nerve
action extension , muscle extensor pollicis brevis and longus , root C7, C8
b Plane of movement for the thumb:
i.
extension is plane of palm
ii.
flexion is plane of palm
iii.
adduction is perpendicular to palm
iv.
abduction is perpendicular from palm
v.
opposition is across the palm
(Greenberg 20. Peripheral Nerves no. 11)
261. Complete the fol lowing about peripheral nerves: Hint: fosis pdstp follow our sign.
it says "please don't spoil the plants"
femoral
obturator
superior gluteal
inferior gluteal
sciatic (trunk)
peroneal (trunk)
deep peroneal
superficial peroneal
tibial
pudendal
(Greenberg 20. Peripheral Nerves no. 12)
262. Name the nerves of the lower extremities and the roots that form them:
femoral, 1,2,3
obturator, 2,3
superior gluteal, 4, 5, 51
inferior gluteal, 5, 51, 52
sciatic, 5, 51, 52
peroneal, 4, 5, 51
deep peroneal, 4, 5
superficial peroneal, 5, 51
tibial, 4, 5, 51, 52, 53
pudendal, 52, 53, 54
(Greenberg 20. Peripheral Nerves no. 13)
263. Name the nerves of the lower extremities and the muscles and function of the
muscles they serve:
a nerve femoral, muscle iliopsoas, quadriceps femoris, sartorius , function flex hip
a nerve , muscle , function
a nerve obturator , muscle adductor , function adduct thigh
a nerve superior gluteal , muscle gluteus medius , function abduct thigh
a nerve inferior gluteal , muscle gluteus maximus , function flex leg
a nerve sciatic trunk , muscle biceps femoris, semi tendenosis, semi membranosis,
function extend thigh
a nerve deep peroneal, muscle tibialis anterior, extension hallucis longus (EHL),
function great toe extension, foot dors, flexion,
a nerve superficial peroneal , muscle peroneus longus , function plantar flexion foot and
toes
a nerve tibial , muscle posterior tibial, gastrocnemius, soleus, flexor hallacis longus
(FHL) , function plantar flex foot and toes,
a nerve pudendal , muscle perineal, sphincters, function voluntary contraction of pelvic
floor
(Greenberg 20. Peripheral Nerves no. 14)
Fig. 20.1
(Greenberg 20. Peripheral Nerves no. 20)
270.
271. Add the nerves to the basic outline of the brachial plexus nerves: 16. Hint: Donald
says somewhat loudly Mickey Mouse you are right to so sincerely love Minnie Mouse
madly.
Fig. 20.3
(Greenberg 20. Peripheral Nerves no. 22)
272.
Fig. 20.4
(Greenberg 20. Peripheral Nerves no. 23)
273.
Fig. 20.5
Draw the left brachial plexus and add details requested in questions 21 through 23
Fig. 20.6
(Greenberg 20. Peripheral Nerves no. 25)
275. Complete the following about the
brachial plexus:
a Name the roots (6}. C4, C5, C6, C7, C8, Tl
b Name the segments (5}. Hint: Run to do Cindy's needs. roots. trunks, divisions,
chords, nerves
c Name the nerves (1 6}. Hint: Donald says somewhat loudly Mickey Mouse you are
right to so sincerely love Minnie Mouse madly.
dorsal scapular
suprascapular
subclavius
lateral pectoral
musculocutaneous
median
ulnar
axillary
radial
thoracodorsal
subscapular upper
subscapular lower
long thoracic
medial pectoral
medial brachial cutaneous
medial antebrachial
cutaneous
d Name the trunks (3} superior, middle, inferior,
e Name the cords (3} lateral, medial, posterior
(Greenberg 20. Peripheral Nerves no. 26)
276. Trace, using the brachial plexus diagram, the theoretically possible root contribution
to each nerve and then compare with the actual root contribution in each nerve.
a nerve dorsal scapular, theoretical C4,5 , actual, C4,5,
b nerve suprascapular , theoretical C4,5,6 , actual C 4,5,6
c nerve subclavius, theoretical C 6, actual C 6
d nerve lateral pectoral, theoretical C 4,5,6,7, actual C 4,5,6,7
e nerve musculocutaneous, theoretical C 5,6,7, actual C 5,6,7,
f nerve median, theoretical C 5,6,7 T 1, actual C 5,6,7 T 1
g nerve ulnar, theoretical C 8, T1, actual C 7,8, T1
h nerve axillary, theoretical C4,5,6,7,8, T1 , actual C4,5,6,7,8, T1
(Greenberg 20. Peripheral Nerves no. 27)
277. List the brachial plexus nerves (except for median ulnar and radial), the muscles
they serve, the roots that are inthat nerve, and the action of the muscles:
a nerve dorsal scapular, muscle levator scapulae, root C3,4;5 , action, elevate scapulae
b nerve dorsal scapular, muscle rhomboids, root C 4,5 action, adduct and elevate scapula,
c nerve suprascapular, muscle supraspinatus, root C 4,5,6 , action, adduct arm 0- 90
degrees
d nerve supraspinatus , muscle infraspinatus,, root C 5,6, action rotate arm out
e nerve musculocutaneous , muscle biceps brachii, root C 5,6, action lex and supinate
forearm,
f nerve musculocutaneous , muscle coracobrachialis, root C 5,6,7, action flex and adduct
forearm,
g nerve musculocutaneous , muscle brachialis, root C 5,6, action flex forearm
h nerve axillary , muscle deltoid, root C 5,6 , action abduct arm > 90 degrees
i nerve subscapularis , muscle teres major, root C5,6,7, action adducts arm
j nerve thoracodorsal , muscle latissimus dorsi, root C5,6,7,8 , action adduct arm ladder,
cough,
k nerve axillary , muscle teres minor , root C4,5 , action rotation lateral
l nerve long thoracic , muscle serratus anterior , root C5,6,7 , action forward shoulder
thrust
(Greenberg 20. Peripheral Nerves no. 28)
278. Considering the brachial plexus and radial nerve, list the branches of the radial
nerve cascade in proper sequence and the function of the muscles. Hint: rest in peace,
retbes in peeeeeae
radial
extensor
triceps
brachioradialis
extensor carpi radialis
supinator
i
n posterior interosseres nerve
p
extensor carpi ulnaris
extensor digitorum communis
b
i. f flexor carpi radialis
ii. function: radial flexion of hand
c
i. palmaris longus
ii. function: hand flexion
d
i. flexor digitorum superficialis
ii. function: flex middle phalanx, fingers 2 , fingers to 5
e
i. flexor digitorum profundus
ii. function: flex distal phalanx, fingers 2 fingers to 3
f
i. flexor pollicis longus
ii. function: flex distal phalanx of thumb
g
i. pronator quadratus
ii. function: pronates forearm
h
i. flexor pollicis brevis
ii. function: flexes procimal phalanx of thumb
i.
i. abductor pollicis brevis
ii.function: abducts thumb metacarpal
j
i. opponens pollicis
ii. function: opposes thumb metacarpal
k
i. 1 and 2 lumbricales
ii. function: extend 2 distal phalanges of fingers 4 and 5
(Greenberg 20. Peripheral Nerves no. 34)
284. Which muscles in the hand are innervated by the median nerve? Hint: loaf
lumbricals 1 and 2
opponens pollicis
abductor pollicis brevis
flexor pollicis brevis
(Greenberg 20. Peripheral Nerves no. 35)
285. Which muscles are served by the anterior interosseous nerve?
flexor digitorum profundus
flexor pollicis longus
pronator quadratus
(Greenberg 20. Peripheral Nerves no. 36)
286. Regarding the brachial plexus and ulnar nerve, list the muscles served by the ulnar
nerve cascade in proper order and the function of the muscles. Hint: "Ffafner I Love
Him"
PEEEEEAE
Median
Radial
PFPF3PFAOL radial
extensor
triceps
brachioradiali
s
exteilsor carpi
radialis
Ulnar
Median
flexor carpi
ulnaris
flexor
digitorum
profundus
adductor
pollicis
flexor
pollicis
brevis
interossei
pronator
teres
flexor carpi
radialis
supinator
lumbricales
hypothenar
almaris
longus
flexor
digitorum
superficialis
flexor
digitorum
profundus
flexor
pollicis
longus
(AIN)
flexor
pollicis
brevis
abductor
pollicis
brevis
n
p
(PIN)
opponens
pollicis
opponens
pollicis
extensor carpi
ulnaris
extensor
digitorum
extensor digiti
minimi
extensor
pollicis brevis
extensor
pollicis
longus
abductor
pollicis
longus
extensor
indicis
(Greenberg 20. Peripheral Nerves no. 38)
288. Which muscles in the arm are innervated by the ulnar nerve? none
(Greenberg 20. Peripheral Nerves no. 39)
289. Regarding the following additional (2) nerves of the brachial plexus, number the
roots and name the muscles and their actions:
nerve musculocutaneous, roots C 5,6,7, muscles (1) biceps, (2) coracobrachialis, (3)
brachialis, action (1) flex forearm and supinates,(2) flex forearm and adducts, (3) flex
forearm
nerve axillary , roots C4,5,6 , muscles (1) deltoid, (2) teres minor action (1) abduct arm
30 to 90 degrees, (2) lateral arm rotation
(Greenberg 20. Peripheral Nerves no. 40)
290. Peripheral neuropathy-list the etiology: Hint: dang the rapist
diabetes
alcohol
nutritional, B12
Guillain-Barre
traumatic
hereditary
entrapment
renal, radiation
amyloid
porphyria, paraneoplastic
infectious, Hanson's
sarcoidosis
toxins, heavy metals
(Greenberg 20. Peripheral Nerves no. 41)
291. Regarding peripheral neuropathy:
The most common peripheral neuropathy that is an inherited disorder is Charcot-MarieTooth syndrome
The percent of patients with diabetes mel litus who develop diabetic neuropathy is 50%
(Greenberg 20. Peripheral Nerves no. 42)
292. Which syndrome is associated with pure sensory neuropathy? paraneoplastic
syndrome (also seen with pyridoxine therapy)
(Greenberg 20. Peripheral Nerves no. 43)
293. True or False. Alcohol neuropathy includes:
a motor neuropathy . false
b sensory neuropathy . true
c absent Achilles reflex . true
d intense pain. False
(Greenberg 20. Peripheral Nerves no. 44)
294. True or False. The most important study in the diagnosis of lumbosacral plexus
neuropathy is:
a magnetic resonance imaging (MRI) . false
b computed tomography (CT) . false
c electromyography (EMG) . true (EMG in lumbosacral neuropathy-rule out diabetic
neuropathy!)
d erythrocyte sedimentation rate (ESR). False
(Greenberg 20. Peripheral Nerves no. 45)
295. EMG in lumbosacral neuropathy shows what in regards to:
a fibrillation potententials increased
b motor unit potentials in number decreased
c motor unit potentials in amplitude increased
d motor unit potentials in duration increased
e motor unit potentials that are polyphasic
f have changes involving at least 2 segments
g spare diagnostic the paraspinal muscles is highly
(Greenberg 20. Peripheral Nerves no. 46)
296. True or False. Femoral neuropathy includes:
a weakness of quadriceps and il iopsoas . true
b patellar reflex-reduced .true
c femoral stretch-positive .true
sensation
second degree axon injured; endo-, peri-, connective tissue is epineurium intact,
(endoneurium provided tube for regeneration) _
third degree axon and endoneurium disrupted (grossly normal appearance, recovery
related to extent of intrafascicular fibrosis)
(Greenberg 20. Peripheral Nerves no. 52)
302. Complete the following about the peripheral neuropathies:
a fourth degree axon endoperi interruption of all elements but epineurium is intact,
nerve is indurated and enlarged
b fifth degree axon endoperi and epineurium is completely transected
c sixth degree mixed first through fourth through degree injuries completely
(Greenberg 20. Peripheral Nerves no. 53)
303. Complete the following about the peripheral neuropathies:
a Nerve regeneration occurs at the rate of 1 mm/day.
b Nerve regeneration occurs at the rate of 1 inch/fmonth.
c Describe injury classification of peripheranerves and regeneration prognosis.
axon compressed two classifications: Seddon and Sunderland first degree = Seddon
neuropraxia; conduction block from compression or ischemia; anatomy preserved
axon injured second degree = Seddon axonotmesis; injury to axon with Wallerian
degeneration; endoneurium/perineurium/ epineurium intact; endoneurium provides
"tube" to optimize successful reinnervation of target muscle
axon and endoneurium disrupted third degree = axon and endoneurium disrupted;
recovery inversely related to interfascicular fibrosis; gross normal appearance
axon, endoneurium and perineurium disrupted fourth degree = interruption axon.
endoneurium, perineurium; gross reveals indurated enlarged nerve
axon endo-, peri-, and epineurium disrupted fifth degree = Seddon neurotmesis;
complete transection of axon, endo-, peri-, epineurium
(Greenberg 20. Peripheral Nerves no. 54)
304. What are etiologies of brachial plexus injuries? Hint: cpt
compression
penetration
traction
(Greenberg 20. Peripheral Nerves no. 55)
305. Traction (stretch) injuries of the brachial plexus selectively:
a spare the
i.
medial cord
ii.
median nerve
b injure the
i.
posterior cord
ii.
lateral cord
(Greenberg 20. Peripheral Nerves no. 56)
e bilateral 4%
(Greenberg 20. Peripheral Nerves no. 63)
313. True or False. The following are indications for early surgical exploration of the
brachial plexus:
any injury needs repair . false (most injuries maximal deficit at onset then improve)
progressive deficit . true (progressive deficit likely vascular injury, explore immediately)
clean sharp injury . true (clean, sharp, fresh lacerating injuries -+ explore acutely and
repair end-tcrend tension-free within 72 hours)
gunshot wound (GSW) to brachial plexus. false (surgery is of little benefit)
(Greenberg 20. Peripheral Nerves no. 64)
314. List medical etiologies of entrapment neuropathies:
arthritis rheumatoid
acromegaly
amyloidosis
polymyalgia rheumatica
carcinomatosis
diabetes
gout
hypothyroidism
(Greenberg 20. Peripheral Nerves no. 65)
315. Name two most common syndromes of median nerve entrapment:
carpal tunnel syndrome
pronator teres syndrome
(Greenberg 19. Stereotactic Surgery no. 66)
316. Describe carpal tunnel syndrome (CTS) anatomy:
a The median nerve passes under the transverse carpal ligament
b The motor branch either goes:
under or
pierces the ligament
c and serves the loaf muscles,
d which are:
limbricales 1 and 2
opponens pollicis
abductor pollicis
flexor pollicis brevis
(Greenberg 20. Peripheral Nerves no. 67)
317. Concerning carpal tunnel syndrome:
a The transverse carpal ligament extends how far beyond the distal wrist crease? 3 cm
b What is the name of the sensory nerve? palmar cutaneous branch
c It arises 5,5 cm em proximal to the wrist.
splint
steroids
surgery
b Incision should be slightly to the ulnar side of the interthenar crease
c to avoid
palmar cutaneous branch
anomalous recurrent thenar
motor branch
(Greenberg 20. Peripheral Nerves no. 73)
323. Describe main trunk median nerve compression:
a above elbow due to Struther ligament supracondylar to medial epicondyle, mostly
asymptomatic
b at elbow
i.
b a ___ _ bicipital aponeurosis
ii.
p t. ___ _ pronator teres
iii.
s b ___ _ sublimis bridge
c Honeymoon paralysis is due to direct compression
d Benediction hand is due to weakness of flexor digitorum profundus I and II.
(Greenberg 20. Peripheral Nerves no. 74)
324. Characterize pronator teres syndrome (PTS):
a compresses the nerve median
b where it dives between the two heads of the pronator teres
c Symptoms are:
i.
pain in the palm
ii.
weakness in the grip
iii.
paresthesias in the thumb and index fingers
d i. Differs from CTS in that there is no nocturnal pain in pronator teres syndrome
ii. but there is pain in the palm in PTS
iii. because the median palmar cutaneous branch is compressed in PTS and spared
in carpal tunnel syndrome
(Greenberg 20. Peripheral Nerves no. 75)
325. Describe pronator teres syndrome:
a.
i.
caused by repeated pronation
ii.
with a tight fist
b.
i.
due to nerve trapped where it dives between
ii.
two heads of the pronator teres
c .symptoms of:
ache
pain in palm
weak grip
d Distinguished from carpal tunnel syndrome by:
no nocturnal exacerbation
pain in palm
(Greenberg 20. Peripheral Nerves no. 76)
326. What are the key features of anterior interosseous neuropathy?
a.
flexion
distal phalanges
thumb
index finger
b.due to
weakness of the flexor digitorum profundus and the
flexor pollicus longus
c.no loss of sensation (anterior interosseous is pure motor)
d. patient can't make "OK" sign
e treatment:
no identifiable causeexpectant; management 8 to 12 weeks
if no improvement or if progression proceed with
surgical exploration
(Greenberg 20. Peripheral Nerves no. 77)
327.Regarding the anterior interosseous nerve:
a If injured a person can't do what with the thumb and index finger ? make an "0"
b because there is weakness of the:
i. flexor digitorum profundus and
ii. flexor pollicis longus
c Is part of what nerve? median
d Syndrome may be caused by constricting ligament.
e Is there any sensory loss? no sensory loss
(Greenberg 20. Peripheral Nerves no. 78)
328.Regarding the ulnar nerve:
a Name the roots: ulnar components C7, C8, T1
b Motor findings of entrapment? Hint: abcWF
interossei wasting; atrophy,
particularly thumb web space
benediction hand
claw deformity
Wartenberg sign: abducted
little finger
Froment thumb sign
c
i. pain and tingling in little finger
ii. and ulnar half ring finger
(Greenberg 20. Peripheral Nerves no. 79)
329.Ulnar nerve entrapment results in:
333.What are surgical treatment options for ulnar compression at the elbow?
a de without simple nerve decompression without transposition
b de nerve decompression with transposition
c medial epicondylectomy
d Results in %:
i. excellent 60 %
ii. fair 25 %
iii. poor 15 %
e True or False. What responds better ?
i. pain and sensory loss . true
ii. weakness and atrophy . false
(Greenberg 20. Peripheral Nerves no. 84)
334. Entrapment in the forearm-<:ubital tunnel syndrome:
a Involves which nerve? ulnar
b Due to which muscle? flexor carpi ulnaris (Just distal to the elbow, the ulnar nerve
passes from the groove between the)
c The mechanism is compression between the medial epicondyle and the olecranon
process to enter the two heads of the flexor carpi ulnaris under the fascial band
connecting the two heads (the cubital tunnel)
d results in: atrophy of the interrossei, Wartenberg sign, Froment prehensile thumb
sign, claw deformity of the hand (main en griffe)
(Greenberg 20. Peripheral Nerves no. 85)
335. Characteristics of the cubital tunnel syndrome are: Hint: ccubittal
claw deformity
(flexor) carpi ulnaris
ulnar nerve
band is tight
interossei atrophied
thumb sign Froment prehensile
two heads of flexor carpi ulnaris
atrophy of interossei
elbow epicondyle
(Greenberg 20. Peripheral Nerves no. 86)
336. Describe the borders of the Guyon canal:
a roof:
palmar fascia ,
palmar brevis muscle
b floor
flexor retinaculum of the palm
pisohamate ligament
c Below the floor is the transverse carpal ligament
d It contains only the ulnar (At the middle of the canal the nerve divides into deep and
superficial branch. Superficial branch is mostly sensory [except for the branch to palmar
brevis) and supplies hypothenar eminence and ulnar half of ring finger. The deep
[muscular) branch innervates hypothenar muscles, lumbricals 3, 4, and interossei. nerve
and artery.
(Greenberg 20. Peripheral Nerves no. 87)
337. Describe types of ulnar nerve lesions in Guyon canal type-location of compressionweakness-sensory deficit.
a type I
location of compression just proximal to or within Guyon canal,
weakness all intrinsic muscles innervated by ulnar nerve ,
sensory deficit palmar ulnar distribution (palmar ulnar distribution: the
hypothenareminence and ulnar half of ring finger both on the palmar surface only)
b type II
location of compression along deep branch
weakness muscles innervated by deep branch (depending on location may spare
hypothenar muscles)
sensory deficit none
c type Ill
location of compression distal end of Guyon canal
weakness none
sensory deficit palmar ulnar distribution (the hypothenar eminence and ulnar half of ring
finger both on the palmar surface only)
(Greenberg 20. Peripheral Nerves no. 88)
338. Regarding radial nerve injuries:
a. Sensation loss in the web space of the thumb indicates injury in the hand
b. Pain at the lateral epicondyle indicates compression of the supinator tunnel at the
elbow
c.
i Finger drop indicates injury to the PIN
ii. resulting from entrapment at the arcade of Frohse
d.
i.
Wrist drop indicates injury to mid-upper arm
ii.
where the nerve is in the spiral groove along deep branch
e. Triceps plus all distal muscle weakness axilla indicates injury at the axilla
f. above plus weakness of the deltoid and posterior cord latissimus dorsi indicates
injury to the posterior cord
g. above plus winging of the scapula on the roots forward shoulder thrust indicates
injury to the roots.
(Greenberg 20. Peripheral Nerves no. 89)
339. Differentiate radial nerve injury from brachial plexus posterior cord injury.
a Check the function of the and deltoid
b latissimus dorsi radial nerve arises from posterior divisions of the three trunksof the
brachial plexus to form the posterior cord. Sparing of deltoid (axillary) and latissimus
dorsi (thoracodorsal) localizes injury to radial nerve and not the more proximal portion
of the posterior cord. muscles.
dorsiflexing the right foot. This new complaint probably represents which of the
following disorders?
a. Borrelia radiculopathy
b. Diabetic mononeuritis multiplex
c. Isoniazid neuropathy
d. Rifampin toxicity
e. Tuberculous radiculopathy
Jawab:A
363. Eventually, the physician receives results of a diagnostic test and switches the patient
to a cephalosporin. The mans facial strength improves, but he notices twitching of the
left corner of his mouth whenever he blinks his eye. This involuntary movement disorder
is probably an indication of which of the following?
a. Sarcoidosis
b. Recurrent meningitis
c. Aberrant nerve regeneration
d. Mononeuritis multiplex
e. Cranial nerve amyotrophic lateral sclerosis (ALS)
Jawab:C
364. A 25-year-old woman is being examined by her physician. The knee jerk is being
tested. The patellar tendon reflex involves sensory fibers of the femoral nerve that
originate in spinal segments
a. S3S4
b. S2S3
c. S1S2
d. L4L5
e. L2L3
Jawab:E
365. A 51-year-old factory worker has noticed progressive weakness over the past year.
Examination and testing reveal a painless largely motor peripheral neuropathy. Of the
following agents, the one most likely to be etiologic in this case is
a. Lead
b. Manganese
c. Thallium
d. Cyanide
e. Mercury
Jawab:A
366.
367. A very thin elderly woman complains of left-sided neck pain. Her family attempted to
give her a deep intramuscular injection of steroids. She complains acutely of pain
radiating down her arm and develops a wrist-drop. The probable site of injection is the
a. Posterior cord of the brachial plexus
b. Medial cord of the brachial plexus
c. Lateral cord of the brachial plexus
d. T1 spinal root
e. C5 spinal root
Jawab:A
368.
Injuries limited to the upper brachial plexus are most likely with
a. Node dissections in the axilla
b. Pancoast tumor
c. Birth trauma
d. Dislocation of the head of the humerus
e. Aneurysm of the subclavian artery
Jawab:C
369.
The most prominent areas of degeneration with Friedreichs disease are in the
a. Cerebellar cortex
b. Inferior olivary nuclei
c. Anterior horns of the spinal cord
d. Spinocerebellar tracts
e. Spinothalamic tracts
Jawab:D
Items 370373
A 20-year-old ataxic woman with a family history of Friedreichs disease develops
polyuria and excessive thirst over the course of a few weeks. She notices that she
becomes fatigued easily and has intermittently blurred vision.
370. The most likely explanation for her symptoms is
a. Inappropriate antidiuretic hormone
b. Diabetes mellitus
c. Panhypopituitarism
d. Progressive adrenal insufficiency
e. Hypothyroidism
Jawab:B
371. The peripheral neuropathy that would be expected to be seen with this patient
develops in part because of degeneration in
a. Dorsal root ganglia
b. Spinocerebellar tracts
c. Anterior horn cells
d. Clarkes column
e. Posterior columns
Jawab:A
372.
e. The X chromosome
Jawab:B
373. If this patient has children, at what stage of life would they be expected to become
symptomatic if they inherited Friedreichs ataxia?
a. Neonatal period
b. Juvenile period
c. Early adulthood
d. Middle age
e. Senescence
Jawab:B
Items 374373
A 17-year-old male presents with 10 days of progressive tingling paresthesias of the
hands and feet followed by evolution of weakness of the legs two evenings before
admission. He complains of back pain. He has a history of a diarrheal illness 2 weeks
prior. On examination, he has moderate leg and mild arm weakness, but respiratory
function is normal. There is mild sensory loss in the feet. He is areflexic. Mental status is
normal.
374. Spinal fluid analysis in this case is most likely to show
a. No abnormalities
b. Elevated protein level
c. Elevated white blood cell (WBC) count
d. Elevated pressure
e. Oligoclonal bands
Jawab:B
375.
The most frequent preceding infection before the onset of this syndrome is
a. HIV
b. Cytomegalovirus (CMV)
c. Chlamydia psittaci
d. Mycoplasma pneumoniae
e. Campylobacter jejuni
Jawab:E
376. Over the course of the following week, he has further evolution of weakness
involving muscles of the arms, face, and respiration. He is intubated and placed in the
intensive care unit. Nerve conduction and electromyogram (EMG) studies show
widespread demyelination. Therapy with which of the following may help to speed
recovery?
a. Corticosteroids
b. Cyclophosphamide
c. Plasma exchange
d. Albumin infusions
e. 3,4-diaminopyridine
Jawab:C
DIRECTIONS: Each group of questions below consists of lettered options followed by a
set of numbered items. For each numbered item, select the one lettered option with which
it is most closely associated. Each lettered option may be used once, more than once, or
not at all.
Items 377380
Match each clinical scenario with the most likely diagnosis.
a. Charcot-Marie-Tooth disease
b. Fabrys disease
c. Riley-Day disease (familial dysautonomia)
d. Parsonage-Turner syndrome (brachial plexopathy)
e. Meralgia paresthetica
f. Chronic inflammatory demyelinating polyneuropathy (CIDP)
g. Acute intermittent porphyria
h. Reflex sympathetic dystrophy
i. Leprosy
j. Critical illness neuropathy
377. A 26-year-old woman develops the acute onset of left shoulder pain. Over the
following week, she develops weakness in the proximal left arm and mild sensory loss.
On examination, she has scapular winging and marked weakness of the left deltoid,
biceps, and triceps muscles. The right side is normal, as are her legs. Mild sensory loss in
the upper arm is found. She has lost her biceps and triceps reflexes. Her brother recently
had a similar problem. (SELECT 1 DIAGNOSIS)
Jawab:D
378. A 4-year-old Jewish child has a history of poor sucking at birth, as well as multiple
respiratory infections during childhood. He is of short stature and has not been able to eat
due to progressive vomiting. On examination, strength is normal, but he is hyporeflexic.
There is sensory disassociation, with loss of pain and temperature sensation and
preservation of tactile and vibratory sense. The corneas are ulcerated, pupils do not react,
and he has orthostatic hypotension. (SELECT 1 DIAGNOSIS)
Jawab:C
379. A 56-year-old woman has slowly worsening numbness and paresthesias of the hands
and feet, as well as proximal muscle weakness. Bulbar muscles are normal. An EMG
shows multifocal conduction block, slowing of nerve conduction, and minimal loss of
amplitude of muscle action potentials. Cerebrospinal fluid (CSF) exam shows an
elevation in protein to 260, but no increase in the number of cells. (SELECT 1
DIAGNOSIS)
Jawab:F
380. A 40-year-old police officer is given pain medications after a femoral fracture. One
week later, he presents with confusion, psychosis, abdominal pain, and vomiting. On
exam, he is tachycardic, hypertensive, and febrile. He appears delirious. His arms are
weak, sensation is relatively preserved, and he is areflexic. His wife relates that he had
similar episodes before, when he was in the military. (SELECT 1 DIAGNOSIS)
Jawab:G
Items 381383
381. For each clinical scenario, select the most likely condition.
a. Diabetes mellitus
b. Sarcoidosis
c. Thiamine deficiency
d.
e.
f.
g.
h.
i.
j.
Pyridoxine deficiency
Friedreichs disease
Nitrous oxide poisoning
Gout
Amyloid
Abetalipoproteinemia
Carcinoma