EUROPEAN

RESPIRATORY CONTENTS
journal VOLUME 43 / NUMBER 1 / JANUARY 2014

EDITORIALS
1 The ambition of the European Respiratory Journal: chapter 2
Marc Humbert
3 Respiratory diseases in the world: one voice “united for lung health”
Peter J. Barnes, Francesco Blasi, Brian Ward, Elin Reeves and Klaus F. Rabe
6 Safety of 2 agonists: a 50-year debate closed?
Jean Bousquet, Arnaud Bourdin, Pascal Demoly
10 Six simple questions contra the delay
Felix C. Ringshausen, Tobias Welte and Albert Nienhaus
12 Pulmonary hypertension in hypoventilation syndromes
Robert Naeije
16 Towards early detection of pulmonary hypertension: a call to arms
Kenneth Whyte
20 Newborn screening and carrier screening for cystic fibrosis: alternative or complementary?
Carlo Castellani and John Massie
24 Bacille Calmette–Guérin vaccination: the current situation in Europe?
Masoud Dara, Colleen D. Acosta, Valiantsin Rusovich, Jean Pierre Zellweger, Rosella Centis and
Giovanni Battista Migliori on behalf of the WHO EURO Childhood Task Force members

ORIGINAL ARTICLES
COPD
36 Prior cardiovascular disease increases long-term mortality in COPD patients with pneumonia
Oriol Sibila, Eric M. Mortensen, Antonio Anzueto, Elena Laserna and Marcos I. Restrepo
43 Serum uric acid as predictor of mortality and future exacerbations of COPD
Konstantinos Bartziokas, Andriana I. Papaioannou, Stelios Loukides, Alexandros Papadopoulos,
Aikaterini Haniotou, Spyridon Papiris and Konstantinos Kostikas

54 COPD prognosis in relation to diagnostic criteria for airflow obstruction in smokers

Reinier P. Akkermans, Marion Biermans, Bas Robberts, Gerben ter Riet, Annelies Jacobs, Chris van Weel,
Michel Wensing and Tjard Schermer
CME article 64 Aspergillus fumigatus during stable state and exacerbations of COPD
Mona Bafadhel, Susan Mckenna, Joshua Agbetile, Abbie Fairs, Dhananjay Desai, Vijay Mistry,
Joseph P. Morley, Mitesh Pancholi, Ian D. Pavord, Andrew J. Wardlaw, Catherine H. Pashley and
Christopher E. Brightling

72 Umeclidinium in patients with COPD: a randomised, placebo-controlled study

Roopa Trivedi, Nathalie Richard, Rashmi Mehta and Alison Church

82 Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema

Takeo Ishii, Raja T. Abboud, Alison M. Wallace, John C. English, Harvey O. Coxson, Richard J. Finley,
Karey Shumansky, Peter D. Paré and Andrew J. Sandford

Asthma
92 Prediction of new-onset asthma and nasal allergy by skin prick test and RAST in a cohort of adults
Kerstin Gallmeier, Eva Becker, Anne Kirsten, Gabriele Wölke, Olaf Manuwald, Heike Meyer,
Helgo Magnussen, Dennis Nowak and Joachim Heinrich

103 Safety of formoterol in asthma clinical trials: an update

Malcolm R. Sears and Finn Radner

Paediatric pneumology
115 Spirometer-controlled cine magnetic resonance imaging used to diagnose tracheobronchomalacia in
paediatric patients
Pierluigi Ciet, Piotr Wielopolski, Rashindra Manniesing, Sandra Lever, Marleen de Bruijne,
Giovanni Morana, Pier Carlo Muzzio, Maarten H. Lequin and Harm A.W.M. Tiddens
ORIGINAL ARTICLES (CONTINUED)
Cystic fibrosis
125 Factors associated with FEV1 decline in cystic fibrosis: analysis of the ECFS Patient Registry
Eitan Kerem, Laura Viviani, Anna Zolin, Stephanie MacNeill, Elpis Hatziagorou, Helmut Ellemunter,
Pavel Drevinek, Vincent Gulmans, Uros Krivec and Hanne Olesen on behalf of the ECFS Patient Registry
Steering Group

Sleep medicine
134 Social consequences of sleep disordered breathing on patients and their partners: a controlled national
study
Poul Jennum, Rikke Ibsen and Jakob Kjellberg

145 Sleep apnoea, sleepiness, inflammation and insulin resistance in middle-aged males and females
Ilia Kritikou, Maria Basta, Alexandros N. Vgontzas, Slobodanka Pejovic, Duanping Liao,
Marina Tsaoussoglou, Edward O. Bixler, Zacharias Stefanakis and George P. Chrousos

Pulmonary vascular diseases

156 Functional impact of pulmonary hypertension due to hypoventilation and changes under noninvasive
ventilation
Matthias Held, Johanna Walthelm, Stefan Baron, Christine Roth and Berthold Jany

Tuberculosis
166 Short- and long-term mortality and causes of death in HIV/tuberculosis patients in Europe
Daria N. Podlekareva, Alexander M. Panteleev, Daniel Grint, Frank A. Post, Jose M. Miro, Mathias Bruyand,
Hansjakob Furrer, Niels Obel, Enrico Girardi, Anna Vasilenko, Marcelo H. Losso, Alejandro Arenas-Pinto,
Joan Caylá, Aza Rakhmanova, Indra Zeltina, Anne Marie Werlinrud, Jens D. Lundgren, Amanda Mocroft,
Ole Kirk and the HIV/TB study group
178 Predicting Mycobacterium tuberculosis in patients with community-acquired pneumonia
Rodrigo Cavallazzi, Timothy Wiemken, Diana Christensen, Paula Peyrani, Francesco Blasi, Gur Levy,
Stefano Aliberti, Robert Kelley, Julio Ramirez and the Community-Acquired Pneumonia Organization
(CAPO) Investigators
185 Sputum induction to aid diagnosis of smear-negative or sputum-scarce tuberculosis in adults in
HIV-endemic settings
Jonathan G. Peter, Grant Theron, Nevanda Singh, Avani Singh and Keertan Dheda

Lung function and HIV infection

195 Contributors to diffusion impairment in HIV-infected persons
Matthew R. Gingo, Jiayan He, Catherine Wittman, Carl Fuhrman, Joseph K. Leader, Cathy Kessinger,
Lorrie Lucht, William A. Slivka, Yingze Zhang, Deborah K. McMahon, Frank C. Sciurba and Alison Morris

Interstitial lung diseases

204 Automated quantification of radiological patterns predicts survival in idiopathic pulmonary fibrosis
Fabien Maldonado, Teng Moua, Srinivasan Rajagopalan, Ronald A. Karwoski, Sushravya Raghunath,
Paul A. Decker, Thomas E. Hartman, Brian J. Bartholmai, Richard A. Robb and Jay H. Ryu

Acute lung injury and critical care

213 Thenar oxygen saturation during weaning from mechanical ventilation: an observational study
Guillem Gruartmoner, Jaume Mesquida, Jordi Masip, Maria L. Martínez, Ana Villagra, Francisco Baigorri,
Michael R. Pinsky and Antonio Artigas

Bronchiolitis
221 Calcineurin inhibitors in bronchiolitis obliterans syndrome following stem cell transplantation
Katrin E. Hostettler, Jörg P. Halter, Sabine Gerull, Didier Lardinois, Spasenija Savic, Michael Roth
and Michael Tamm

Lung cancer
233 Endobronchial ultrasound-guided cryobiopsies in peripheral pulmonary lesions: a feasibility study
Maren Schuhmann, Korkut Bostanci, António Bugalho, Arne Warth, Philipp A. Schnabel, Felix J.F. Herth
and Ralf Eberhardt

240 Second-line therapy in elderly patients with advanced nonsmall cell lung cancer
Elisabeth Quoix, Virginie Westeel, Lionel Moreau, Eric Pichon, Armelle Lavolé, Jérome Dauba,
Didier Debieuvre, Pierre Jean Souquet, Laurence Bigay-Game, Eric Dansin, Michel Poudenx, Olivier
Molinier, Fabien Vaylet, Denis Moro-Sibilot, Denis Herman, Helene Sennelart, Jean Tredaniel,
Bertrand Mennecier, Franck Morin, Laurence Baudrin, Bernard Milleron and Gérard Zalcman and on behalf
of Intergroupe Francophone de Cancérologie Thoracique
REVIEWS
250 Ambient air pollution: a cause for COPD?
Tamara Schikowski, Inga C. Mills, H. Ross Anderson, Aaron Cohen, Anna Hansell, Francine Kauffmann,
Ursula Krämer, Alessandro Marcon, Laura Perez, Jordi Sunyer, Nicole Probst-Hensch and Nino Künzli

264 The plasmacytoid dendritic cell: at the cross-roads in asthma

Jason P. Lynch, Stuart B. Mazzone, Matthew J. Rogers, Jaisy J. Arikkatt, Zhixuan Loh, Antonia L. Pritchard,
John W. Upham and Simon Phipps
276 The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical
significance
Ellen L. Burnham, William J. Janssen, David W.H. Riches, Marc Moss and Gregory P. Downey

AGORA
Research letters
286 ERS/WHO Tuberculosis Consilium: reporting of the initial 10 cases
Lia D’Ambrosio, Marina Tadolini, Stephane Dupasquier, Simon Tiberi, Rosella Centis, Masouda Dara,
Francesco Blasi and Giovanni Battista Migliori

289 Bedaquiline in MDR/XDR-TB cases: first experience on compassionate use

Simon Tiberi, Saverio De Lorenzo, Rosella Centis, Pietro Viggiani, Lia D’Ambrosio and
Giovanni Battista Migliori

292 Extensively drug-resistant tuberculosis: early access to bedaquiline for a UK patient

Clare van Halsema, Susan Humphreys and Alec Bonington

295 Tumour necrosis factor receptor-75 and risk of COPD exacerbation in the azithromycin trial
Prescott G. Woodruff, Wissam Chatila, John E. Connett, Gerard J. Criner, Jeffrey L. Curtis,
Mark T. Dransfield, MeiLan K. Han, Stephen C. Lazarus, Nathaniel Marchetti, Thomas J. Rogers,
Paul D. Scanlon, Don D. Sin, Helen Voelker, Christine Wendt and Richard K. Albert for the COPD Clinical
Research Network

298 Pulmonary embolism risk stratification: where are we heading?

Luis Paiva, Sérgio Barra and Rui Providência

300 Smoking resumption after lung transplantation: standardised screening and importance for
long-term outcome
David Ruttens, Stijn E. Verleden, Pieter C. Goeminne, Katrien Poels, Elly Vandermeulen, Lode Godderis,
Dirk E. Van Raemdonck, Bart M. Vanaudenaerde, Jeroen Vanoirbeek, Robin Vos and Geert M. Verleden

303 Can diaphragm pacing improve gas exchange? Insights from quadriplegic patients
Jésus Gonzalez-Bermejo, Capucine Morélot-Panzini, Marjolaine Georges, Alexandre Demoule and
Thomas Similowski

Correspondence
307 Predicting an accelerated lung function decline in smokers: is there a proper threshold?
Firdaus A.A. Mohamed Hoesein and Pieter Zanen; Reinier P. Akkermans, Marion Biermans, Bas Robberts,
Gerben ter Riet, Annelies Jacobs, Chris van Weel, Michel Wensing and Tjard Schermer

310 The TLNO/TLCO ratio in pulmonary function test interpretation

Colin Borland; J. Michael B. Hughes and Ivo van der Lee

312 Integrating drug concentrations and minimum inhibitory concentrations with Bayesian-dose optimisation
for multidrug-resistant tuberculosis
Shashikant Srivastava and Tawanda Gumbo

313 MicroRNAs and pulmonary hypertension

Matthias Brock, Silvia Ulrich and Lars Christian Huber

f,h,j,l MEETING CALENDAR

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