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Piperacillin

Piperacillin/tazobactam (brand name Zosyn) is a beta-lactam antibiotic used to treat moderate to severe infections caused by piperacillin-resistant and tazobactam-susceptible bacteria. It works by interfering with bacterial cell wall synthesis. Common side effects include diarrhea, nausea, vomiting, and hypersensitivity reactions. Nursing responsibilities include checking the doctor's order, assessing the patient's history and monitoring for side effects, administering the drug correctly, educating the patient, and monitoring the patient after administration.

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1K views

Piperacillin

Piperacillin/tazobactam (brand name Zosyn) is a beta-lactam antibiotic used to treat moderate to severe infections caused by piperacillin-resistant and tazobactam-susceptible bacteria. It works by interfering with bacterial cell wall synthesis. Common side effects include diarrhea, nausea, vomiting, and hypersensitivity reactions. Nursing responsibilities include checking the doctor's order, assessing the patient's history and monitoring for side effects, administering the drug correctly, educating the patient, and monitoring the patient after administration.

Uploaded by

myer pasandalan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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DRUG STUDY

GENERIC NAME: Piperacillin / Tazobactam


Brand name: Zosyn
Drug Classification: Antiinfective; Beta-lactam antibiotic; Anti-pseudomonal penicillin

DOSAGE, ROUTE, SIDE EFFECTS and


FREQUENCY (prescribed and INDICATION MECHANISM OF ADVERSE REACTIONS
recommended) ACTION (by system)

It is similar to that of
Treatment of moderate to CNS: headache, insomnia,
other penicillins.
severe appendicitis, fever
Interfere with bacterial
uncomplicated and
cell wall synthesis
complicated skin and skin GI: diarrhea, nausea,
promotes loss of constipation, vomiting,
structure infections,
membrane integrity and nosocomial or community- pseudomembranous colitis
leads to death of the acquired pneumonia caused
organism. piperacillin-resistant, SKIN: hypersensitivity
reactions ,rash, pruritus
piperacillin/tazobactam
susceptible, beta-lactamase-
producing bacteria.

NURSING RESPONSIBILITIES
CONTRAINDICATION/S (at least 10)
Before:
Hypersensitivity to penicillins, > check the doctor’s order
cephalosphorins, or other > assess for history: hepatic and renal impairment, lactation, pregnancy
> assess for physical cues: skin status, LFTs, renal function tests, culture
drugs. Safety in children < 12
of affected area
years old, pregnancy, lactation. - > Obtain specimen for culture and sensitivity prior to first dose of the
drug; start drug pending results. Periodic CBC with differential, platelet
count, Hgb & Hgt, and serum electrolytes.

During:
> administer the right drug
> explain to the patient about the importance and purpose of the drug
> administer at the right time and right dosage
> avoid alcohol while taking this drug and for 3 days after because severe
reactions often occur
> discontinue if hypersensitivity reaction occurs

After:
> document and record.
- >Monitor for hypersensitivity response; discontinue drug and notify physician if
allergic response noted.
- Monitor for hemorrhagic manifestations because high dose may induce
coagulation abnormalities.
- Instruct family/significant others to report significant, unexplained diarrhea.

Patient’s Name / Room No.

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