Scribd
Upload
84 views

Naranjo Algorithm: Questionnaire

The Naranjo algorithm is a questionnaire designed to determine the likelihood that an adverse drug reaction is caused by a drug rather than other factors. It assigns a probability score of definite, probable, possible, or doubtful. The algorithm contains 10 questions that are each assigned points, with a total score corresponding to the probability determination. It has been used to verify conclusions about adverse drug reactions in peer reviews.

Uploaded by

ela amelia
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
84 views

Naranjo Algorithm: Questionnaire

The Naranjo algorithm is a questionnaire designed to determine the likelihood that an adverse drug reaction is caused by a drug rather than other factors. It assigns a probability score of definite, probable, possible, or doubtful. The algorithm contains 10 questions that are each assigned points, with a total score corresponding to the probability determination. It has been used to verify conclusions about adverse drug reactions in peer reviews.

Uploaded by

ela amelia
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 2

Naranjo algorithm

From Wikipedia, the free encyclopedia


Jump to navigationJump to search
The Naranjo algorithm, Naranjo Scale, or Naranjo Nomogram is a questionnaire designed by
Naranjo et al. for determining the likelihood of whether an ADR (adverse drug reaction) is
actually due to the drug rather than the result of other factors. Probability is assigned via a score
termed definite, probable, possible or doubtful. Values obtained from this algorithm are
sometimes used in peer reviews to verify the validity of author's conclusions regarding adverse
drug reactions. It is also called the Naranjo Scale or Naranjo Score.

Questionnaire[edit]
1. Are there previous conclusive reports on this reaction?
Yes (+1) No (0) Do not know or not done (0)

2. Did the adverse events appear after the suspected drug was given?
Yes (+2) No (-1) Do not know or not done (0)

3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was
given?
Yes (+1) No (0) Do not know or not done (0)

4. Did the adverse reaction appear when the drug was readministered?
Yes (+2) No (-1) Do not know or not done (0)

5. Are there alternative causes that could have caused the reaction?
Yes (-1) No (+2) Do not know or not done (0)

6. Did the reaction reappear when a placebo was given?


Yes (-1) No (+1) Do not know or not done (0)

7. Was the drug detected in any body fluid in toxic concentrations?


Yes (+1) No (0) Do not know or not done (0)

8. Was the reaction more severe when the dose was increased, or less severe when the dose
was decreased?
Yes (+1) No (0) Do not know or not done (0)

9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?
Yes (+1) No (0) Do not know or not done (0)

10. Was the adverse event confirmed by any objective evidence?


Yes (+1) No (0) Do not know or not done (0)

Scoring

 ≥ 9 = definite ADR
 5-8 = probable ADR
 1-4 = possible ADR
 0 = doubtful ADR
References[edit]
 Naranjo CA, Busto U, Sellers EM, et al. (1981). "A method for estimating the probability of
adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–
45. doi:10.1038/clpt.1981.154. PMID 7249508.

(https://en.wikipedia.org/wiki/Naranjo_algorithm)

You might also like