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Lampira N (Perhitungan) : Eliminasi Absorbsi

1. The document calculates pharmacokinetic parameters for a drug including elimination rate constant (k), absorption rate constant (Ka), half-life (t1/2), time to maximum plasma concentration (tmax), maximum plasma concentration (Cmax), area under the plasma concentration-time curve from time 0 to t hours (AUC0-t), and volume of distribution (Vd). 2. It finds that k = 0.085/hr, Ka = 0.348/hr, t1/2 = 8.153 minutes, tmax = 5.361 minutes, Cmax = 39,758 μg/mL, AUC0-13.74 = 161.647 μg*min/mL, and

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Rifal Agustira
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33 views5 pages

Lampira N (Perhitungan) : Eliminasi Absorbsi

1. The document calculates pharmacokinetic parameters for a drug including elimination rate constant (k), absorption rate constant (Ka), half-life (t1/2), time to maximum plasma concentration (tmax), maximum plasma concentration (Cmax), area under the plasma concentration-time curve from time 0 to t hours (AUC0-t), and volume of distribution (Vd). 2. It finds that k = 0.085/hr, Ka = 0.348/hr, t1/2 = 8.153 minutes, tmax = 5.361 minutes, Cmax = 39,758 μg/mL, AUC0-13.74 = 161.647 μg*min/mL, and

Uploaded by

Rifal Agustira
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© © All Rights Reserved
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LAMPIRA

N (Perhitungan)

1. K eliminasi (K) K absorbsi


Hasil Regresi Orde I Hasil Regresi Orde 0
a = 1,942 a = 17,54
b = -0,037 b = 3,975
r = -0,9998 r = 0,965
Persamaan Garis
y = -0,037x + 1,942
k = 2,303 x (-0,037)
= 0,085
2. K absorbsi (Ka)
y = -0,037x + 1,942, substitusi nilai t = 2 , 4 dan 6
y1 = -0,037(2) + 1,942 = 1,868
y2 = -0,037(4) + 1,942 = 1,794
y3 = -0,037(6) + 1,942 = 1,720
Kemudian hasilnya di Antilog-kan :

Regresikan antara log dengan waktu, sehingga diperoleh :


A = 2,006, b = -0,151, dan r = -0,9986
Karena mengikuti orde I, maka :
Ka = -b x 2,303
= -(-0,151) x 2,303
= 0,348
3. Waktu paruh (t )
0,693
t =
k

0,693

0,085

8,153 menit

( Ka/k )
t max=
4. (Kak )
(0,340/0,085)

(0,3400,085)

(4,094)

(0,263)

5,361 menit

F x Do x Ka
Vd=
5. Antilog a( Kak )

0,85 x 500.000 x 0,348



Antilog x 1,942(0,3480,085)

147900

23,012

6427,082 mL

k. t max Ka .t max
e e
F x Do x Ka
6. Cp max= x )
Vd ( Kak)

e(0,085 x 5,361)e(0,348 x 5,361)


0,85 x 500.000 x 0,348
x )
6427,082( 0,3480,085)

e 0,456e1,866
147900
x )
1690,523

1,5780,155
147900
x )
1690,523

147900
x 1,423
1690,523
124,508 g /mL

( A . ek. t max
) B . eKa .t max
Cp max = - )

Dimana, A = Antilog a (fase eliminasi)


= Antilog 1,942
= 87,498
B = Antilog a (fase Absorbsi)
= Antilog 2,006
= 101,391

k . t max Ka .t max
A .e B.e
Cp max = - )

87,498 . e(0,085 x5,361) 101,391. e(0,348 .5,361)


= )- )

87,498 x 0,634 101,391 x 0,155


= )- )

= 55,47415,716

= 39,758 g/mL
t Cp n
7. [ AUC ] tn= k

13,74

0,085

161,647 gmenit/mL

t
[ AUC ] tn
AUC ekstrapolasi= x 100
8. t
[ AUC ] tn

161,647
x 100
588,14

27,484

t F. D
9. [ AUC ] = k . Vd

0,85 x 500.000

0,085 x 6427,082

42500

546,302

777,958 g menit /mL

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