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Epithelial Changes in The Oral Mucosa Resulting From A Variation in Hormone Stimulus

Higher levels of estrogen are associated with increased maturation and keratinization of oral mucosa, while high progesterone levels are associated with retarded maturation. The study examined oral smears from 360 women in 5 groups based on hormone levels: 1) high progesterone oral contraceptives, 2) postmenopausal estrogen therapy, 3) no hormones, 4) mid-cycle high estrogen, 5) early/late cycle high progesterone. Smears from high estrogen groups showed more superficial and keratinized cells, while high progesterone smears had more intermediate cells and fewer keratinized cells, indicating estrogen promotes and progesterone inhibits oral mucosal maturation.

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Firda Handayani
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27 views

Epithelial Changes in The Oral Mucosa Resulting From A Variation in Hormone Stimulus

Higher levels of estrogen are associated with increased maturation and keratinization of oral mucosa, while high progesterone levels are associated with retarded maturation. The study examined oral smears from 360 women in 5 groups based on hormone levels: 1) high progesterone oral contraceptives, 2) postmenopausal estrogen therapy, 3) no hormones, 4) mid-cycle high estrogen, 5) early/late cycle high progesterone. Smears from high estrogen groups showed more superficial and keratinized cells, while high progesterone smears had more intermediate cells and fewer keratinized cells, indicating estrogen promotes and progesterone inhibits oral mucosal maturation.

Uploaded by

Firda Handayani
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Epithelial changes in the oral mucosa resulting

from a variation in hormone stimulus


J Oral Med. 1978 Jul-Sep;33(3):86-9.

Croley TE, Miers C.

Abstract

PIP:

The relative influence of progesterone and estrogen on oral mucosal development was investigated
and increased estrogen levels were associated with maturation and keratinization or oral mucosa
while high levels of progesterone were associated with retarded maturation. The relationships were
significant at the 0.05 level. The study population consisted of 360 women who had normal estrous
cycles and who were either patients or students at a local dental clinic. For each woman, a
questionnaire was used to obtain information in regard to age, contraceptive use, hormone therapy,
and menstrual history and scrappings were made of the buccal gingiva at the second premolar and
the buccal mucosa at Stenson's papilla. Using the questionnaire information, each woman was
assigned to 1 of 5 groups on the basis of hormone status. The groups were 1) women using oral
contraceptives with a high progesterone component; 2) postmenopausal women being treated with
estrogen; 3) postmenopausal women not receiving hormones; 4) women who were sampled during
the 11-18 day of their menstrual cycle when estrogen influences prevail; and 5) women who were
sampled during the days 1-10 or 19-28 of their cycle when progesterone influences prevail. The
smears were then examined cytologically by a certified diagnostic cytologist who was aware of the
patient's medical history. A consistent pattern was found in the buccal smears; the smears of those
patients with high estrogen levels exhibited an increased number of superficial and keritanized
epithelial cells, while those with higher progesterone levels exhibited an increase in the number of
intermediate epithelial cells and a decrease in the number of keritanized cells. Tables comparing the 5
groups using the one-way test of variance and photographs of smears displaying cell maturation and
lack of complete cell maturation are included.

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