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Futile Cycle

1) A futile cycle occurs when two metabolic pathways run simultaneously in opposite directions, converting a substrate back and forth without any overall effect other than dissipating energy as heat. 2) An example is the simultaneous occurrence of glycolysis and gluconeogenesis, where glucose is converted to pyruvate and back to glucose, consuming ATP without purpose. 3) Futile cycles may help regulate metabolism and generate heat to maintain homeostasis.

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393 views2 pages

Futile Cycle

1) A futile cycle occurs when two metabolic pathways run simultaneously in opposite directions, converting a substrate back and forth without any overall effect other than dissipating energy as heat. 2) An example is the simultaneous occurrence of glycolysis and gluconeogenesis, where glucose is converted to pyruvate and back to glucose, consuming ATP without purpose. 3) Futile cycles may help regulate metabolism and generate heat to maintain homeostasis.

Uploaded by

Ruvini Buddhika Amarasinghe
Copyright
© © All Rights Reserved
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Futile cycle

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A futile cycle, also known as a substrate cycle, occurs when two metabolic pathways run
simultaneously in opposite directions and have no overall effect other than to dissipate
energy in the form of heat.[1] For example, if glycolysis and gluconeogenesis were to be
active at the same time, glucose would be converted to pyruvate by glycolysis and then
converted back to glucose by gluconeogenesis, with an overall consumption of ATP.[2]
Futile cycles may have a role in metabolic regulation, where a futile cycle would be a
system oscillating between two states and very sensitive to small changes in the activity
of any of the enzymes involved.[3] The cycle does generate heat, and may be used to
maintain thermal homeostasis, for example in the brown adipose tissue of young
mammals, or to generate heat rapidly, for example in insect flight muscles and in
hibernating animals during periodical arousal from torpor. It has been reported that the
glucose metabolism substrate cycle is not a futile cycle but a regulatory process. For
example, when energy is suddenly needed, ATP is replaced by AMP, a much more
reactive adenine.

Example
The simultaneous carrying out of glycolysis and gluconeogenesis is an example of a
futile cycle, represented by the following equation:

For example, during glycolysis, fructose-6-phosphate is converted to fructose-1,6-


bisphosphate in a reaction catalysed by the enzyme phosphofructokinase 1 (PFK-1).

ATP + fructose-6-phosphate Fructose-1,6-bisphosphate + ADP

But during gluconeogenesis (i.e. synthesis of glucose from pyruvate and other
compounds) the reverse reaction takes place, being catalyzed by fructose-1,6-
bisphosphatase (FBPase-1).

Fructose-1,6-bisphosphate + H2O fructose-6-phosphate + Pi

Giving an overall reaction of:


ATP + H2O ADP + Pi + Heat

That is, hydrolysis of ATP without any useful metabolic work being done. Clearly, if
these two reactions were allowed to proceed simultaneously at a high rate in the same
cell, a large amount of chemical energy would be dissipated as heat. This uneconomical
process has therefore been called a futile cycle.[

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