UNIVERSIDAD DE ZAMBOANGA

School of Allied Medicine (SAM)

Pharmacy Department
Course Syllabus and Topic Outline
Chemistry and Pharmacy of Organic Medicinals
SY: 2016-2017 Second Semester
Course Title

Chemistry and Pharmacy of Organic Medicinals

Course no.

Pharmaceutical Chemistry 2

Credits Units :

5 units credit (3 units lecture, 2 units laboratory

Placement

3rd Year BS Pharmacy, Second Semester

Contact Hours :

3 hours lecture and 6 hours laboratory / week

Course Description:
This course covers the Chemistry and Pharmacy of Organic Medicinals, with emphasis on those
official in the USP and NF and other Standard Compendia.
This is the study the Structure Activity Relationships of Organic Medicinals: including their
physicochemical properties in relation to their biological activity, preparation and/or synthesis, uses
and doses.
SUGGESTED TEACHING APPROACH: The study of Pharmaceutical Chemistry should include:
An introduction to the general properties and functions of drugs;
A general idea of how drugs are designed, developed, and tested;
The use of structural modification, asymmetric synthesis to get the desired optical isomer;
The drug testings made before drugs are introduced to the public;
An awareness of the contribution that science continues to make towards maintaining the health
and well-being of the worlds population.
Prerequisites : Pharm. Chemistry 1 (Inorganic Medicinal & Pharmaceutical Chemistry)
Pharmaceutical Biochemistry
General Objectives: The objectives of the syllabus are to provide students who have exceptional ability and
interest in Chemistry the opportunity to:
(a) Apply the principles of chemistry for an understanding of drug action and design
(b) Understand and apply various analytical techniques to chemical analysis
(c) Be enthused to engage in research and rationalize ethical issues

At the end of the course, the students should be able to:

1. Apply the knowledge, skills, and principles of organic chemistry to medicinal and pharmaceutical chemistry.
2. Learn the Uses, synonyms and other information regarding Organic Medicinal of Pharmaceutical Importance.
3. Discuss the official Organic substances used as therapeutic and diagnostic agents.
4. Manifest an appreciation of the pharmacists social and professional responsibilities in maintaining or restoring the
health of men and animals.
5. Understand the High Moral and Ethical Standards of the Pharmacy Profession.
LEARNING STRATEGIES: Some possible Modes for Learning could include:
For Lecture Module:
Lectures, possibly including Guest Lectures from
Industry and Research
Literature Review of Medicinal Agents
Power Points Presentations
Case Studies / Analyses

For Laboratory Module:

Laboratory Exercises (Synthesis)
Visits to Laboratories & Industries (Optional)
Group & Individual Seat Work
Research Experimental Explorations

While practical work is not a requirement for this course, students would stand to benefit from learning
experiences which complement the study of Pharmaceutical Chemistry.
These include experiences which facilitate the development of skills or enhance familiarity with the processes
associated with drug design and synthesis, and also hands-on experiences for the various spectroscopic, separation
and purification techniques.

SYLLABUS DESIGN:
The syllabus is supposedly based on a 54 lectures hours of teaching and self-directed independent learning
out of Curriculum Time. But the allotted time for the complete discussion of the topics required per term will be about
65 hours, which will be gotten from the laboratory hours and or make Up Classes (to be scheduled).
The subject is pitched at undergraduate Junior Year of BS Pharmacy Curriculum. The students are expected
to perform and comply the following commitments & responsibilities:
1.
2.
3.
4.
5.
6.

Attend the class regularly. Ten absences without valid reasons will be considered dropped.
Submit requirements on time.
Participate actively in class discussion.
Observe the SAM House Rules, Department Policies and Implied Conduct of the Course.
Take the Examinations and Quizzes on time, following strictly NO PERMIT, NO EXAM POLICY.
Develop core values of the Universidad de Zamboanga such as Honesty, Integrity, Morality, Confidentiality,
and Trustworthiness.

Vision, Mission and Objectives of UZ, School of Allied Medicine and Department of Pharmacy.
GRADING SYSTEM:
For LECTURE:
MAJOR EXAMS

For LAB:
%

ITEMS

TIME(Hr
)

Frequency:

60%

Nlt
150

1.5
2.0

4 exams

(PM/MT/PF/Final
)

QUIZZES
TOTAL:

40%
100
%

Nlt 20

1 Q/Ch

3-5 / term

ITEMS

TIME(Hr

Frequency

MAJOR EXAMS

60%

NLT100

1.0-1.5

4 exams

QUIZZES/EXPT
s

40%
Eq. 30s

3Days

3 Expt / term

(AT/P/GWO/Pr)
(RUBRIC Based)

100%

COURSE OUTLINE

Time Allotted

PREMID Coverage

15 hours

Chapter 1:

INTRODUCTION

1 hour

Chapter 2:

Drug Design Strategies

2 hours

Chapter 2.5 Drug Product Development

Chapter 3:

(Optional)

2 hour
2 hours

Chapter 4:

Metabolic Changes of Drugs and

Related Organic Compounds
Biotechnology & Drug Discovery

Chapter 5:

IMMUNOBIOLOGICALS

2 hours

Chapter 6:

Anti-Infective Agents

4 hours

MIDTERM Coverage
Chapter 7:

2 hours

15 hours
ANTIMALARIALS

2 hours

Chapter 8:

Antibacterial Antibiotics

4 hours

Chapter 9:

Antiviral Agents

2 hours

Chapter 10: Antineoplastic Agents

2 hours

Chapter 11: Agents for Diagnostic Imaging

2 hours

Chapter 12: Central Nervous System Depressants

3 hours

PREFINAL Coverage

15 hours

Chapter 13: Dopaminergic Signaling Agents

2 hours

Chapter 14:

2 hours

ANTICONVULSANTS

Chapter 15: Central Nervous System Stimulants

2 hours

Chapter 16: Adrenergic Agents

2 hours

Chapter 17:

2 hours

Cholinergic Drugs & Related Compounds

Chapter 18: Drugs acting on the Renal System

1 hour

Chapter 19: Cardiovascular Agents

4 hours

FINAL Coverage

20 hours

Chapter 20: Hormone-Related Disorders: Non-Steroidal Therapies 2 hours

Chapter 21: Agents Treating Bone Disorders

2 hour

Chapter 22:

2 hour

ANESTHETICS

Chapter 23: Histamine and Antihistaminic Agents

2 hours

Chapter 24:

2 hours

ANALGESICS

Chapter 25: Steroid Hormones and Therapeutically

Related Compounds
Chapter 26: Prostaglandins, Leukotrienes and
Essential and Fatty Acids
Chapter 27: Proteins, Enzymes & Peptide Hormones

2 hours

Chapter 28:

2 hour

VITAMINS

Chapter 29: An Introduction to the Medicinal Chemistry of Herbs

Laboratory

LaboratoryEquipment:
REFERENCES:
(Old Sources)

2 hours
2 hours

2 hours

Synthesis of simple molecules changes in structure

Biological activity testing
Toxicity testing
Standard Chemistry Laboratory Equipment
Burger, Alfred, etal, (1995) Vol.I, Principles and Practice [in Burgers
Medicinal Chemistry and Drug Discovery, Manfred E. Wolff, ed.], New York,
John Wiley and Sons, Inc., xi, 1064 p.
Burger, Alfred, (1970). Medicinal Chemistry, 3rd edition. New York, WileyInterscience, xix, 1712, 4183 p.
Burley, Denis, Joan Clarke and Louis Lasagna,(1993). Pharmaceutical
Medicine, 2nd ed., London, Edward Arnold, 361 p.
Doerge, Robert (Ed.), (1982). Wilson and Gisvolds Textbook of Organic
Medicinal and Pharmaceutical Chemistry, 8th ed., Philadelphia, Lippincott
Co.,
Foye, William O. (1989). Principles of Medicinal Chemistry, 3rd edition,
Philadelphia, Lea and Febiger, 925 p.
Kennewell, Peter and John Taylor, (1993). Modern Medicinal Chemistry.
New York, Ellis Hornwood, 290 p.
Roberts, Stanley and Barry Price, (1985). Medicinal Chemistry: The Role of
Organic Chemistry in Drug Research, London, academic Press, xix, 296 p.
Wolff, Manfred E. and Alfred Burger, (1995). Burgers Medicinal Chemistry
and Drug Discovery, 5th ed., New York, Wiley and Sons, 1354 p.
Gennaro, Alfonso R. (Ed.), (2000). Remingtons Pharmaceutical Sciences,

20th ed., Pennsylvania, Mack Publishing Company, xvi, 2000 p.

Main Reference:

Block, John & Beale, John (Ed) (2011) Wilson and Gisvolds Textbook of
Organic Medicinal and Pharmaceutical Chemistry, 12th ed., 2011,
Philadelphia, Lippincott Co.
Alagarsamy, V. (2014). TEXTBOOK OF MEDICINAL CHEMISTRY. Volume
1 & 2 . 2nd Edition. Reed Elsevier India Private Limited. New Delhi, India.

Additional References: Alagarsamy, V. (2014). TEXTBOOK OF MEDICINAL CHEMISTRY. Volume 1 & 2

(New Books)
2nd Edition. Reed Elsevier India Private Limited. New Delhi, India.
Allen, Jr. Lloyd V., et al. (2013) Remington: The Science and Practice of Pharmacy
22nd Edition. University of the Sciences in Philadelphia. Pharmaceutical Press.
Michigan, USA.
Lemke, Thomas, (2012). Review of Organic Functional Groups: Introduction to Medicinal
Organic Chemistry. 5th Edition. Lippincott Williams & Wilkins - Wolters Kluwer Co.
Philadelphia, USA
Block, John & Beale, John (Ed) (2011) Wilson and Gisvolds Textbook of Organic
Medicinal and Pharmaceutical Chemistry, 12th ed., 2011, Philadelphia, Lippincott
Co. USA
Hendrickson, Randy, (2006) Remington: The Science and Practice of Pharmacy.
21st Edition. University of the Sciences in Philadelphia. Lippincott Williams & Wilkins,
Baltimore, Maryland, USA. 361-384 p. Ch-24
E-Book References :

Seager, Spencer L.; Slabaugh, Michael R. (2014). Chemistry for Today: General,
Organic and Biochemistry. 8th Edition.Brooks/Cole, Cengage Learning Belmont, CA
USA
Atkins, Peter; Jones, Loretta; Laverman, Leroy. (2013). Chemical Principles. The
Quest For Insight. 6th Edition. W. H. Freeman and Company. New York, USA.
Allen, Jr. Lloyd V. (editor) (2013). Remington: An Introduction to Pharmacy. Royal
Pharmaceutical Society of Great Britain 2012. Pharmaceutical Press London, UK.
Felton, Linda A. (editor). (2013). Remington: Essentials of Pharmaceutics. 1st Edition.
Royal Pharmaceutical Society of Great Britain 2012. Pharmaceutical Press London,
UK
Lemke, Thomas, (2012). Review of Organic Functional Groups: Introduction to Medicinal
Organic Chemistry. 5th Edition. Lippincott Williams & Wilkins - Wolters Kluwer Co.
Philadelphia, USA.
Cairns, Donald. (2012). Essentials of Pharmaceutical Chemistry. 4th Edition.
Pharmaceutical Press: Royal Pharmaceutical Society of Great Britain, UK.
Alagarsamy, V. (2010). TEXTBOOK OF MEDICINAL CHEMISTRY. Volume 1 & 2
1st Edition. Reed Elsevier India Private Limited. New Delhi, India.
Hendrickson, Randy, (2006) Remington: The Science and Practice of Pharmacy
21st Edition.University of the Sciences in Philadelphia. Lippincott Williams & Wilkins,
Baltimore, Maryland, USA. 361-384 p. Ch-24

Pharmacy Reviewers: ACE Learning Specialist Review Lecture Compilation. June 2015.
BREX Pharmacy Review Program for Local Pharmacy and Foreign
Pharmacy 2013 Edition. March 2014
BREX Pharmacy Review Program for Local Pharmacy and Foreign
Pharmacy 2011 Edition. March 2012
PACOP Comprehensive Pharmacy Reviewer 2012 Edition. June 2012
University of the Philippines (UP) Manila Comprehensive Pharmacy
Reviewer January 2012 Edition. March 2012
San Carlos University Comprehensive Pharmacy Reviewer March 2011
INRESS Review Center Comprehensive Pharmacy Reviewer May 1998.
South Western University Pharmaceutical Chemistry Review Notes, March 1998.
Enhanced by:

Reviewed by:

BEN-FRAZIER U. SABTULA, RPh, MSPharm (CAR)

Instructor

MARY BELEN T. MOGOL, RPh. MS Pharm, Ph.D

Program Head Pharmacy Department

Noted by:

Approved by:

MADELYN F. CANDIDO, MLS, Ph.D

Chief Librarian

NENITA SJ. EUSTAQUIO, RMT, MSMT

DEAN School of Allied Medicine
Adapted from:

Philippine Association of Colleges of Pharmacy (PACOP)

Revision #-07. November, 2016