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Eliminasi Distribusi Absorbsi: T CP C Terminal c1 Residual C Distribusi c2 Residual AUC

The document contains pharmacokinetic data from a drug administration study including concentration over time values, absorption and elimination rate constants, AUC, Cmax, Tmax, half-life and other values. It includes graphs of concentration versus time for absorption, elimination, and an overall drug profile. Kinetic parameter values were estimated from the concentration time data.

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Dewi Patni
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27 views5 pages

Eliminasi Distribusi Absorbsi: T CP C Terminal c1 Residual C Distribusi c2 Residual AUC

The document contains pharmacokinetic data from a drug administration study including concentration over time values, absorption and elimination rate constants, AUC, Cmax, Tmax, half-life and other values. It includes graphs of concentration versus time for absorption, elimination, and an overall drug profile. Kinetic parameter values were estimated from the concentration time data.

Uploaded by

Dewi Patni
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as XLSX, PDF, TXT or read online on Scribd
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t cp c terminal c1 residual c distribusi c2 residual AUC ke

0 0 Err:509 Err:509 51.604 Err:509 3.37 kd


0.5 13.48 19.107417268 -5.62741727 43.34100519 48.9684224532 8.87025 ka
1 22.001 19.031140254 2.969859746 36.40110709 33.4312473487 25.4445 auc total
2 28.888 18.879498508 10.00850149 25.67709088 15.6685893866 87.981 auc tak hi
5 29.766 18.431784601 11.3342154 9.012380011 2.3218353887 26.453 F
6 23.14 18.284918571 4.855081429 6.357270947 1.5021895182 124.14 Do
12 18.24 17.427973684 0.812026316 0.783173667 0.0288526491 206.16 t max
24 16.12 15.832686965 0.287313035 0.01188592 0.2754271153 346.68 cmax
48 12.77 13.066825299 -0.2968253 2.73768E-06 0.2968280367 279.96 cl
72 10.56 10.784140669 -0.22414067 6.30568E-10 0.2241406693 421.3872 VD
120 6.9978 7.3454171245 -0.34761712 3.34526E-17 0.3476171245 t 1/2
TOTAL 1530.446
TAK HINGGA 2405.171
eliminasi
100 distribusi ab
100 100
f(x) = 71.726501035
10 R² = 1
10 f(x) = 51.6042091702 exp( - 0.3491817531 x )
f(x) = 19.1841920379 exp( - 0.0083853836 x ) 10
R² = 0.9996268944 R²
1
= 0.9650677986

1 0.1
40 50 60 70 80 90 100 110 120 130 4 5 6 7 8 9 10 11 12 13 1
0 0.2 0.4
0.008 detik-1
0.349 detik-1
0.75 detik-1 profil
1530.446 mg/L.detik 35
2405.171 mg/L.detik
30
1.453
25
10 mg
11.30499 detik 20
18.50855 mg/L 15
0.009494 L/detik 10
0.755144 L
5
86.625 detik
0
0 20 40 60 80 100 120 140

absorbsi
100
f(x) = 71.726501035 exp( - 0.7633692773 x )
R² = 1
10
17.52514
0.998156
1 0.014745
0 0.2 0.4 0.6 0.8 1 1.2
t cp c terminal c residual AUC ke 0.02 detik-1
0 0 14.923 14.923 1.575 ka 2.5 detik-1
0.5 6.3 15.07297864 8.7729786434 5.6875 F 0.5
1 16.45 15.2244646 1.2255354028 9.665 Do 10 mg/hari
1.5 22.21 15.37747301 6.8325269898 11.1275 AUC total 661.69 mg/L.detik
2 22.3 15.53201918 6.7679808167 21.9 AUC tak hi 829.19 mg/L.detik
3 21.5 15.84578678 5.6542132159 162.45 t 1/2 34.65 detik
12 14.6 18.97085107 4.3708510702 77.55 t max 1.943871 detik
18 11.25 21.38957485 10.1395748535 42.62 VD 0.670107
22 10.06 23.17104982 13.1110498218 239.415 c max 7.176 mg/L
55 4.45 44.83116958 40.3811695754 89.7 cl 0.007556 L/detik
78 3.35 71.01588944 67.6658894412
AUC total 661.69
AUC tak hingga 829.19
profil
15.51459 100
0.147012
mg/L.detik
mg/L.detik
7.176546 10

1
0 10 20 30 40 50 60 70 80 90

absorbsi
100 eliminasi
100

f(x)
10 = 18.9615934001 exp( - 2.4995258349 x ) 10
R² = 0.9007512589 f(x) = 14.9227314033 exp( - 0.0199885506 x )
R² = 0.9715395448
1
10 20 30 40 50 60 70 80 90
1
0 0.2 0.4 0.6 0.8 1 1.2
70 80 90

nasi

exp( - 0.0199885506 x )

0 60 70 80 90

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