Tuberculosis (TB) Is An
Tuberculosis (TB) Is An
tuberculosis (MTB).[1] Tuberculosis generally affects the lungs, but can also affect other parts of the
body.[1] Most infections do not have symptoms, in which case it is known as latent
tuberculosis.[1] About 10% of latent infections progress to active disease which, if left untreated, kills
about half of those infected.[1] The classic symptoms of active TB are a chronic cough with blood-
containing sputum, fever, night sweats, and weight loss.[1] The historical term "consumption" came
about due to the weight loss.[4] Infection of other organs can cause a wide range of symptoms.[5]
Tuberculosis is spread through the air when people who have active TB in their lungs cough, spit,
speak, or sneeze.[1][6] People with latent TB do not spread the disease.[1] Active infection occurs more
often in people with HIV/AIDS and in those who smoke.[1] Diagnosis of active TB is based on chest
X-rays, as well as microscopic examination and culture of body fluids.[7]Diagnosis of latent TB relies
on the tuberculin skin test (TST) or blood tests.[7]
Prevention of TB involves screening those at high risk, early detection and treatment of cases,
and vaccination with the bacillus Calmette-Guérin (BCG) vaccine.[8][9][10] Those at high risk include
household, workplace, and social contacts of people with active TB.[10] Treatment requires the use of
multiple antibiotics over a long period of time.[1] Antibiotic resistance is a growing problem with
increasing rates of multiple drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant
tuberculosis (XDR-TB).[1]
Presently, one-third of the world's population is thought to be infected with TB.[1] New infections
occur in about 1% of the population each year.[11] In 2016, there were more than 10 million cases of
active TB which resulted in 1.3 million deaths.[3] This makes it the number one cause of death from
an infectious disease.[3] More than 95% of deaths occurred in developing countries, and more than
50% in India, China, Indonesia, Pakistan, and the Philippines.[3] The number of new cases each year
has decreased since 2000.[1] About 80% of people in many Asian and African countries test positive
while 5–10% of people in the United States population test positive by the tuberculin
test.[12] Tuberculosis has been present in humans since ancient times.[13]
Symptoms: