Intravenous Vitamin C
Intravenous Vitamin C
Vitamin C has a broad spectrum antioxidant function with the ability to protect cell structures and DNA
from free radical damage. Vitamin C is remarkably safe even in enormously high doses. Compared to
commonly used prescription drugs, side effects are virtually nonexistent. No matter how high the
concentration, vitamin C does not harm healthy cells. Yet, through an array of enzymatic and metabolic
reactions, vitamin C has an impressive ability to protect and treat and wide range of diseases, including
cancer. When something is this effective at treating disease, the FDA will stop at nothing to prevent public
access.
The benefits of long-term vitamin C consumption in excess of the U.S. government recommended daily
allowance (RDA) are widely acknowledged and include reduced risks of cancer, cardiovascular disease
and cataracts. Higher-than-RDA vitamin C intakes have been associated with increases in good HDL
cholesterol, decreases in LDL cholesterol oxidation, decreased blood pressure and decreased
cardiovascular mortality.
The first physician to aggressively use vitamin C to treat disease was Frederick R. Klenner, M.D.,
beginning in the early 1940s. Dr. Klenner successfully treated chicken pox, measles, mumps, tetanus and
polio with huge doses of vitamin C. He used massive doses of vitamin C for more than 40 years of family
practice. Many practioners who practice with IV vitamin C consider the treatment more effective than any
vaccine ever invented.
Vitamin C particularly has a leading antioxidant role in the intercellular space surrounding each cell. It also
has the ability to regenerate and optimize other key antioxidants such as vitamin E.
It is a water soluble vitamin scientifically known as ascorbic acid (reduced form). Its absorption is
relatively efficient at 70-90% for low doses. Any excess vitamin C that is not absorbed in the digestive
tract is excreted. This prevents overdose by oral ingestion. Humans are one of the few species of animal
that are not able to produce vitamin C. We rely on dietary intake to maintain stores. Many people with low
dietary intakes of fruits and vegetables have sub-optimal levels of vitamin C. In fact, cancer patients are
often shown to have very low levels of vitamin C.
Evidence documents Vitamin C as one of the best antiviral agents now available. Vitamin C can
neutralize and eliminate a wide range of toxins. Vitamin C will enhance host resistance, greatly
augmenting the immune systems ability to neutralize bacterial and fungal infections.
A study in the American Heart Journal found that the risk of heart failure increased with decreasing
plasma vitamin C; Every 20 .mol/L increase in plasma vitamin C concentration was associated with a 9%
relative reduction in risk of heart failure.
Vitamin C in Cancer Treatment
In the 1970s, doctors Ewan Cameron, Nikolaas Campbell, and Linus Pauling were the first to report the
use of high dose vitamin C to treat terminally ill cancer patients. They found that IV and oral treatments
increased survival times compared to those patients who did not receive treatments. Since the initial
studies by Cameron and Pauling, the exact anti-cancer mechanism of vitamin C has been studied and
clarified. Considering the various functions of vitamin C in the human body, two distinct modes of action
have been identified when it comes to cancer. For prevention, vitamin C has antioxidant effects that
protect key cellular structure and functions. It also prevents the formation of dangerous cancer-causing
compounds. The dose to achieve an antioxidant effect is low (under 2 grams) and is achievable by dietary
intake or oral supplementation.
The second mechanism of action is actually a pro-oxidant effect. Doses above 15 grams are proven to
have a pro-oxidant effect by generating hydrogen peroxide, which in turn selectively destroys cancer
cells. High doses of vitamin C are preferentially delivered to the areas surrounding the tumour because
the vitamin molecule looks similar to a sugar molecule and cancer cells have an increased demand for
sugar to fuel their unregulated growth. When in the area surrounding the cells, the vitamin C molecule
reacts with a metal ion such as iron or copper and forms a hydrogen peroxide molecule that damages the
cancer cell.
Over and above the pro- and antioxidant effects, vitamin C has been shown to regulate cell division via
the p53 protein (essential in cancer treatment and prevention), improve immune response, and reduce
the severity of cachexia (weight loss due to cancer). A recent study also found that high dose vitamin C
reduced C-reactive protein levels and pro-inflammation cytokines in cancer patients, which in turn had
positive effects on tumour markers.
Linus Pauling, PhD, and Ewan Cameron, MD, published a case report about 100 terminal cancer patients
who had been treated with high-dose IV and oral vitamin C. The patients who received this therapy
survived an average of 300 days longer than a control group of patients with similar disease status, and
22 percent of them lived longer than one year, compared to just 0.4 percent in the control group.
Based on these results, Dr. Pauling convinced the National Cancer Institute (NCI) to evaluate this therapy
in a clinical trial of patients with advanced cancer. But when the results were published, vitamin C showed
no therapeutic value. Why? Because rather than using IV and oral vitamin C as Drs. Pauling and
Cameron had done, the NCI used oral vitamin C alone. Of course the study failed--its impossible to
achieve the requisite blood levels with oral doses.
The body tightly controls levels of this vitamin by limiting intestinal absorption. Intravenous administration
bypasses this control mechanism, and blood levels rise in a dose-dependent manner. For example, 10 g
of IV vitamin C raises blood levels 25 times higher than the same dose taken orally, and this increases up
to 70-fold as doses get larger. Nevertheless, the flawed study gave conventional doctors an excuse to
shun vitamin C, and to this day they dredge it up as proof that vitamin C is ineffective as a cancer therapy.
Mark Levine, MD, a researcher at the National Institutes of Health has done a great deal of work on the
mechanisms of vitamin C in the treatment of cancer. It was Dr. Levines team that figured out exactly how
vitamin C kills cancer. Vitamin C interacts with iron and other metals in the extracellular fluid (as opposed
to within the cells) to create hydrogen peroxide. Hydrogen peroxide plays a vital signaling role in the
immune system, marshalling white blood cells to sites of injury or disease. In high concentrations, it does
much more. Hydrogen peroxide damages the DNA and mitochondria of aberrant cells, shuts down their
energy supply, and kills them outright. Best of all--and unlike virtually all conventional chemotherapy
drugs that destroy cancer cells--it is selectively toxic. No matter how high the concentration, vitamin C
does not harm healthy cells.
Expectations, Outcomes and Dosage
How much vitamin C is an effective therapeutic dose? Dr. Klenner administered up to 300,000 mg per
day. Generally, he gave 350 to 700 mg per kilogram (2.2 pounds) body weight per day. Dr. Klenner
emphasized that small amounts do not work.
The dosage and route of administration of vitamin C is essential to determine if it has a direct anti-tumour
action or a supportive, antioxidant function. The levels needed to achieve direct tumorcidal effects are at
least 200-1000 micromol/L. To achieve these higher anti-cancer levels, IV doses of 25-50 grams are
required. 50 grams of IV vitamin C can achieve a plasma level of over 14,000 micromol/L. Oral
supplementation is insufficient due to very limited absorption in the digestive tract. Plasma vitamin C
levels peak after 200 mg of oral supplementation, and maximal oral dosing before loose stools occur is
around 4 grams. Oral absorption can be increased if doses are split up during the day, taken with a meal,
or in a sustained released formula. Even when using the same 10 gram dose, intravenous administration
achieved a 50-150 fold greater plasma vitamin C level compared to oral supplementation.
Vitamin C (and in turn hydrogen peroxide) levels peak within 30 minutes after IV administration and then
return to normal within 24 hours. This makes the direct anti-cancer treatment effective for only a short
period time and therefore frequent treatments are needed. The benefit of this is that other therapies can
be used in short succession after vitamin C without fear of interactions. Most integrative oncologists
recommend IV treatments once or twice a week, with oral supplementation on all the other days, for at
least 12 months, with regular lab testing to assess tumour markers and progression.
A number of review papers and case studies by integrative cancer physicians and researchers have
reported improved cancer survival times and quality of life, and even tumour regression in some cases,
after weekly IV vitamin C treatments done consistently over 12 months or longer. It is also important to
note that vitamin C therapy may not work for everyone and for every type of cancer. It is always
recommended to consult your Naturopathic doctor to see if vitamin C therapy is right for you.
FDA Wants IV Vitamin C Banned
Now the FDA is reported to be prohibiting small pharmacies from manufacturing or distributing
injectable vitamin C. This is regardless of the fact that vitamin C is a powerful healing substance that is
great for a lot of health conditions.
Not only is the FDA seeking to eradicate use of IV vitamin C, but they are also working to ban injectable
magnesium chloride and injectable vitamin B complex 100 as well. These substances are used to make
what is called Myers Cocktail, which is used for conditions like chronic fatigue syndrome, hepatitis, AIDS,
mononucleosis, and influenza.
A sure sign of a powerful therapeutic agent is when the FDA tries tot shut it down.
Their reasoning has nothing to do with safety, as vitamin C has continually proven to be one of the least
toxic nutrients in foods and liquid forms have a safe history of use. Instead, the FDA is banning IV vitamin
C because it can't be patented, and can't be taken through the FDA's approval process for a "new drug."
While oral doses can correct deficiencies and maintain antioxidant levels within the body, IV infusions are
required to reach pro-oxidant, anti-cancer plasma levels. To harness maximum benefit, both oral and IV
treatments are needed to take advantage of the wide range of anti-cancer effects. While more studies are
needed, there is a large body of evidence proving that it is a effective vitamin that can play a major role in
an integrative cancer treatment plan.