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Mouse (Mus Musculus)

The document summarizes genes and their functions across multiple species, including mouse, zebrafish, chick, and xenopus. It lists genes such as Apc, Brca1, and Bmpr1 in mouse that are involved in processes like tumor suppression, DNA repair, and bone morphogenesis. In zebrafish, genes such as SLC24A5 and PTPN11 are described as relating to pigmentation and development. In chick, genes like Fm, Tbx2, and BMPR1B are noted as playing roles in melanization, development, and chondrocyte differentiation. Finally, genes in xenopus such as tcf7l1-a, sry-box

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Jhestine Abayan
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41 views4 pages

Mouse (Mus Musculus)

The document summarizes genes and their functions across multiple species, including mouse, zebrafish, chick, and xenopus. It lists genes such as Apc, Brca1, and Bmpr1 in mouse that are involved in processes like tumor suppression, DNA repair, and bone morphogenesis. In zebrafish, genes such as SLC24A5 and PTPN11 are described as relating to pigmentation and development. In chick, genes like Fm, Tbx2, and BMPR1B are noted as playing roles in melanization, development, and chondrocyte differentiation. Finally, genes in xenopus such as tcf7l1-a, sry-box

Uploaded by

Jhestine Abayan
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Mouse (Mus musculus)

GENE FUNCTION
Apc (Adenomatous polyposis coli, encodes a multidomain protein that is an
alleletm2Rak) integral part of the beta-catenin and plays a
major role in tumor suppression by
antagonizing the WNT, Wnt pathway mediator;
transcription factor
Brca1 DNA repair; Tumor suppressor
Acd (adrenocortical dysplasia) Telomere capping. May affect pigmentation
through excess ACTH
Bmpr1 (Bone morphogenetic protein receptor, Bone morphogenetic protein receptor, type 1A
type 1)
Cited1 (Cbp/p300-interacting transactivator Cbp/p300-interacting transactivator with
with Glu/Asp-rich carboxy-terminal domain 1) Glu/Asp-rich carboxy-terminal domain 1
Dph1 (DPH1 homolog) diptheria toxin resistance protein required for
diphthamide biosynthesis-like 1 (S. cerevisiae);
ovarian cancer-associated gene
Edn3 (endothelin 3) Melanoblast/neuroblast growth and
differentiation factor associated with
Waardenburg-Shah Syndrome
Ednrb endothelin receptor B; Edn3 receptor
associated with Hirschsprung's disease type 2
Fgfr2 Fibroblast growth factor receptor 2 associated
with Crouzon syndrome, Apert syndrome,
Pfeiffer syndrome
Foxd3 forkhead box protein D3; transcription factor
associated with Vitiligo-associated multiple
autoimmune disease associated 2,
Susceptibility to autoimmune disease 1
Frem2 (Fras1 related extracellular matrix
Extracellular protein. Possibly epithelial-
protein 2 allele my-F11)
mesenchymal interactions at basement
membrane associated withFraser syndrome
Zebra fish (Danio rerio)
GENE FUNCTION
SLC24A5 encodes an intracellular membrane protein with
2 large hydrophilic loops and 2 sets of multiple
transmembrane-spanning segments, cation
exchanger involved in pigmentation, possibly
by participating in ion transport in
melanosomes. Sequence variation in this gene
has been associated with differences in skin
pigmentation
PTPN11 (protein-tyrosine phosphatase, non- Encodes SHP2, a cytoplasmic PTP that is
receptor type 11) essential for vertebrate development. Mutations
in PTPN11 are associated with Noonan and
LEOPARD syndrome.
DrPax1b gene development of the vertebral column,
pectoral fin and pharyngeal skeleton formation
Notch genes encode transmembrane receptors that interact
with numerous signal transduction pathways
and are essential for animal development
VEGFC gene In lymphangiogenesis, it acts on lymphatic
endothelial cells (LECs) primarily via its
receptor VEGFR-3 promoting survival, growth
and migration.
NITR genes Encode type I transmembrane glycoproteins
consisting of extracellular variable (V) and V-
like C2 (V/C2) domains, a transmembrane
region and a cytoplasmic tail. Encode
immunoreceptor tyrosine-based inhibition
motifs
Nacre genes(homolog of MITF) required for pigment cell differentiation

Chick (Gallus gallus)


GENE FUNCTION
Fm gene Plays role on the degree of melanization
(pigmentation)
Tbx-2 Encode transcription factors involved in the
regulation of developmental processes, may
have a potential role in tumorigenesis as an
immortalizing agent.
TBX3 Transcriptional repressor involved in
developmental processes. Probably plays a role
in limb pattern formation.
BMPR1B regulates chondrocyte differentiation positively
FGFR1 Tyrosine-protein kinase that acts as cell-surface
receptor for fibroblast growth factors.
Functions in the regulation of embryonic
development, cell proliferation, differentiation
and migration.
Mylk Phosphorylates a specific serine in the N-
terminus of a myosin light chain, which leads
to the formation of calmodulin/MLCK signal
transduction complexes which allow selective
transduction of calcium signals.
HOX genes (Homeobox genes) play an important role in the regulation of early
embryonic development
Ccbe1 key gene during early heart development
CALB1 stimulate a membrane Ca2+-ATPase and a
3',5'-cyclic nucleotide phosphodiesterase.
PTK2 plays a role in regulating cell migration,
adhesion, spreading, reorganization of the actin
cytoskeleton, formation and disassembly of
focal adhesions and cell protrusions, cell cycle
progression, cell proliferation and apoptosis
Xenopus
GENE FUNCTION
tcf7l1-a tcf3, tcf3a Plays a role in the Wnt signaling pathway.
Binds to DNA and acts as a repressor in the
absence of ctnnb1-A and possibly ctnnb1-B,
and as an activator in the presence of these
proteins.
SRY-box 17 alpha HMG-box transcription factor
lhx1 lim-1, lim1 Involved in the establishment of the body plan
via the Spemann organizer during gastrulation.
siamois Essential for Wnt/beta-catenin-mediated
formation of the Spemann organizer and for
induction of the organizer precursor, the
Nieuwkoop center.
Ib (XNC) genes Influences immunity and potentially other
physiological functions
tll2 xld In embryos, inhibits the development of
dorsoanterior structures and ventralizes activin-
induced dorsal mesoderm in animal caps.
FoxF1 development of visceral mesoderm and
the organogenesis of the gut
MIXL induce expression of the α-globin gene,
suggesting a functional conservation of the
homeodomain
hes4-a Binds DNA on N-box motifs: 5'-CACNAG-3'.
Particpates in the patterning of tissue
boundaries. It is also a transcriptional
repressor.
tyro3 ksy May be involved in cell adhesion processes,
particularly in the central nervous system.

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