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Aztreonam

Aztreonam is an intravenous antibiotic administered every 8 hours that binds to bacterial cell walls causing death, with potential side effects including seizures, diarrhea, rash, and allergic reactions. It requires monitoring for signs of infection and hypersensitivity reactions, as well as bowel function for Clostridium difficile-associated diarrhea. Nursing considerations include administration by IV push over 3-5 minutes or intermittent infusion over 20-60 minutes after reconstitution and dilution.

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325 views2 pages

Aztreonam

Aztreonam is an intravenous antibiotic administered every 8 hours that binds to bacterial cell walls causing death, with potential side effects including seizures, diarrhea, rash, and allergic reactions. It requires monitoring for signs of infection and hypersensitivity reactions, as well as bowel function for Clostridium difficile-associated diarrhea. Nursing considerations include administration by IV push over 3-5 minutes or intermittent infusion over 20-60 minutes after reconstitution and dilution.

Uploaded by

HannahShaeHayes
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Medication aztreonam

Name
Trade Name Azactam
Generic Name aztreonam
Usual Dose IV: (Adults) CCr 10–30 mL/min– 1–2 g initially, then 50% of usual dosage at
usual interval; CCr <10 mL/min– 500 mg–2 g initially, then 25% of usual
dosage at usual interval (1/8 of initial dose should also be given after each
hemodialysis session).
Ordered Dose 1 grm
Route & IV Q8hr
Frequency
Action of Binds to the bacterial cell wall membrane, causing cell death.
Medication Therapeutic Effect(s):
Bactericidal action against susceptible bacteria.

Side Effects CNS: SEIZURES


EENT: nasal congestion (inhalation), nasopharyngeal pain (inhalation)
CV: chest discomfort (inhalation)
GI: CLOSTRIDIUM DIFFICILE-ASSOCIATED DIARRHEA (CDAD), abdominal pain
(inhalation), altered taste, diarrhea, nausea, vomiting
Resp: cough (inhalation), wheezing (inhalation), bronchospasm (inhalation)
Derm: rash
Local: pain at IM site, phlebitis at IV site
Misc: ALLERGIC REACTIONS INCLUDING ANAPHYLAXIS, fever (inhalation),
superinfection
Nursing  Assess for infection (vital signs; wound appearance, sputum, urine,
Considerations and stool; WBC) at beginning of and throughout therapy.
 Obtain a history before initiating therapy to determine previous use
of and reactions to penicillins and cephalosporins. Patients allergic to
these drugs may exhibit hypersensitivity reactions to aztreonam.
However, aztreonam can often be used in these patients.
 Obtain specimens for culture and sensitivity before initiating
therapy. First dose may be given before receiving results.
 Assess respiratory status prior to and following inhalation therapy.
 Observe for signs and symptoms of anaphylaxis (rash, pruritus,
laryngeal edema, wheezing). Notify the health care professional
immediately if these occur.
 Monitor bowel function. Report diarrhea, abdominal cramping,
fever, and bloody stools to health care professional promptly as a
sign of Clostridium difficile-associated diarrhea (CDAD). May begin
up to several weeks following cessation of therapy.

IV Push: Reconstitute 15 mL vial with 6–10 mL of sterile water for injection.


Rate: Administer slowly over 3–5 min by direct injection or into tubing of a
compatible solution.
Intermittent Infusion: Reconstitute 15 mL vial with at 3 mL of Sterile Water
for Injection. Diluent: Dilute further with 0.9% NaCl, Ringer's or LR, D5W,
D10W, D5/0.9% NaCl, D5/0.45% NaCl, D5/0.2% NaCl, D5/LR, or sodium
lactate. Concentration: Do not exceed 50 mg/mL. Solution is stable for 48 hr
at room temperature and 7 days if refrigerated. Solutions range from
colorless to light, straw yellow or may develop a pink tint upon standing;
this does not affect potency.
Rate: Infuse over 20–60 min.

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