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Neonatal Sepsis

Neonatal sepsis is a systemic infection in newborn infants younger than 90 days old. It is classified as either early-onset or late-onset disease based on when symptoms begin after birth. Early-onset sepsis occurs within the first week of life and is usually caused by bacteria acquired from the mother's genital tract during delivery. Late-onset sepsis occurs between one week to three months of age and can be caused by bacteria or viruses acquired after birth from the hospital environment or community. The most common causes of both early and late-onset sepsis include Group B Streptococcus and various types of bacteria.

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199 views1 page

Neonatal Sepsis

Neonatal sepsis is a systemic infection in newborn infants younger than 90 days old. It is classified as either early-onset or late-onset disease based on when symptoms begin after birth. Early-onset sepsis occurs within the first week of life and is usually caused by bacteria acquired from the mother's genital tract during delivery. Late-onset sepsis occurs between one week to three months of age and can be caused by bacteria or viruses acquired after birth from the hospital environment or community. The most common causes of both early and late-onset sepsis include Group B Streptococcus and various types of bacteria.

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Annsha Veimern
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© © All Rights Reserved
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NADRAH OTHMAN E5

Neonatal Sepsis [sepsis neonatorum/neonatal septicemia]


Definition :
use to described the systemic response to infection in the
newborn infant -(Nelson pediatric 15th edition)

Sepsis of newborn, septicemia of newborn Pediatrics . A severe


systemic infection of the newborn caused primarily by group B
streptococcus, a bacterium found in the GI and GU tracts
(McGraw-Hill Concise Dictionary of Modern Medicine)-

A blood infection that occur in an infant younger than 90 days


old (University of Maryland Medical Centre)-

Classification :
Time onset
Etiology

How infected?

Early-onset disease
Infection less than 7 days
after birth
1.Group B Streptococcus
(GBS)
2.Enteric bacteria
acquired from maternal
genital tract
3.Escherichia coli
4.Coagulase-negative
Staphylococcus
5.Haemophilus influenza
6.Listeria
monocytogenes
1.Acquired before or
during delivery
associated with
acquisition of
microorganisms from the
mother
2.May from
transplacental infection ,
or an ascending infection
from cervix by organism
that colonise in mother
genitourinary tract

Late-onset disease
Infection within 1 week to
3 months after birth
1.GBS
2.herpes simplex virus
(HSV)
3.enteroviruses
4.E.coli
5.Candida*
6. Coagulase-negative
Staphylococcus (CONS)*
7.Staphylococcus aureus
8.Klebsiella
9.Pseudomonas
1.can be acquired after
delivery in newborn
nursery , NICU or
community
2.vectors for such
colonization may include
vascular or urinary
catheters

*Candida & Coagulase-negative Staphylococcus (CONS) Most common pathogens in late-onset sepsis with
very low-birthweight infants

Reference :
1. Nelson pediatric ; 15th edition ; chapter 98 ; page 528 530
2. William obstetrics ; 23rd edition ; chapter 58 ; page 1220
3. http://medical-dictionary.thefreedictionary.com/neonatal+sepsis
4. http://emedicine.medscape.com/article/978352-overview#showall

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